scholarly journals Sustainable ppm level palladium-catalyzed aminations in nanoreactors under mild, aqueous conditions

2019 ◽  
Vol 10 (45) ◽  
pp. 10556-10561 ◽  
Author(s):  
Yitao Zhang ◽  
Balaram S. Takale ◽  
Fabrice Gallou ◽  
John Reilly ◽  
Bruce H. Lipshutz
Keyword(s):  
Mild Conditions ◽  
Palladium Catalyzed ◽  
Aqueous Conditions ◽  
Ppm Level

Greening-up aminations: a well-defined palladium pre-catalyst enables ppm-level Pd-catalyzed C–N cross couplings in water under very mild conditions. Comparisons using this protocol vs. traditional amination conditions for preparing key medicinal intermediates are demonstrated.

ChemInform Abstract: Mild Palladium-Catalyzed Oxidative Direct ortho-C-H Acylation of Anilides under Aqueous Conditions.

ChemInform ◽  
2013 ◽  
Vol 44 (32) ◽  
pp. no-no
Author(s):  
Fruzsina Szabo ◽  
Janos Daru ◽  
Daniel Simko ◽  
Tibor Zs. Nagy ◽  
Andras Stirling ◽  
...  
Keyword(s):  
Palladium Catalyzed ◽  
Aqueous Conditions

scholarly journals Palladium-catalyzed difluoromethylthiolation of heteroaryl bromides, iodides, triflates and aryl iodides

2016 ◽  
Vol 7 (6) ◽  
pp. 3757-3762 ◽  
Author(s):  
Jiang Wu ◽  
Yafei Liu ◽  
Changhui Lu ◽  
Qilong Shen
Keyword(s):  
Mild Conditions ◽  
Aryl Iodides ◽  
Palladium Catalyzed

A palladium-catalyzed difluoromethylthiolation of heteroaryl halides and triflates under mild conditions was described.

Efficient symmetrical bidentate dioxime ligand-accelerated homogeneous palladium-catalyzed Suzuki–Miyaura coupling reactions of aryl chlorides

2017 ◽  
Vol 41 (1) ◽  
pp. 372-376 ◽  
Author(s):  
Jinyi Song ◽  
Hongyan Zhao ◽  
Yang Liu ◽  
Huatao Han ◽  
Zhuofei Li ◽  
...  
Keyword(s):  
High Activity ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Bidentate Ligands ◽  
Aryl Chlorides ◽  
Arylboronic Acids ◽  
Mild Conditions ◽  
Cross Coupling Reactions ◽  
Palladium Catalyzed

A series of N,O-bidentate ligands were synthesized and studied as high activity ligands for palladium-catalyzed Suzuki–Miyaura cross-coupling reactions of aryl chlorides with arylboronic acids under mild conditions.

Palladium-Catalyzed Desulfurative Hiyama Coupling of Thioureas to Achieve Amides via Selective C–N Bond Cleavage

Synthesis ◽  
2021 ◽  
Author(s):  
Zhuo Zeng ◽  
Zhanyu He ◽  
Chu Yan ◽  
Mei Zhang ◽  
Majeed Irfan ◽  
...  
Keyword(s):  
Good Yield ◽  
Bond Cleavage ◽  
New Approach ◽  
Mild Conditions ◽  
Palladium Catalyzed

AbstractPalladium-catalyzed Hiyama coupling of active thioureas via selective C–N bond cleavage is reported. Notably, the new approach employed active thioureas as coupling partners in the presence of arylsilanes to give amides in good yield. Further, this strategy, which utilized CuF2 as a key oxidant and activator, afforded various amide products under mild conditions and an easy to handle procedure without extra base.

Palladium-Catalyzed One-Pot Stereospecific Synthesis of 2-Deoxy Aryl C-Glycosides from Glycals and Anilines in the Presence of tert-Butyl Nitrite

Synthesis ◽  
2019 ◽  
Vol 51 (22) ◽  
pp. 4215-4230 ◽  
Author(s):  
Adesh Kumar Singh ◽  
Rapelly Venkatesh ◽  
Jeyakumar Kandasamy
Keyword(s):  
Room Temperature ◽  
Stereospecific Synthesis ◽  
One Pot ◽  
Tert Butyl ◽  
Mild Conditions ◽  
One Pot Synthesis ◽  
Palladium Catalyzed ◽  
Aryl Glycosides

The palladium-catalyzed one-pot synthesis of 2,3-deoxy-3-keto aryl C-glycosides is achieved from glycals and anilines in the presence of tert-butyl nitrite and aqueous HBF4 under mild conditions. This one-pot method stereospecifically provides α- and β-aryl glycosides (≥19:1 by NMR) in good yields at room temperature. The configuration at the C-3 position in the glycal determines the anomeric selectivity (i.e., α or β) of the desired products.

Palladium-catalyzed allylic C–H oxidation under simple operation and mild conditions

2019 ◽  
Vol 17 (12) ◽  
pp. 3103-3107 ◽  
Author(s):  
Yunlong Guo ◽  
Zengming Shen
Keyword(s):  
Simple System ◽  
Allylic Alcohols ◽  
Bond Functionalization ◽  
Simple Operation ◽  
Mild Conditions ◽  
Palladium Catalyzed

We discovered an effective and simple system (Pd/BQ/air/r.t.) for making allylic alcohols through Pd-catalyzed allylic C–H bond functionalization.

Palladium-Catalyzed Cyanation under Mild Conditions: A Case Study to Discover Appropriate Substrates among Halides and Pseudohalides

Synlett ◽  
2020 ◽  
Vol 31 (16) ◽  
pp. 1629-1633
Author(s):  
K. Sunil ◽  
Merla Arjuna Rajendra ◽  
Ayyiliath Meleveetil Sajith ◽  
Muthipeedika Nibin Joy ◽  
Vasiliy A. Bakulev ◽  
...  
Keyword(s):  
Environmentally Benign ◽  
Potassium Hexacyanoferrate ◽  
Mild Conditions ◽  
Suitable Substrate ◽  
Wide Range ◽  
Palladium Catalyzed

A case study has been effectively carried out to identify a suitable substrate among halides and pseudohalides for the palladium-catalyzed cyanation reactions under mild conditions. Among the various substrates considered for evaluation, aryl pentafluorobenzenesulfonates and nonaflates were identified to be the best substrates when compared to corresponding halides and pseudohalides. The substoichiometric use of nontoxic, environmentally benign potassium hexacyanoferrate as a cyanide source and exceptionally milder conditions further highlights the significance of the protocol developed. A wide range of electronically biased and sterically challenging substrates provided the corresponding the nitriles in good to excellent yields.

ChemInform Abstract: Palladium-Catalyzed Carbonylative Synthesis of Aryl Formates under Mild Conditions.

ChemInform ◽  
2016 ◽  
Vol 47 (40) ◽  
Author(s):  
Li-Bing Jiang ◽  
Rui Li ◽  
Hao-Peng Li ◽  
Xinxin Qi ◽  
Xiao-Feng Wu
Keyword(s):  
Mild Conditions ◽  
Palladium Catalyzed
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