Lipid-anchor display on peptoid nanosheets via co-assembly for multivalent pathogen recognition

Soft Matter ◽  
2020 ◽  
Vol 16 (4) ◽  
pp. 907-913 ◽  
Author(s):  
Jae Hong Kim ◽  
Elissa M. Grzincic ◽  
Lisa Yun ◽  
Ryan K. Spencer ◽  
Mark A. Kline ◽  
...  
Keyword(s):  
Small Molecules ◽  
Two Dimensional ◽  
Pathogen Recognition ◽  
Lipid Anchor ◽  
Facile Route

A facile route to a diversity of functionalized two-dimensional bionanomaterials was developed based on the aqueous co-assembly of lipidated small molecules and nanosheet-forming peptoids.

Preparation of few‐layer two‐dimensional polymers by self‐assembly of bola‐amphiphilic small molecules

2019 ◽  
Vol 57 (16) ◽  
pp. 1748-1755 ◽  
Author(s):  
Na Zhang ◽  
Taisheng Wang ◽  
Xiaohai Bu ◽  
Qiong Wu ◽  
Zewu Zhang
Keyword(s):  
Small Molecules ◽  
Self Assembly ◽  
Two Dimensional

Fabrication of morphology controlled graphene oxide-dye composite films at the air–water interface

RSC Advances ◽  
2015 ◽  
Vol 5 (1) ◽  
pp. 552-557 ◽  
Author(s):  
Bahri Gür ◽  
Mehmet Şinoforoğlu ◽  
Kadem Meral
Keyword(s):  
Graphene Oxide ◽  
Composite Films ◽  
Water Interface ◽  
Two Dimensional ◽  
Langmuir Blodgett ◽  
Air Water Interface ◽  
Facile Route

This study presents a facile route for preparing two-dimensional (2D) graphene oxide-based composite films using the Langmuir–Blodgett (LB) method.

scholarly journals Development and Implementation of an HTS-Compatible Assay for the Discovery of Selective Small-Molecule Ligands for Pre-microRNAs

2017 ◽  
Vol 23 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Daniel A. Lorenz ◽  
Steve Vander Roest ◽  
Martha J. Larsen ◽  
Amanda L. Garner
Keyword(s):  
Small Molecules ◽  
Natural Product ◽  
Small Molecule ◽  
High Throughput ◽  
High Throughput Screening ◽  
Two Dimensional ◽  
Small Molecule Ligands ◽  
Gene Regulatory ◽  
Regulatory Rnas ◽  
Target Rna

microRNAs (miRNAs) are small gene regulatory RNAs, and their expression has been found to be dysregulated in a number of human diseases. To facilitate the discovery of small molecules capable of selectively modulating the activity of a specific miRNA, we have utilized new high-throughput screening technology targeting Dicer-mediated pre-miRNA maturation. Pilot screening of ~50,000 small molecules and ~33,000 natural product extract libraries against pre-miR-21 processing indicated the potential of our assay for this goal, yielding a campaign Z′ factor of 0.52 and an average plate signal-to-background (S/B) ratio of 13. Using two-dimensional screening against a second pre-miRNA, pre-let-7d, we evaluated the selectivity of confirmed hits. The results presented demonstrate how high-throughput screening can be used to identify selective small molecules for a target RNA.

Self-assembly of Janus disks induced by small molecules in two-dimensional systems

2017 ◽  
Vol 147 (1) ◽  
pp. 014904 ◽  
Author(s):  
M. Borówko ◽  
W. Rżysko ◽  
S. Sokołowski ◽  
T. Staszewski
Keyword(s):  
Small Molecules ◽  
Self Assembly ◽  
Two Dimensional

scholarly journals A facile route of two-dimensional metal oxide nanosheets fabrication by atomic layer deposition

2021 ◽  
Vol 1825 (1) ◽  
pp. 012042
Author(s):  
E Riyanto ◽  
E Martides ◽  
E Junianto ◽  
A Rajani ◽  
Kusnadi ◽  
...  
Keyword(s):  
Atomic Layer Deposition ◽  
Metal Oxide ◽  
Atomic Layer ◽  
Two Dimensional ◽  
Layer Deposition ◽  
Facile Route

scholarly journals The Influence of Disorder in the Synthesis, Characterization and Applications of a Modifiable Two-Dimensional Covalent Organic Framework

Materials ◽  
2020 ◽  
Vol 14 (1) ◽  
pp. 71
Author(s):  
Jordan Brophy ◽  
Kyle Summerfield ◽  
Jiashi Yin ◽  
Jon Kephart ◽  
Joshua T. Stecher ◽  
...  
Keyword(s):  
Monte Carlo Simulation ◽  
Small Molecules ◽  
Condensation Reaction ◽  
3D Structure ◽  
Polymerization Process ◽  
Two Dimensional ◽  
Porous Structures ◽  
Substitution Reactions ◽  
The Past ◽  
2D And 3D

Two-dimensional covalent organic frameworks (2D-COFs) have been of increasing interest in the past decade due to their porous structures that ideally can be highly ordered. One of the most common routes to these polymers relies on Schiff-base chemistry, i.e., the condensation reaction between a carbonyl and an amine. In this report, we elaborate on the condensation of 3,6-dibromobenzene-1,2,4,5-tetraamine with hexaketocyclohexane (HKH) and the subsequent carbonylation of the resulting COF, along with the possibility that the condensation reaction on HKH can result in a trans configuration resulting in the formation of a disordered 2D-COF. This strategy enables modification of COFs via bromine substitution reactions to place functional groups within the pores of the materials. Ion-sieving measurements using membranes from this COF, reaction of small molecules with unreacted keto groups along with modeling studies indicate disorder in the COF polymerization process. We also present a Monte Carlo simulation that demonstrates the influence of even small amounts of disorder upon both the 2D and 3D structure of the resulting COF.

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