Chemical stimulus-responsive supramolecular hydrogel formation and shrinkage of a hydrazone-containing short peptide derivative

Soft Matter ◽  
2020 ◽  
Vol 16 (4) ◽  
pp. 899-906 ◽  
Author(s):  
Takumi Sugiura ◽  
Takurou Kanada ◽  
Daisuke Mori ◽  
Hiroyuki Sakai ◽  
Aya Shibata ◽  
...  
Keyword(s):  
Exchange Reaction ◽  
Chemical Stimulus ◽  
Supramolecular Hydrogel ◽  
Short Peptide ◽  
Hydrazone Bond ◽  
Stimulus Responsive ◽  
Hydrogel Formation ◽  
Peptide Derivative

Herein, we describe a short peptide derivative containing a hydrazone bond showing transient hydrogel formation triggered by hydrazone–oxime exchange reaction.

A colon-targeted podophyllotoxin nanoprodrug: synthesis, characterization, and supramolecular hydrogel formation for the drug combination

2021 ◽  
Vol 9 (14) ◽  
pp. 3200-3209
Author(s):  
Wei Ha ◽  
Xiao-Bo Zhao ◽  
Wei-Hua Zhao ◽  
Jiang-Jiang Tang ◽  
Yan-Ping Shi
Keyword(s):  
Self Assembly ◽  
Drug Combination ◽  
Therapeutic Agents ◽  
Supramolecular Hydrogel ◽  
Assembly Strategy ◽  
Hydrogel Formation

An ingeniously designed podophyllotoxin nanoprodrug was synthesized and offered an effective platform for co-delivery of multiple therapeutic agents for drug combination via the hierarchical self-assembly strategy.

Stimulus-Responsive Short Peptide Nanogels for Controlled Intracellular Drug Release and for Overcoming Tumor Resistance

2017 ◽  
Vol 12 (7) ◽  
pp. 744-752 ◽  
Author(s):  
Linna Lyu ◽  
Fang Liu ◽  
Xiaoyong Wang ◽  
Ming Hu ◽  
Jing Mu ◽  
...  
Keyword(s):  
Drug Release ◽  
Tumor Resistance ◽  
Short Peptide ◽  
Stimulus Responsive

Supramolecular Hydrogel Formation in a Series of Self-Assembling Lipopeptides with Varying Lipid Chain Length

2017 ◽  
Vol 18 (7) ◽  
pp. 2013-2023 ◽  
Author(s):  
V. Castelletto ◽  
A. Kaur ◽  
R. M. Kowalczyk ◽  
I. W. Hamley ◽  
M. Reza ◽  
...  
Keyword(s):  
Chain Length ◽  
Supramolecular Hydrogel ◽  
Self Assembling ◽  
Hydrogel Formation ◽  
Lipid Chain

A chemically engineered, stable oligomer mimic of amyloid β42 containing an oxime switch for fibril formation

2018 ◽  
Vol 16 (35) ◽  
pp. 6537-6542 ◽  
Author(s):  
Masashi Yamamoto ◽  
Kiyomichi Shinoda ◽  
Jizhi Ni ◽  
Daisuke Sasaki ◽  
Motomu Kanai ◽  
...  
Keyword(s):  
Exchange Reaction ◽  
Fibril Formation ◽  
Chemical Stimulus ◽  
Aβ Oligomer

A stable Aβ oligomer mimic that is transformed into fibrils by a chemical stimulus, i.e., an oxime exchange reaction, is disclosed.

scholarly journals Development of an Amino Sugar-Based Supramolecular Hydrogelator with Reduction Responsiveness

2021 ◽  
Author(s):  
Sayuri L. Higashi ◽  
Masato Ikeda
Keyword(s):  
Molecular Weight ◽  
Molecular Design ◽  
Soft Materials ◽  
Amino Sugar ◽  
Low Molecular Weight ◽  
Stimuli Responsive ◽  
Supramolecular Hydrogel ◽  
Self Assembling ◽  
Hydrogel Formation

Stimuli-responsive supramolecular hydrogels are a newly emerging class of aqueous soft materials with a wide variety of bioapplications. Here we report a reduction-responsive supramolecular hydrogel constructed from a markedly simple low-molecular-weight hydrogelator, which is developed on the basis of modular molecular design containing a hydrophilic amino sugar and a reduction-responsive nitrophenyl group. The hydrogel formation ability differs significantly between glucosamine- and galactosamine-based self-assembling molecules, which are epimers at the C4 position, and only the glucosamine-based derivative can act as a hydrogelator.

Roles of both amines and acid in supramolecular hydrogel formation of tetracarboxyl acid-appended calix[4]arene gelator

RSC Advances ◽  
2015 ◽  
Vol 5 (26) ◽  
pp. 20066-20072 ◽  
Author(s):  
Heekyoung Choi ◽  
Ji Ha Lee ◽  
Jong Hwa Jung
Keyword(s):  
Tetracarboxylic Acid ◽  
Supramolecular Hydrogel ◽  
Arene Derivative ◽  
Hydrogel Formation

A tetracarboxylic acid-appended calix[4]arene derivative 1 which were insoluble in water could form a supramolecular hydrogel upon addition of both amines and HCl.

scholarly journals Glutathione-Triggered Formation of a Fmoc-Protected Short Peptide-Based Supramolecular Hydrogel

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e106968 ◽  
Author(s):  
Yang Shi ◽  
Jingyu Wang ◽  
Huaimin Wang ◽  
Yanhui Hu ◽  
Xuemei Chen ◽  
...  
Keyword(s):  
Supramolecular Hydrogel ◽  
Short Peptide

Pine nut antioxidant peptides ameliorate the memory impairment in a scopolamine-induced mice model via SIRT3-induced synaptic plasticity

2021 ◽  
Author(s):  
Hongyan Lu ◽  
Li Fang ◽  
Ji Wang ◽  
Fanrui Zhao ◽  
Chunlei Liu ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Memory Impairment ◽  
Mice Model ◽  
Antioxidant Peptides ◽  
Short Peptide ◽  
Pine Nut ◽  
Peptide Derivative

This study aimed to investigate the effects of a pine nut albumin hydrolysate (fraction < 3 kDa) and of its short peptide derivative, Trp-Tyr-Pro-Gly-Lys (WYPGK), on synaptic plasticity and memory...

Supramolecular Hydrogel Formation Based on Tannic Acid

2017 ◽  
Vol 50 (2) ◽  
pp. 666-676 ◽  
Author(s):  
Hailong Fan ◽  
Le Wang ◽  
Xunda Feng ◽  
Yazhong Bu ◽  
Decheng Wu ◽  
...  
Keyword(s):  
Tannic Acid ◽  
Supramolecular Hydrogel ◽  
Hydrogel Formation
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