Stimulus-Responsive Short Peptide Nanogels for Controlled Intracellular Drug Release and for Overcoming Tumor Resistance

Drug-delivery systems with a unique capability to respond to a given stimulus can improve therapeutic efficacy. However, development of such systems is currently heavily reliant on responsive polymeric materials and pursuing this singular strategy limits the potential for clinical translation. In this report, with a model system used for drug-release studies, we demonstrate a new strategy: how a temperature-responsive non-toxic, volatile liquid can be encapsulated and stored under ambient conditions and subsequently programmed for controlled drug release without relying on a smart polymer. When the stimulus temperature is reached, controlled encapsulation of different amounts of dye in the capsules is achieved and facilitates subsequent sustained release. With different ratios of the liquid (perfluorohexane): dye in the capsules, enhanced controlled release with real-time response is provided. Hence, our findings offer great potential for drug-delivery applications and provide new generic insights into the development of stimuli drug-release systems.

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Stimulus-responsive hydrogels reinforced by cellulose nanowhisker for controlled drug release

RSC Advances ◽

10.1039/c6ra14421g ◽

2016 ◽

Vol 6 (90) ◽

pp. 87422-87432 ◽

Cited By ~ 6

Author(s):

Y. Chen ◽

W. Y. Liu ◽

G. S. Zeng

Keyword(s):

Drug Release ◽

Controlled Drug Release ◽

Carboxymethyl Chitosan ◽

Stimuli Responsive ◽

Release System ◽

Cellulose Nanowhisker ◽

Hybrid Hydrogels ◽

System P ◽

Stimulus Responsive ◽

Responsive Hydrogels

Hybrid hydrogels (W–C gels), composed of PDMAEMA, cellulose nanowhisker (CNW) and carboxymethyl chitosan (CMCS), were prepared for developing a stimuli-responsive drug-release system.

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NIR light-responsive short peptide/2D NbSe2 nanosheets composite hydrogel with controlled-release capacity

Journal of Materials Chemistry B ◽

10.1039/c8tb03326a ◽

2019 ◽

Vol 7 (19) ◽

pp. 3134-3142 ◽

Cited By ~ 8

Author(s):

Can Wu ◽

Jing Liu ◽

Bin Liu ◽

Suyun He ◽

Guoru Dai ◽

...

Keyword(s):

Controlled Release ◽

Drug Release ◽

Composite Hydrogel ◽

Short Peptide ◽

Nir Light ◽

Release Capacity ◽

Peptide Hydrogels

The design of light-responsive peptide hydrogels with controllable drug release characteristics is still a challenge.

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Novel, Self-Distinguished, Dual Stimulus-Responsive Therapeutic Nanoplatform for Intracellular On-Demand Drug Release

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.0c00165 ◽

2020 ◽

Vol 17 (7) ◽

pp. 2435-2450

Author(s):

Heng Sun ◽

Zhongxiong Fan ◽

Sijin Xiang ◽

Wenbao Zuo ◽

Yifan Yang ◽

...

Keyword(s):

Drug Release ◽

On Demand ◽

Stimulus Responsive

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Synthesis Characterization of Platinum (IV) Complex Curcumin Backboned Polyprodrugs: In Vitro Drug Release Anticancer Activity

Polymers ◽

10.3390/polym13010067 ◽

2020 ◽

Vol 13 (1) ◽

pp. 67

Author(s):

Honglei Zhang ◽

Yanjuan Wu ◽

Xiao Xu ◽

Chen Chen ◽

Xiukun Xue ◽

...

Keyword(s):

Drug Release ◽

Combination Chemotherapy ◽

In Situ Polymerization ◽

Average Diameter ◽

Monomethyl Ether ◽

Resistant Cell ◽

Burst Release ◽

Tumor Resistance ◽

In Vitro Drug Release

The conventional mono-chemotherapy still suffers from unsatisfied potency for cancer therapy due to tumor heterogeneity and the occurrence of drug resistance. Combination chemotherapy based on the nanosized drug delivery systems (nDDSs) has been developed as a promising platform to circumvent the limitations of mono-chemotherapy. In this work, starting from cisplatin and curcumin (Cur), we prepared a dual drug backboned shattering polymeric nDDS for synergistic chemotherapy. By in situ polymerization of the Cur, platinum (IV) complex-based prodrug monomer (DHP), L-lysine diisocyanate (LDI), and then conjugation with a hydrophilic poly (ethylene glycol) monomethyl ether (mPEG) derivative, a backbone-type platinum (IV) and Cur linkage containing mPEG-poly(platinum-co-Cur)-mPEG (PCPt) copolymer was synthesized. Notably, the platinum (IV) (Pt (IV)) and Cur were incorporated into the hydrophobic segment of PCPt with the fixed drugs loading ratio and high drugs loading content. The batch-to-batch variability could be decreased. The resulting prodrug copolymer then self-assembled into nanoparticles (PCPt NPs) with an average diameter around 100 nm, to formulate a synergetic nDDS. Importantly, PCPt NPs could greatly improve the solubility and stability of Cur. In vitro drug release profiles have demonstrated that PCPt NPs were stable in PBS 7.4, rapid burst release was greatly decreased, and the Pt and Cur release could be largely enhanced under reductive conditions due to the complete dissociation of the hydrophobic main chain of PCPt. In vitro cell viability test indicated that PCPt NPs were efficient synergistic chemotherapy units. Moreover, PCPt NPs were synergistic for cisplatin-resistant cell lines A549/DDP cells, and they exhibited excellent reversal ability of tumor resistance to cisplatin. This work provides a promising strategy for the design and synthesis of nDDS for combination chemotherapy.

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Design and Application of Near-Infrared Nanomaterial-Liposome Hybrid Nanocarriers for Cancer Photothermal Therapy

Pharmaceutics ◽

10.3390/pharmaceutics13122070 ◽

2021 ◽

Vol 13 (12) ◽

pp. 2070

Author(s):

Pan Liang ◽

Linshen Mao ◽

Yanli Dong ◽

Zhenwen Zhao ◽

Qin Sun ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Photothermal Therapy ◽

Near Infrared ◽

Release Mechanism ◽

Enhanced Photoluminescence ◽

Drug Release Mechanism ◽

Stimulus Responsive ◽

Stable Particles ◽

Carbon Based Nanomaterials

Liposomes are attractive carriers for targeted and controlled drug delivery receiving increasing attention in cancer photothermal therapy. However, the field of creating near-infrared nanomaterial-liposome hybrid nanocarriers (NIRN-Lips) is relatively little understood. The hybrid nanocarriers combine the dual superiority of nanomaterials and liposomes, with more stable particles, enhanced photoluminescence, higher tumor permeability, better tumor-targeted drug delivery, stimulus-responsive drug release, and thus exhibiting better anti-tumor efficacy. Herein, this review covers the liposomes supported various types of near-infrared nanomaterials, including gold-based nanomaterials, carbon-based nanomaterials, and semiconductor quantum dots. Specifically, the NIRN-Lips are described in terms of their feature, synthesis, and drug-release mechanism. The design considerations of NIRN-Lips are highlighted. Further, we briefly introduced the photothermal conversion mechanism of NIRNs and the cell death mechanism induced by photothermal therapy. Subsequently, we provided a brief conclusion of NIRNs-Lips applied in cancer photothermal therapy. Finally, we discussed a synopsis of associated challenges and future perspectives for the applications of NIRN-Lips in cancer photothermal therapy.

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Electrically Stimulated Tunable Drug Delivery From Polypyrrole-Coated Polyvinylidene Fluoride

Frontiers in Chemistry ◽

10.3389/fchem.2021.599631 ◽

2021 ◽

Vol 9 ◽

Author(s):

Solaleh Miar ◽

Joo L. Ong ◽

Rena Bizios ◽

Teja Guda

Keyword(s):

Drug Delivery ◽

Growth Factors ◽

Growth Factor ◽

Drug Release ◽

Tissue Regeneration ◽

Polyvinylidene Fluoride ◽

Drug Loading ◽

Electrical Stimulus ◽

Musculoskeletal Tissue ◽

Stimulus Responsive

Electrical stimulus-responsive drug delivery from conducting polymers such as polypyrrole (PPy) has been limited by lack of versatile polymerization techniques and limitations in drug-loading strategies. In the present study, we report an in-situ chemical polymerization technique for incorporation of biotin, as the doping agent, to establish electrosensitive drug release from PPy-coated substrates. Aligned electrospun polyvinylidene fluoride (PVDF) fibers were used as a substrate for the PPy-coating and basic fibroblast growth factor and nerve growth factor were the model growth factors demonstrated for potential applications in musculoskeletal tissue regeneration. It was observed that 18-h of continuous polymerization produced an optimal coating of PPy on the surface of the PVDF electrospun fibers with significantly increased hydrophilicity and no substantial changes observed in fiber orientation or individual fiber thickness. This PPy-PVDF system was used as the platform for loading the aforementioned growth factors, using streptavidin as the drug-complex carrier. The release profile of incorporated biotinylated growth factors exhibited electrosensitive release behavior while the PPy-PVDF complex proved stable for a period of 14 days and suitable as a stimulus responsive drug delivery depot. Critically, the growth factors retained bioactivity after release. In conclusion, the present study established a systematic methodology to prepare PPy coated systems with electrosensitive drug release capabilities which can potentially be used to encourage targeted tissue regeneration and other biomedical applications.

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