An MRI-visible immunoadjuvant based on hollow Gd2O3 nanospheres for cancer immunotherapy

2020 ◽  
Vol 56 (59) ◽  
pp. 8186-8189
Author(s):  
Xia Li ◽  
Xiupeng Wang ◽  
Atsuo Ito
Keyword(s):  
Cancer Immunotherapy ◽  
Cellular Uptake ◽  
Tumor Antigen ◽  
Signal Intensity ◽  
Antitumor Immunity ◽  
Antigen Presenting Cells ◽  
Ph Dependent ◽  
Antigen Presenting

An MRI-visible immunoadjuvant based on hollow Gd2O3 nanospheres significantly promotes the cellular uptake of a tumor antigen by antigen presenting cells, exhibits pH-dependent alteration of the MR signal intensity and markedly enhances the antitumor immunity.

pH-Sensitive branched β-glucan-modified liposomes for activation of antigen presenting cells and induction of antitumor immunity

2021 ◽  
Author(s):  
Shin Yanagihara ◽  
Nozomi Kasho ◽  
Koichi Sasaki ◽  
Naoto Shironaka ◽  
Yukiya Kitayama ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Cellular Immunity ◽  
Antitumor Immunity ◽  
Antigen Presenting Cells ◽  
Ph Sensitive ◽  
Antigen Delivery ◽  
Antigen Presenting

Induction of cellular immunity is important for effective cancer immunotherapy. Although various antigen carriers for cancer immunotherapy have been developed to date, balancing efficient antigen delivery to antigen presenting cells...

scholarly journals Multi-Immune Agonist Nanoparticle Therapy Stimulates Type I Interferons to Activate Antigen-Presenting Cells and Induce Antigen-Specific Antitumor Immunity

2021 ◽  
Vol 18 (3) ◽  
pp. 1014-1025
Author(s):  
Elizabeth S. Levy ◽  
Ryan Chang ◽  
Colin R. Zamecnik ◽  
Miqdad O. Dhariwala ◽  
Lawrence Fong ◽  
...  
Keyword(s):  
Antitumor Immunity ◽  
Antigen Presenting Cells ◽  
Type I Interferons ◽  
Type I ◽  
Antigen Presenting

scholarly journals Selective tumor antigen vaccine delivery to human CD169+antigen-presenting cells using ganglioside-liposomes

2020 ◽  
Vol 117 (44) ◽  
pp. 27528-27539
Author(s):  
Alsya J. Affandi ◽  
Joanna Grabowska ◽  
Katarzyna Olesek ◽  
Miguel Lopez Venegas ◽  
Arnaud Barbaria ◽  
...  
Keyword(s):  
T Cells ◽  
Tumor Antigen ◽  
Tumor Antigens ◽  
Ex Vivo ◽  
Antigen Presenting Cells ◽  
Dependent Manner ◽  
Cross Presentation ◽  
Vaccine Carrier ◽  
Antigen Presenting

Priming of CD8+T cells by dendritic cells (DCs) is crucial for the generation of effective antitumor immune responses. Here, we describe a liposomal vaccine carrier that delivers tumor antigens to human CD169/Siglec-1+antigen-presenting cells using gangliosides as targeting ligands. Ganglioside-liposomes specifically bound to CD169 and were internalized by in vitro-generated monocyte-derived DCs (moDCs) and macrophages and by ex vivo-isolated splenic macrophages in a CD169-dependent manner. In blood, high-dimensional reduction analysis revealed that ganglioside-liposomes specifically targeted CD14+CD169+monocytes and Axl+CD169+DCs. Liposomal codelivery of tumor antigen and Toll-like receptor ligand to CD169+moDCs and Axl+CD169+DCs led to cytokine production and robust cross-presentation and activation of tumor antigen-specific CD8+T cells. Finally, Axl+CD169+DCs were present in cancer patients and efficiently captured ganglioside-liposomes. Our findings demonstrate a nanovaccine platform targeting CD169+DCs to drive antitumor T cell responses.

scholarly journals Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Alexei F. Kirkin ◽  
Karine N. Dzhandzhugazyan ◽  
Per Guldberg ◽  
Johnny Jon Fang ◽  
Rikke S. Andersen ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
T Helper Cells ◽  
Antigen Presenting Cells ◽  
T Helper ◽  
Helper Cells ◽  
Antigen Presenting
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