scholarly journals A novel, rationally designed lanthanoid chelating tag delivers large paramagnetic structural restraints for biomolecular NMR

2020 ◽  
Vol 56 (84) ◽  
pp. 12861-12864
Author(s):  
Daniel Joss ◽  
Florine Winter ◽  
Daniel Häussinger
Keyword(s):  
Long Range ◽  
Biomolecular Nmr ◽  
Structural Restraints

A novel, rationally designed lanthanoid chelating tag enables fast ligation to biomacromolecules and delivers long-range structural restraints by NMR.

Single-armed phenylsulfonated pyridine derivative of DOTA is rigid and stable paramagnetic tag in protein analysis

2016 ◽  
Vol 52 (77) ◽  
pp. 11535-11538 ◽  
Author(s):  
Feng Yang ◽  
Xiao Wang ◽  
Bin-Bin Pan ◽  
Xun-Cheng Su
Keyword(s):  
Long Range ◽  
Protein Analysis ◽  
Pyridine Derivative ◽  
Pyridine Derivatives ◽  
Site Specific ◽  
Protein Conjugates ◽  
Paramagnetic Tag ◽  
Structural Restraints ◽  
Respective Protein ◽  
Specific Labelling

Single-armed DOTA-like phenylsulfonated pyridine derivatives are rigid and stable paramagnetic tags for site-specific labelling of proteins. The respective protein conjugates yield valuable long-range structural restraints for proteins.

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