Design, synthesis and biological evaluation of dihydro-2-quinolone platinum(iv) hybrids as antitumor agents displaying mitochondria injury and DNA damage mechanism

2021 ◽  
Vol 50 (1) ◽  
pp. 362-375
Author(s):  
Zhifang Liu ◽  
Zuojie Li ◽  
Tao Du ◽  
Yan Chen ◽  
Qingpeng Wang ◽  
...  
Keyword(s):  
Dna Damage ◽  
Antitumor Agents ◽  
Cisplatin Resistance ◽  
Damage Mechanism ◽  
Biological Evaluation ◽  
Antitumor Activities ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Dihydro-2-quinolone platinum(iv) hybrids exhibit effective antitumor activities by causing serious mitochondria injury and DNA damage, and show great potential in reversing cisplatin resistance and improving antitumor efficacies.

Design, synthesis and biological evaluation of a novel series of glycosylated platinum(iv) complexes as antitumor agents

2016 ◽  
Vol 45 (25) ◽  
pp. 10366-10374 ◽  
Author(s):  
Qingpeng Wang ◽  
Zhonglv Huang ◽  
Jing Ma ◽  
Xiaolin Lu ◽  
Li Zhang ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Biological Evaluation ◽  
Antitumor Activities ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

A new series of glycosylated Pt(iv) complexes were designed, synthesized and evaluated for antitumor activities in vitro and in vivo.

Naproxen platinum(iv) hybrids inhibiting cycloxygenases and matrix metalloproteinases and causing DNA damage: synthesis and biological evaluation as antitumor agents in vitro and in vivo

2020 ◽  
Vol 49 (16) ◽  
pp. 5192-5204 ◽  
Author(s):  
Yan Chen ◽  
Qingpeng Wang ◽  
Zuojie Li ◽  
Zhifang Liu ◽  
Yanna Zhao ◽  
...  
Keyword(s):  
Dna Damage ◽  
Matrix Metalloproteinases ◽  
Antitumor Agents ◽  
Biological Evaluation ◽  
Antitumor Activities ◽  
Synthesis And Biological Evaluation

Naproxen platinum(iv) hybrids display effective antitumor activities by inhibiting cycloxygenases and matrix metalloproteinases and by causing DNA damage.

ChemInform Abstract: Antitumor Agents. Part 202. Novel 2′-Amino Chalcones: Design, Synthesis, and Biological Evaluation.

ChemInform ◽  
2010 ◽  
Vol 31 (29) ◽  
pp. no-no
Author(s):  
Yi Xia ◽  
Zheng-Yu Yang ◽  
Peng Xia ◽  
Kenneth F. Bastow ◽  
Yuka Nakanishi ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of thiourea and nicotinamide-containing sorafenib analogs as antitumor agents

MedChemComm ◽  
2015 ◽  
Vol 6 (5) ◽  
pp. 867-870 ◽  
Author(s):  
Xiangkai Kong ◽  
Zeyu Yao ◽  
Zuopeng He ◽  
Wenfang Xu ◽  
Jianwen Yao
Keyword(s):  
Antitumor Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Thiourea and nicotinamide-containing sorafenib analogs with better antiproliferative and anti-angiogenic activities than sorafenib were well designed and synthesized.

Design, synthesis, and biological evaluation of sorafenib derivatives containing indole (ketone) semicarbazide analogs as antitumor agents

2020 ◽  
Vol 57 (6) ◽  
pp. 2548-2560
Author(s):  
Wen Li ◽  
Ya‐Yun Qi ◽  
Yuan‐Yuan Wang ◽  
Yi‐Yuan Gan ◽  
Li‐Hui Shao ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis and biological evaluation of tryptamine salicylic acid derivatives as potential antitumor agents

MedChemComm ◽  
2019 ◽  
Vol 10 (4) ◽  
pp. 573-583 ◽  
Author(s):  
Runde Xiong ◽  
Dongxiu He ◽  
Xiangping Deng ◽  
Juan Liu ◽  
Xiaoyong Lei ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Salicylic Acid ◽  
Antitumor Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Combination Principle ◽  
Salicylic Acid Derivatives ◽  
Synthesis And Biological Evaluation ◽  
Tumor Agent ◽  
Potential Antitumor

According to the combination principle, target compounds were designed, and compound E20 might be a promising anti-tumor agent targeting gastric cancer.

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