Seeded droplet microfluidic system for small molecule crystallization

Lab on a Chip ◽  
2020 ◽  
Vol 20 (10) ◽  
pp. 1815-1826
Author(s):  
N. Garg ◽  
R. Tona ◽  
P. Martin ◽  
P. M. Martin-Soladana ◽  
G. Ward ◽  
...  
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Reverse Transcriptase ◽  
Size Distribution ◽  
Small Molecule ◽  
Transcriptase Inhibitor ◽  
Microfluidic System ◽  
Nucleoside Analog ◽  
Seeded Crystallization ◽  
Reverse Transcriptase Inhibitor

A microfluidic approach to seeded crystallization has been demonstrated using abacavir hemisulfate, a nucleoside analog reverse transcriptase inhibitor, in droplet reactors to control polymorphism and produce particles with a low particle size distribution.

scholarly journals Stampidine Is a Potent Inhibitor of Zidovudine- and Nucleoside Analog Reverse Transcriptase Inhibitor-Resistant Primary Clinical Human Immunodeficiency Virus Type 1 Isolates with Thymidine Analog Mutations

2002 ◽  
Vol 46 (11) ◽  
pp. 3613-3616 ◽  
Author(s):  
Fatih M. Uckun ◽  
Sharon Pendergrass ◽  
T. K. Venkatachalam ◽  
Sanjive Qazi ◽  
Douglas Richman
Keyword(s):  
Human Immunodeficiency Virus ◽  
Reverse Transcriptase ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Transcriptase Inhibitor ◽  
Nucleoside Analog ◽  
Immunodeficiency Virus ◽  
Reverse Transcriptase Inhibitor ◽  
Hiv 1

ABSTRACT We report the antiretroviral activity of stavudine-5′-(p-bromophenyl methoxyalaninyl phosphate) (stampidine [STAMP]), a novel aryl phosphate derivative of stavudine, against primary clinical human immunodeficiency virus type 1 (HIV-1) isolates. STAMP inhibited each one of nine clinical HIV-1 isolates of non-B envelope subtype and 20 genotypically and phenotypically nucleoside analog reverse transcriptase inhibitor-resistant HIV-1 isolates at subnanomolar to low-nanomolar concentrations.

Preparation of Nanostructured Lipid Drug Delivery Particles Using Microfluidic Mixing

2019 ◽  
Vol 7 (6) ◽  
pp. 484-495 ◽  
Author(s):  
Linda Hong ◽  
Yao-Da Dong ◽  
Ben J. Boyd
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
Liquid Crystalline ◽  
High Energy ◽  
Microfluidic System ◽  
Stimuli Responsive ◽  
Microfluidic Mixing ◽  
X Ray Scattering ◽  
The Impact

Background: Cubosomes are highly ordered self-assembled lipid particles analogous to liposomes, but with internal liquid crystalline structure. They are receiving interest as stimuli responsive delivery particles, but their preparation typically requires high energy approaches such as sonication which is not favourable in many applications. Objective: Here we investigated the impact of microfluidic preparation on particle size distribution and internal structure of cubosomes prepared from two different lipid systems, phytantriol and glyceryl monooleate (GMO). Methods: The impact of relative flow rates of the aqueous and organic streams, the total flow rate and temperature were investigated in a commercial microfluidic system. The particle size distribution and structure were measured using dynamic light scattering and small angle X-ray scattering respectively. Results: Phytantriol based particles were robust to different processing conditions, while cubosomes formed using GMO were more sensitive to composition both locally and globally, which reflects their preparation using other techniques. Conclusion: Thus, in summary microfluidics represents a reproducible and versatile method to prepare complex lipid particle dispersions such as cubosomes.

Crystal Structure of Abacavir Hemisulfate: A Nucleoside Analog Reverse Transcriptase Inhibitor

2009 ◽  
Vol 39 (12) ◽  
pp. 864-869 ◽  
Author(s):  
Jerry P. Jasinski ◽  
Ray J. Butcher ◽  
H. S. Yathirajan ◽  
L. Mallesha ◽  
K. N. Mohana ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Reverse Transcriptase ◽  
Transcriptase Inhibitor ◽  
Nucleoside Analog ◽  
Reverse Transcriptase Inhibitor
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