Polyethylene glycol-bonded triethylammonium l-prolinate: a new biodegradable amino-acid-based ionic liquid for the one-pot synthesis of bis(pyrazolyl)methanes as DNA binding agents

2020 ◽  
Vol 44 (39) ◽  
pp. 16995-17012
Author(s):  
Reza Kordnezhadian ◽  
Mohsen Shekouhy ◽  
Somaye Karimian ◽  
Zohreh Tavaf ◽  
Saeed Malek-Hosseini ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Polyethylene Glycol ◽  
Amino Acid ◽  
Dna Binding ◽  
One Pot ◽  
One Pot Synthesis ◽  
Binding Agents ◽  
Dna Binding Agents ◽  
The One

[PEG-TEA]LP, as a new biodegradable ionic liquid catalyst, was successfully synthesized, characterized, and applied to the one-pot pseudo-five-component synthesis of bis(pyrazolyl)methanes.

A one-pot synthesis of benzimidazoles via aerobic oxidative condensation of benzyl alcohols with o-phenylenediamines catalyzed by [MIMPs]+Cl-/NaNO2/TEMPO

2020 ◽  
Vol 44 (9-10) ◽  
pp. 557-565
Author(s):  
Zhenzhen Geng ◽  
Hong-yu Zhang ◽  
Guohui Yin ◽  
Yuecheng Zhang ◽  
Jiquan Zhao
Keyword(s):  
Ionic Liquid ◽  
Catalytic System ◽  
Sodium Nitrite ◽  
High Efficiency ◽  
Oxidative Condensation ◽  
Imidazolium Chloride ◽  
One Pot ◽  
Benzyl Alcohols ◽  
One Pot Synthesis ◽  
The One

The ionic liquid 1-methyl-3-(3-sulfopropyl)imidazolium chloride ([MIMPs]+Cl-) in combination with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and sodium nitrite (NaNO2) as a catalytic system demonstrates high efficiency in the one-pot two-step aerobic oxidative condensation of benzyl alcohols with 1,2-phenylenediamines to give benzimidazoles. Various benzimidazoles are obtained in good to excellent yields by this strategy.

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