NIR-controlled HSP90 inhibitor release from hollow mesoporous nanocarbon for synergistic tumor photothermal therapy guided by photoacoustic imaging

Nanoscale ◽  
2020 ◽  
Vol 12 (27) ◽  
pp. 14775-14787
Author(s):  
Jiaxin Sun ◽  
Yongjing Li ◽  
Yilong Teng ◽  
Sheng Wang ◽  
Jia Guo ◽  
...  
Keyword(s):  
Therapeutic Effect ◽  
Photothermal Therapy ◽  
Mesoporous Carbon ◽  
Photoacoustic Imaging ◽  
Drug Carriers ◽  
Hsp90 Inhibitor ◽  
Carbon Nanospheres ◽  
Mild Temperature

Hollow mesoporous carbon nanospheres were used as drug carriers for mild-temperature photothermal therapy, which showed a significant NIR-enhanced synergistic tumor therapeutic effect guided by photoacoustic imaging.

Hollow mesoporous carbon nanospheres for imaging-guided light-activated synergistic thermo-chemotherapy

Nanoscale ◽  
2019 ◽  
Vol 11 (35) ◽  
pp. 16351-16361 ◽  
Author(s):  
Yuwei Qiu ◽  
Dandan Ding ◽  
Wenjing Sun ◽  
Yushuo Feng ◽  
Doudou Huang ◽  
...  
Keyword(s):  
Mesoporous Carbon ◽  
Photoacoustic Imaging ◽  
Drug Loading ◽  
Carbon Nanospheres ◽  
High Drug ◽  
Photothermal Conversion ◽  
High Drug Loading

Hollow mesoporous carbon nanospheres were able to achieve high drug loading, excellent photoacoustic imaging ability and photothermal conversion efficacy, enabling imaging-guided light-activated synergistic therapy.

NIR-active Nanoterminator with Mature Dendritic Cell Acitivities for Immuno-Priming Mild Photothermal Cancer Therapy

2020 ◽  
Author(s):  
zhihong sun ◽  
Guanjun Deng ◽  
Xinghua Peng ◽  
Xiuli Xu ◽  
Lanlan Liu ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Photothermal Therapy ◽  
Whole Body ◽  
Mature Dendritic Cell ◽  
Immune Microenvironment ◽  
Highly Efficient ◽  
Tumor Immune Microenvironment ◽  
Shock Proteins ◽  
Mild Temperature ◽  
Broad Interest

Recently, photothermal-immuno synergistic therapy under mild temperature (~ 45 °C) has got broad interest in cancer treatment. Inhibition the intratumorally HSPs production is the key to accomplish highly efficient and mild photothermal therapy. In this work, we developed biomimetic nanoterminators with mature DCs functions by coating the mature dendritic cell membrane on photothermal nanoagents. As-prepared nanoterminators could automatically locate on T cell in the complex tumor-immune microenvironment and promote the T cells proliferation, activation and cytokine secretion, which could not only inhibit the expression of heat shock proteins to cooperate on highly efficient mild photothermal therapy (~42°C), but also promote tumor apoptosis during the treatment. More importantly, this nanoterminator could serve as vaccine to trigger anti-tumor immune response of the whole body, which would be promising to long-life tumor inhibition and termination.

Confined Selenium in N-Doped Mesoporous Carbon Nanospheres for Sodium-Ion Batteries

2021 ◽  
Vol 13 (14) ◽  
pp. 16558-16566
Author(s):  
Wei Sun ◽  
Kang Guo ◽  
JinChen Fan ◽  
Yulin Min ◽  
Qunjie Xu
Keyword(s):  
Mesoporous Carbon ◽  
Sodium Ion ◽  
Sodium Ion Batteries ◽  
Carbon Nanospheres

Electrochemical Sensor for the Rutin Detection Based On N-Doped Mesoporous Carbon Nanospheres and Graphene

2021 ◽  
Author(s):  
Qingfang Zhen ◽  
Huiyuan Ma ◽  
Zhongxin Jin ◽  
Di Zhu ◽  
Xiao Liu ◽  
...  
Keyword(s):  
Electrochemical Sensor ◽  
Mesoporous Carbon ◽  
Carbon Nanospheres ◽  
Ordered Mesoporous

In this work, a novel composite based on N-doped mesoporous carbon nanospheres and graphene (N-MCS@graphene) is successfully designed and constructed for the rutin (RT) detection. The ordered mesoporous architecture offers...

Pyrazino[2,3-g]quinoxaline-Based Nanoparticles as Near-Infrared Phototheranostic Agents for Efficient Photoacoustic-Imaging-Guided Photothermal Therapy

2021 ◽  
Vol 4 (2) ◽  
pp. 2019-2029
Author(s):  
Li-Peng Zhang ◽  
Lin Kang ◽  
Xianqiang Li ◽  
Shiyang Liu ◽  
Tianlong Liu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging
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