scholarly journals Shortwave-infrared (SWIR) fluorescence molecular imaging using indocyanine green–antibody conjugates for the optical diagnostics of cancerous tumours

RSC Advances ◽  
2020 ◽  
Vol 10 (47) ◽  
pp. 28171-28179 ◽  
Author(s):  
Setsuko Tsuboi ◽  
Takashi Jin
Keyword(s):  
Molecular Imaging ◽  
Indocyanine Green ◽  
Optical Detection ◽  
Optical Diagnostics ◽  
Skin Tumours ◽  
Highly Sensitive ◽  
Antibody Conjugates ◽  
Shortwave Infrared ◽  
Fluorescence Molecular Imaging

We present indocyanine green (ICG)-based shortwave-infrared (SWIR) fluorescence molecular imaging for the highly-sensitive optical detection of breast and skin tumours in mice.

scholarly journals Affibody-Indocyanine Green Based Contrast Agent for Photoacoustic and Fluorescence Molecular Imaging of B7–H3 Expression in Breast Cancer

2019 ◽  
Vol 30 (6) ◽  
pp. 1677-1689 ◽  
Author(s):  
Rakesh Bam ◽  
Makenna Laffey ◽  
Katharine Nottberg ◽  
Patrick S. Lown ◽  
Benjamin J. Hackel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Imaging ◽  
Indocyanine Green ◽  
Contrast Agent ◽  
Fluorescence Molecular Imaging

Fluorescence Molecular Imaging of Small Animal Tumor Models

2004 ◽  
Vol 4 (4) ◽  
pp. 419-430 ◽  
Author(s):  
E. Graves ◽  
R. Weissleder ◽  
V. Ntziachristos
Keyword(s):  
Molecular Imaging ◽  
Small Animal ◽  
Tumor Models ◽  
Animal Tumor ◽  
Fluorescence Molecular Imaging

scholarly journals Paired-Agent Fluorescence Molecular Imaging of Sentinel Lymph Nodes Using Indocyanine Green as a Control Agent for Antibody-Based Targeted Agents

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Chengyue Li ◽  
Xiaochun Xu ◽  
Nathan McMahon ◽  
Omar Alhaj Ibrahim ◽  
Husain A. Sattar ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Lymph Nodes ◽  
Indocyanine Green ◽  
Metastatic Breast ◽  
Control Agent ◽  
Sentinel Lymph Nodes ◽  
Imaging Agent ◽  
Binding Potential ◽  
Cancer Spread ◽  
Kinetics Of

Purpose. Paired-agent molecular imaging methods, which employ coadministration of an untargeted, “control” imaging agent with a targeted agent to correct for nonspecific uptake, have been demonstrated to detect 200 cancer cells in a mouse model of metastatic breast cancer. This study demonstrates that indocyanine green (ICG), which is approved for human use, is an ideal control agent for future paired-agent studies to facilitate eventual clinical translation. Methods. The kinetics of ICG were compared with a known ideal control imaging agent, IRDye-700DX-labeled antibody in both healthy and metastatic rat popliteal lymph nodes after coadministration, intradermally in the footpad. Results. The kinetics of ICG and antibody-based imaging agent in tumor-free rat lymph nodes demonstrated a strong correlation with each other (r = 0.98, p<0.001) with a measured binding potential of −0.102 ± 0.03 at 20 min postagent injection, while the kinetics of ICG and targeted imaging agent shows significant separation in the metastatic lymph nodes. Conclusion. This study indicated a potential for microscopic sensitivity to cancer spread in sentinel lymph nodes using ICG as a control agent for antibody-based molecular imaging assays.

P-161 EGFR-targeted fluorescence molecular imaging for postoperative lymph node assessment in patients with oral cancer

Oral Oncology ◽  
2021 ◽  
Vol 118 ◽  
pp. 17
Author(s):  
J. Vonk ◽  
J.G. deWit ◽  
F.J. Voskuil ◽  
Y.H. Tang ◽  
W.T.R. Hooghiemstra ◽  
...  
Keyword(s):  
Lymph Node ◽  
Molecular Imaging ◽  
Oral Cancer ◽  
Lymph Node Assessment ◽  
Fluorescence Molecular Imaging

Electrochemical biosensor for detection of pathogenic bacteria based on dual signal amplification of Cu3(PO4)2-mediated click chemistry and DNAzyme

The Analyst ◽  
2021 ◽  
Author(s):  
Hongguo Wei ◽  
Jiayu Wan ◽  
Shengjun Bu ◽  
Wenguang Zhang ◽  
Ma Li ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Magnetic Separation ◽  
Concanavalin A ◽  
Signal Amplification ◽  
Pathogenic Bacteria ◽  
Electrochemical Biosensor ◽  
Inorganic Hybrid ◽  
Highly Sensitive ◽  
Antibody Conjugates ◽  
Dual Signal Amplification

A novel electrochemical biosensor for detecting pathogenic bacteria was designed based on specific magnetic separation and highly sensitive click chemistry. Instead of enzyme-antibody conjugates, organic-inorganic hybrid nanoflowers (Concanavalin A (Con...

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