scholarly journals Illuminating necrosis: From mechanistic exploration to preclinical application using fluorescence molecular imaging with indocyanine green

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Cheng Fang ◽  
Kun Wang ◽  
Chaoting Zeng ◽  
Chongwei Chi ◽  
Wenting Shang ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Indocyanine Green ◽  
Fluorescence Molecular Imaging

scholarly journals Shortwave-infrared (SWIR) fluorescence molecular imaging using indocyanine green–antibody conjugates for the optical diagnostics of cancerous tumours

RSC Advances ◽  
2020 ◽  
Vol 10 (47) ◽  
pp. 28171-28179 ◽  
Author(s):  
Setsuko Tsuboi ◽  
Takashi Jin
Keyword(s):  
Molecular Imaging ◽  
Indocyanine Green ◽  
Optical Detection ◽  
Optical Diagnostics ◽  
Skin Tumours ◽  
Highly Sensitive ◽  
Antibody Conjugates ◽  
Shortwave Infrared ◽  
Fluorescence Molecular Imaging

We present indocyanine green (ICG)-based shortwave-infrared (SWIR) fluorescence molecular imaging for the highly-sensitive optical detection of breast and skin tumours in mice.

scholarly journals Affibody-Indocyanine Green Based Contrast Agent for Photoacoustic and Fluorescence Molecular Imaging of B7–H3 Expression in Breast Cancer

2019 ◽  
Vol 30 (6) ◽  
pp. 1677-1689 ◽  
Author(s):  
Rakesh Bam ◽  
Makenna Laffey ◽  
Katharine Nottberg ◽  
Patrick S. Lown ◽  
Benjamin J. Hackel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Imaging ◽  
Indocyanine Green ◽  
Contrast Agent ◽  
Fluorescence Molecular Imaging

scholarly journals Intraoperative Resection Guidance with Photoacoustic and Fluorescence Molecular Imaging Using an Anti–B7-H3 Antibody-Indocyanine Green Dual Contrast Agent

2018 ◽  
Vol 24 (15) ◽  
pp. 3572-3582 ◽  
Author(s):  
Katheryne E. Wilson ◽  
Sunitha V. Bachawal ◽  
Jürgen K. Willmann
Keyword(s):  
Molecular Imaging ◽  
Indocyanine Green ◽  
Contrast Agent ◽  
Fluorescence Molecular Imaging

Fluorescence Molecular Imaging of Small Animal Tumor Models

2004 ◽  
Vol 4 (4) ◽  
pp. 419-430 ◽  
Author(s):  
E. Graves ◽  
R. Weissleder ◽  
V. Ntziachristos
Keyword(s):  
Molecular Imaging ◽  
Small Animal ◽  
Tumor Models ◽  
Animal Tumor ◽  
Fluorescence Molecular Imaging

scholarly journals Paired-Agent Fluorescence Molecular Imaging of Sentinel Lymph Nodes Using Indocyanine Green as a Control Agent for Antibody-Based Targeted Agents

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Chengyue Li ◽  
Xiaochun Xu ◽  
Nathan McMahon ◽  
Omar Alhaj Ibrahim ◽  
Husain A. Sattar ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Lymph Nodes ◽  
Indocyanine Green ◽  
Metastatic Breast ◽  
Control Agent ◽  
Sentinel Lymph Nodes ◽  
Imaging Agent ◽  
Binding Potential ◽  
Cancer Spread ◽  
Kinetics Of

Purpose. Paired-agent molecular imaging methods, which employ coadministration of an untargeted, “control” imaging agent with a targeted agent to correct for nonspecific uptake, have been demonstrated to detect 200 cancer cells in a mouse model of metastatic breast cancer. This study demonstrates that indocyanine green (ICG), which is approved for human use, is an ideal control agent for future paired-agent studies to facilitate eventual clinical translation. Methods. The kinetics of ICG were compared with a known ideal control imaging agent, IRDye-700DX-labeled antibody in both healthy and metastatic rat popliteal lymph nodes after coadministration, intradermally in the footpad. Results. The kinetics of ICG and antibody-based imaging agent in tumor-free rat lymph nodes demonstrated a strong correlation with each other (r = 0.98, p<0.001) with a measured binding potential of −0.102 ± 0.03 at 20 min postagent injection, while the kinetics of ICG and targeted imaging agent shows significant separation in the metastatic lymph nodes. Conclusion. This study indicated a potential for microscopic sensitivity to cancer spread in sentinel lymph nodes using ICG as a control agent for antibody-based molecular imaging assays.

P-161 EGFR-targeted fluorescence molecular imaging for postoperative lymph node assessment in patients with oral cancer

Oral Oncology ◽  
2021 ◽  
Vol 118 ◽  
pp. 17
Author(s):  
J. Vonk ◽  
J.G. deWit ◽  
F.J. Voskuil ◽  
Y.H. Tang ◽  
W.T.R. Hooghiemstra ◽  
...  
Keyword(s):  
Lymph Node ◽  
Molecular Imaging ◽  
Oral Cancer ◽  
Lymph Node Assessment ◽  
Fluorescence Molecular Imaging

scholarly journals Intraoperative Imaging-Guided Cancer Surgery: From Current Fluorescence Molecular Imaging Methods to Future Multi-Modality Imaging Technology

Theranostics ◽  
2014 ◽  
Vol 4 (11) ◽  
pp. 1072-1084 ◽  
Author(s):  
Chongwei Chi ◽  
Yang Du ◽  
Jinzuo Ye ◽  
Deqiang Kou ◽  
Jingdan Qiu ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Intraoperative Imaging ◽  
Cancer Surgery ◽  
Imaging Technology ◽  
Imaging Methods ◽  
Fluorescence Molecular Imaging

Optical Coherence Tomography, Near-Infrared Spectroscopy, and Near-Infrared Fluorescence Molecular Imaging

2016 ◽  
pp. 91-106
Author(s):  
Ismail Dogu Kilic ◽  
Roberta Serdoz ◽  
Enrico Fabris ◽  
Farouc Amin Jaffer ◽  
Carlo Di Mario
Keyword(s):  
Optical Coherence Tomography ◽  
Infrared Spectroscopy ◽  
Molecular Imaging ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Optical Coherence ◽  
Near Infrared Fluorescence ◽  
Fluorescence Molecular Imaging

scholarly journals A parallel adaptive finite element simplified spherical harmonics approximation solver for frequency domain fluorescence molecular imaging

2010 ◽  
Vol 55 (16) ◽  
pp. 4625-4645 ◽  
Author(s):  
Yujie Lu ◽  
Banghe Zhu ◽  
Haiou Shen ◽  
John C Rasmussen ◽  
Ge Wang ◽  
...  
Keyword(s):  
Finite Element ◽  
Molecular Imaging ◽  
Frequency Domain ◽  
Spherical Harmonics ◽  
Adaptive Finite Element ◽  
Fluorescence Molecular Imaging

Visualization of pulmonary inflammation using noninvasive fluorescence molecular imaging

2008 ◽  
Vol 104 (3) ◽  
pp. 795-802 ◽  
Author(s):  
Jodi Haller ◽  
Damon Hyde ◽  
Nikolaos Deliolanis ◽  
Ruben de Kleine ◽  
Mark Niedre ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Quantitative Imaging ◽  
Pulmonary Inflammation ◽  
Small Animal ◽  
Mouse Lung ◽  
Chronic Obstructive ◽  
Therapy Assessment ◽  
Fluorescence Molecular Imaging

The ability to visualize molecular processes and cellular regulators of complex pulmonary diseases such as asthma, chronic obstructive pulmonary disease (COPD), or adult respiratory distress syndrome (ARDS), would aid in the diagnosis, differentiation, therapy assessment and in small animal-based drug-discovery processes. Herein we report the application of normalized transillumination and fluorescence molecular tomography (FMT) for the noninvasive quantitative imaging of the mouse lung in vivo. We demonstrate the ability to visualize and quantitate pulmonary response in a murine model of LPS-induced airway inflammation. Twenty-four hours prior to imaging, BALB/c female mice were injected via tail vein with 2 nmol of a cathepsin-sensitive activatable fluorescent probe (excitation: 750 nm; emission: 780 nm) and 2 nmol of accompanying intravascular agent (excitation: 674 nm; emission: 694 nm). Six hours later, the mice were anesthetized with isoflurane and administered intranasal LPS in sterile 0.9% saline in 25 μl aliquots (one per nostril). Fluorescence molecular imaging revealed the in vivo profile of cysteine protease activation and vascular distribution within the lung typifying the inflammatory response to LPS insult. Results were correlated with standard in vitro laboratory tests (Western blot, bronchoalveolar lavage or BAL analysis, immunohistochemistry) and revealed good correlation with the underlying activity. We demonstrated the capacity of fluorescence tomography to noninvasively and longitudinally characterize physiological, cellular, and subcellular processes associated with inflammatory disease burden in the lung. The data presented herein serve to further evince fluorescence molecular imaging as a technology highly appropriate for the biomedical laboratory.

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