Identification of β-strand mediated protein–protein interaction inhibitors using ligand-directed fragment ligation
Dynamic ligation screening is used to identify acylhydrazone-linked peptide-fragment hybrids which bind to the SHANK1 PDZ domain with comparable affinity to the native GKAP peptide as shown by biophysical and structural analyses.
2008 ◽
Vol 1780
(4)
◽
pp. 696-708
◽
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