Engineering nanoparticles to tackle tumor barriers

2020 ◽  
Vol 8 (31) ◽  
pp. 6686-6696 ◽  
Author(s):  
Jia-Xian Li ◽  
Qiu-Yue Huang ◽  
Jing-Yang Zhang ◽  
Jin-Zhi Du
Keyword(s):  
Vascular Transport ◽  
Interstitial Transport

Engineering strategies of nanoparticles were elaborated to overcome delivery barriers from the perspectives of trans-vascular transport and interstitial transport.

Computational Model of Interstitial Transport in the Rat Brain Using Diffusion Tensor Imaging

2007 ◽  
Author(s):  
Jung Hwan Kim ◽  
Thomas H. Mareci ◽  
Malisa Sarntinoranont
Keyword(s):  
Diffusion Tensor ◽  
Therapeutic Potential ◽  
Treatment Optimization ◽  
Convection Enhanced Delivery ◽  
Tissue Properties ◽  
Large Molecules ◽  
Macromolecular Drugs ◽  
Interstitial Transport ◽  
Blood Spinal Cord Barrier ◽  
The Brain

In spite of the high therapeutic potential of macromolecular drugs, it has proven difficult to apply them to recovery after injury and treatment of cancer, Parkinson’s disease, and other neurodegenerative diseases. One barrier to systemic administration is low capillary permeability, i.e., the blood-brain and blood-spinal cord barrier. To overcome this barrier, convection-enhanced delivery (CED) infuses agents directly into tissue to supplement diffusion and increase the distribution of large molecules in the brain [1,2]. Predictive models of distribution during CED would be useful in treatment optimization and planning. To account for large infusion volumes, such models should incorporate tissue boundaries and anisotropic tissue properties.

Computational Model of Interstitial Transport in the Spinal Cord using Diffusion Tensor Imaging

2006 ◽  
Vol 34 (8) ◽  
pp. 1304-1321 ◽  
Author(s):  
Malisa Sarntinoranont ◽  
Xiaoming Chen ◽  
Jianbing Zhao ◽  
Thomas H. Mareci
Keyword(s):  
Spinal Cord ◽  
Diffusion Tensor Imaging ◽  
Computational Model ◽  
Diffusion Tensor ◽  
Interstitial Transport

Vascular transport capacity of hindlimb muscles of exercise-trained rats

1987 ◽  
Vol 62 (2) ◽  
pp. 438-443 ◽  
Author(s):  
M. H. Laughlin ◽  
J. Ripperger
Keyword(s):  
Ethylenediaminetetraacetic Acid ◽  
Exchange Capacity ◽  
Transport Capacity ◽  
Diffusion Capacity ◽  
Capillary Filtration ◽  
Vascular Transport ◽  
Flow Capacity ◽  
Vascular Flow ◽  
Regional Flow ◽  
Capillary Exchange

The purpose of this study was to determine whether chronic exercise training is associated with increased vascular flow capacity and capillary exchange capacity in skeletal muscles. One group of male Sprague-Dawley rats was cage confined for a period of 13'17 wk (sedentary control, C) and a second was trained for 1 h/day at a speed of 30 m/min up a 5 degrees incline for 13–17 wk (exercise trained, ET). Studies were conducted with maximally dilated (papaverine) isolated hindquarters of 13 C rats and 10 ET rats perfused with Tyrode's solution containing 5% albumin. Vascular flow capacity was estimated by measuring total and regional flows at three to five different perfusion pressures. Capillary exchange capacity was estimated by measuring maximal capillary filtration coefficients and capillary diffusion capacity for 51Cr-ethylenediaminetetraacetic acid (51Cr-EDTA). The efficacy of the training was shown by significant increases in succinate dehydrogenase activities of the vastus intermedius muscle. Total hindquarter flow capacity was 50% higher in the ET rats. Regional flow data indicated that the higher total flow was due to increased muscle flow (85%), with the high-oxidative muscle tissue having the greatest increases (e.g., 200% increase in red gastrocnemius muscle). The maximal capillary diffusion capacity values for the ET rats were 70% greater than control values. However, the capillary filtration capacity values of the C and ET rats were not different. We conclude that the vascular transport capacity of the high-oxidative areas of extensor muscles is increased by endurance training.

Vascular Transport in Plants

2006 ◽  
Vol 35 (2) ◽  
pp. 688-688 ◽  
Author(s):  
Nicholas W. Lepp
Keyword(s):  
Vascular Transport

Relaxation Of Non-Equilibrium Hydrogen Distributions In a-Si:H

1998 ◽  
Vol 513 ◽  
Author(s):  
Guy J. Adriaenssens ◽  
Qing Zhiang
Keyword(s):  
Level Energy ◽  
Equivalent Formulation ◽  
Relaxation Kinetics ◽  
Energy Diagram ◽  
Original Proposal ◽  
Interstitial Transport ◽  
Non Equilibrium

ABSTRACTIt is shown that a reduction of the three-level energy diagram proposed by Van de Walle (Phys. Rev. B 53, 11292, 1996) to describe the relaxation of non-equilibrium hydrogen distributions, to just the interstitial transport level and a distribution of traps, allows an essentially equivalent formulation of the hydrogen relaxation kinetics. The modified formulation offers the possibility of accounting for dispersive diffusion while preserving the essential multiple retrapping aspect of the original proposal.

Uptake and vascular transport of ingested aflatoxin

1985 ◽  
Vol 29 (2-3) ◽  
pp. 169-176 ◽  
Author(s):  
R. Wilson ◽  
R. Ziprin ◽  
S. Ragsdale ◽  
D. Busbee
Keyword(s):  
Vascular Transport
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