A highly sensitive electrochemical microRNA-21 biosensor based on intercalating methylene blue signal amplification and a highly dispersed gold nanoparticles/graphene/polypyrrole composite

An ultrasensitive electrochemical biosensor based on a gold nanoparticles/graphene/polypyrrole composite modified electrode and a signal amplification strategy employing methylene blue is developed as a potential tool for the detection of miRNA-21.

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Optimization of the Electrodeposition of Gold Nanoparticles for the Application of Highly Sensitive, Label-Free Biosensor

Biosensors ◽

10.3390/bios9020050 ◽

2019 ◽

Vol 9 (2) ◽

pp. 50 ◽

Cited By ~ 3

Author(s):

Hao-Chun Chiang ◽

Yanyan Wang ◽

Qi Zhang ◽

Kalle Levon

Keyword(s):

Gold Nanoparticles ◽

Signal Amplification ◽

Electrochemical Biosensor ◽

Aqueous Electrolyte ◽

Label Free ◽

Reduction Step ◽

Glucose Biosensors ◽

Highly Sensitive ◽

Amperometric Glucose Biosensors ◽

Aunp Surface

A highly sensitive electrochemical biosensor with a signal amplification platform of electrodeposited gold nanoparticle (AuNP) has been developed and characterized. The sizes of the synthesized AuNP were found to be critical for the performance of biosensor in which the sizes were dependent on HAuCl4 and acid concentrations; as well as on scan cycles and scan rates in the gold electro-reduction step. Systematic investigations of the adsorption of proteins with different sizes from aqueous electrolyte solution onto the electrodeposited AuNP surface were performed with a potentiometric method and calibrated by design of experiment (DOE). The resulting amperometric glucose biosensors was demonstrated to have a low detection limit (> 50 μM) and a wide linear range after optimization with AuNP electrodeposition.

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A novel chemiluminescence signal amplification strategy based on a capillary electrophoresis platform for highly sensitive competitive immunoassay of biomolecules

Analytical Methods ◽

10.1039/c8ay01987h ◽

2018 ◽

Vol 10 (46) ◽

pp. 5499-5506 ◽

Cited By ~ 1

Author(s):

Min Shi ◽

Jingjin Zhao ◽

Shuting Li ◽

Jianniao Tian ◽

Shulin Zhao

Keyword(s):

Gold Nanoparticles ◽

Capillary Electrophoresis ◽

Signal Amplification ◽

Competitive Immunoassay ◽

Highly Sensitive ◽

Amplification Strategy

A novel chemiluminescence (CL) signal amplification strategy based on luminophore and antigen co-loaded gold nanoparticles was developed to improve the sensitivity of capillary electrophoresis CL assay.

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Highly Sensitive Immunosensing of Carcinoembryonic Antigen Based on Gold Nanoparticles Functionalized PB@PANI Core-Shell Nanocubes as a Novel Signal Amplification Strategy

SSRN Electronic Journal ◽

10.2139/ssrn.3929227 ◽

2021 ◽

Author(s):

Dexiang Feng ◽

Lingzhi Chen ◽

Menglan Fu ◽

Peng Jiang ◽

Xianhao Jiang ◽

...

Keyword(s):

Gold Nanoparticles ◽

Carcinoembryonic Antigen ◽

Signal Amplification ◽

Core Shell ◽

Highly Sensitive ◽

Amplification Strategy

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A novel electrochemical immunosensor based on dual signal amplification of gold nanoparticles and telomerase extension reaction

Analytical Methods ◽

10.1039/c3ay42237b ◽

2014 ◽

Vol 6 (7) ◽

pp. 2221-2226 ◽

Cited By ~ 2

Author(s):

Xiao-Yan Li ◽

Zi Yi ◽

Hao Tang ◽

Xia Chu ◽

Ru-Qin Yu

Keyword(s):

Gold Nanoparticles ◽

Signal Amplification ◽

Electrochemical Immunosensor ◽

Highly Sensitive ◽

Dual Signal Amplification

Highly sensitive electrochemical immune analysis was achieved based on dual signal amplification of AuNPs and telomerase extension reaction.

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Electrochemical biosensor for detection of pathogenic bacteria based on dual signal amplification of Cu3(PO4)2-mediated click chemistry and DNAzyme

The Analyst ◽

10.1039/d1an00982f ◽

2021 ◽

Author(s):

Hongguo Wei ◽

Jiayu Wan ◽

Shengjun Bu ◽

Wenguang Zhang ◽

Ma Li ◽

...

Keyword(s):

Click Chemistry ◽

Magnetic Separation ◽

Concanavalin A ◽

Signal Amplification ◽

Pathogenic Bacteria ◽

Electrochemical Biosensor ◽

Inorganic Hybrid ◽

Highly Sensitive ◽

Antibody Conjugates ◽

Dual Signal Amplification

A novel electrochemical biosensor for detecting pathogenic bacteria was designed based on specific magnetic separation and highly sensitive click chemistry. Instead of enzyme-antibody conjugates, organic-inorganic hybrid nanoflowers (Concanavalin A (Con...

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