Modified Cytosines versus Cytosine in a DNA Polymerase: Retrieving Thermodynamic and Kinetic Constants at the Single Molecule Level

The Analyst ◽  
2022 ◽  
Author(s):  
Ji Yoon Lee ◽  
Joon Won Park
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Dna Polymerase ◽  
Single Molecule ◽  
Gene Expression Regulation ◽  
Expression Regulation ◽  
Kinetic Constants ◽  
Binding Kinetics ◽  
Single Molecule Level ◽  
Methylated Dna

DNA methylation plays key roles in various areas, such as gene expression, regulation, epigenetics, and cancers. Since 5-methylcytosine (5mC) is commonly present in methylated DNA, characterizing the binding kinetics and...

The complex interplay between DNA methylation and miRNAs in gene expression regulation

Biochimie ◽  
2020 ◽  
Vol 173 ◽  
pp. 12-16 ◽  
Author(s):  
Andrea Fuso ◽  
Tiziana Raia ◽  
Michela Orticello ◽  
Marco Lucarelli
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Gene Expression Regulation ◽  
Expression Regulation ◽  
Complex Interplay

scholarly journals Single-Cell and Single-Molecule Analysis of Gene Expression Regulation

2016 ◽  
Vol 50 (1) ◽  
pp. 267-291 ◽  
Author(s):  
Maria Vera ◽  
Jeetayu Biswas ◽  
Adrien Senecal ◽  
Robert H. Singer ◽  
Hye Yoon Park
Keyword(s):  
Gene Expression ◽  
Single Cell ◽  
Single Molecule ◽  
Gene Expression Regulation ◽  
Expression Regulation ◽  
Single Molecule Analysis

scholarly journals Distinctive Nuclear Features of Dinoflagellates with A Particular Focus on Histone and Histone-Replacement Proteins

2018 ◽  
Vol 6 (4) ◽  
pp. 128 ◽  
Author(s):  
Sadaf Riaz ◽  
Zhenghong Sui ◽  
Zeeshan Niaz ◽  
Sohrab Khan ◽  
Yuan Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Harmful Algal Blooms ◽  
Algal Blooms ◽  
Gene Expression Regulation ◽  
Expression Regulation ◽  
Histone Proteins ◽  
Methylated Dna ◽  
Low Protein ◽  
Eukaryotic Microorganisms ◽  
Nuclear Features

Dinoflagellates are important eukaryotic microorganisms that play critical roles as producers and grazers, and cause harmful algal blooms. The unusual nuclei of dinoflagellates “dinokaryon” have led researchers to investigate their enigmatic nuclear features. Their nuclei are unusual in terms of their permanently condensed nucleosome-less chromatin, immense genome, low protein to DNA ratio, guanine-cytosine rich methylated DNA, and unique mitosis process. Furthermore, dinoflagellates are the only known group of eukaryotes that apparently lack histone proteins. Over the course of evolution, dinoflagellates have recruited other proteins, e.g., histone-like proteins (HLPs), from bacteria and dinoflagellates/viral nucleoproteins (DVNPs) from viruses as histone substitutes. Expression diversity of these nucleoproteins has greatly influenced the chromatin structure and gene expression regulation in dinoflagellates. Histone replacement proteins (HLPs and DVNPs) are hypothesized to perform a few similar roles as histone proteins do in other eukaryotes, i.e., gene expression regulation and repairing DNA. However, their role in bulk packaging of DNA is not significant as low amounts of proteins are associated with the gigantic genome. This review intends to summarize the discoveries encompassing unique nuclear features of dinoflagellates, particularly focusing on histone and histone replacement proteins. In addition, a comprehensive view of the evolution of dinoflagellate nuclei is presented.

DNA Methylation, An Epigenetic Mode of Gene Expression Regulation in Reproductive Science

2014 ◽  
Vol 20 (11) ◽  
pp. 1726-1750 ◽  
Author(s):  
Rosamaria Calicchio ◽  
Ludivine Doridot ◽  
Francisco Miralles ◽  
Celine Mehats ◽  
Daniel Vaiman
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Gene Expression Regulation ◽  
Expression Regulation ◽  
Reproductive Science

scholarly journals DNA methylation and gene expression regulation associated with vascularization in Sorghum bicolor

2017 ◽  
Vol 214 (3) ◽  
pp. 1213-1229 ◽  
Author(s):  
Gina M. Turco ◽  
Kaisa Kajala ◽  
Govindarajan Kunde-Ramamoorthy ◽  
Chew-Yee Ngan ◽  
Andrew Olson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Sorghum Bicolor ◽  
Gene Expression Regulation ◽  
Expression Regulation
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