scholarly journals Base-catalysed 18F-labelling of trifluoromethyl ketones. Application to the synthesis of 18F-labelled neutrophil elastase inhibitors

2021 ◽  
Author(s):  
Denise N. Meyer ◽  
Miguel A. Cortés González ◽  
Xingguo Jiang ◽  
Linus Johansson-Holm ◽  
Monireh Pourghasemi Lati ◽  
...  
Keyword(s):  
Neutrophil Elastase ◽  
Functional Group ◽  
New Method ◽  
Trifluoromethyl Ketones ◽  
18F Labelling

A new method for the fluorine-18 labelling of trifluoromethyl ketones has been developed. This method is based on the conversion of a COCF3 functional group to a difluoro enol silyl...

Enantioselective alpha-Arylation of Benzamides via Synergistic Nickel and Metallaphotoredox Catalysis

2019 ◽  
Author(s):  
John Montgomery ◽  
Alexander W. Rand
Keyword(s):  
Catalytic System ◽  
Functional Group ◽  
Enantiomeric Excess ◽  
New Method ◽  
Aryl Bromides

A new method to access alpha-arylated benzamides has been enabled by metallaphotoredox catalysis. This system allows for non-directed C–H functionalization of N-alkyl benzamides using a dual nickel/iridium catalytic system to form tertiary stereocenters in good enantiomeric excess and moderate yields. This reaction shows excellent functional group compatibility and can be performed using a number of sterically and electronically different aryl bromides and secondary benzamides.

Enantioselective alpha-Arylation of Benzamides via Synergistic Nickel and Metallaphotoredox Catalysis

2019 ◽  
Author(s):  
John Montgomery ◽  
Alexander W. Rand
Keyword(s):  
Catalytic System ◽  
Functional Group ◽  
Enantiomeric Excess ◽  
New Method ◽  
Aryl Bromides

A new method to access alpha-arylated benzamides has been enabled by metallaphotoredox catalysis. This system allows for non-directed C–H functionalization of N-alkyl benzamides using a dual nickel/iridium catalytic system to form tertiary stereocenters in good enantiomeric excess and moderate yields. This reaction shows excellent functional group compatibility and can be performed using a number of sterically and electronically different aryl bromides and secondary benzamides.

Direct and metal-free oxidative amination of sp3 C–H bonds for the construction of 2-hetarylquinazolin-4(3H)-ones

2016 ◽  
Vol 3 (9) ◽  
pp. 1096-1099 ◽  
Author(s):  
Huanhuan Liu ◽  
Tianran Zhai ◽  
Shiteng Ding ◽  
Yalei Hou ◽  
Xiangyu Zhang ◽  
...  
Keyword(s):  
Transition Metal ◽  
Functional Group ◽  
New Method ◽  
Oxidative Amination ◽  
Metal Free ◽  
Mild Conditions

New method for synthesis of 2-hetarylquinazolin-4(3H)-ones from 2-aminobenzamides and (2-azaaryl)methanes under transition-metal free conditions, featuring a wide substrate scope with a broad range of functional group tolerance under mild conditions.

Fast construction of dianthraceno[a,e]pentalenes for OPV applications

2017 ◽  
Vol 4 (5) ◽  
pp. 711-716 ◽  
Author(s):  
Zhongbo Zhang ◽  
Haijun Fan ◽  
Xiaozhang Zhu
Keyword(s):  
Functional Group ◽  
New Method ◽  
Tandem Reaction ◽  
Palladium Catalyzed

A new method based on a palladium-catalyzed tandem reaction for the fast construction of a dianthraceno[a,e]pentalene (DAP) framework is developed, which gave a series of dianthraceno[a,e]pentalenes with good functional group tolerance, and it should be highlighted that five C–C bonds were formed in one reaction.

Catalyst-Controlled C–H Functionalization of Adamantanes using Selective H-Atom Transfer

2019 ◽  
Author(s):  
Hai-Bin Yang ◽  
Abigail Feceu ◽  
David Martin
Keyword(s):  
Functional Group ◽  
New Method ◽  
Alkylation Reaction ◽  
Atom Transfer ◽  
Broad Scope ◽  
Direct Functionalization ◽  
Photochemical Systems ◽  
Substrate Competition

<p>A new method for the direct functionalization of diamondoids has been developed using photoredox and H-atom transfer catalysis. This C–H alkylation reaction has excellent chemoselectivity for the strong 3º C–H bonds of adamantanes in polyfunctional molecules. In substrate competition reactions, a reversal in selectivity is observed for the new H-atom transfer catalyst reported here when compared to six known photochemical systems. Derivatization of a broad scope of diamondoids and adamantane-containing drugs highlights the versatility and functional group tolerance of this C–H functionalization strategy.</p>

Catalyst-Controlled C–H Functionalization of Adamantanes using Selective H-Atom Transfer

2019 ◽  
Author(s):  
Hai-Bin Yang ◽  
Abigail Feceu ◽  
David Martin
Keyword(s):  
Functional Group ◽  
New Method ◽  
Alkylation Reaction ◽  
Atom Transfer ◽  
Broad Scope ◽  
Direct Functionalization ◽  
Photochemical Systems ◽  
Substrate Competition

<p>A new method for the direct functionalization of diamondoids has been developed using photoredox and H-atom transfer catalysis. This C–H alkylation reaction has excellent chemoselectivity for the strong 3º C–H bonds of adamantanes in polyfunctional molecules. In substrate competition reactions, a reversal in selectivity is observed for the new H-atom transfer catalyst reported here when compared to six known photochemical systems. Derivatization of a broad scope of diamondoids and adamantane-containing drugs highlights the versatility and functional group tolerance of this C–H functionalization strategy.</p>

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