Base-catalysed 18F-labelling of trifluoromethyl ketones. Application to the synthesis of 18F-labelled neutrophil elastase inhibitors

A new method for the fluorine-18 labelling of trifluoromethyl ketones has been developed. This method is based on the conversion of a COCF3 functional group to a difluoro enol silyl...

The efficiency of 18F labelling of a prostate specific membrane antigen ligand via strain-promoted azide–alkyne reaction: reaction speed versus hydrophilicity

Here we report the 18F labeling of a prostate specific membrane antigen ligand via a strain promoted oxa-dibenzocyclooctyne- or bicyclo[6.1.0]nonyne-azide reaction.

18F-Labelling of electron rich iodonium ylides: application to the radiosynthesis of potential 5-HT2A receptor PET ligands

Nucleophilic 18F-labelling of electron aromatic systems.

A two-step fluorinase enzyme mediated 18F labelling of an RGD peptide for positron emission tomography

Fluorine-18 radiolabelling of a peptide is conducted in water (pH 7.8 and 37 °C) using the fluorinase enzyme and a ‘click’ reaction.

Sonogashira cross-coupling reaction with 4-[18F]fluoroiodobenzene for rapid 18F-labelling of peptides

The study describes the Sonogashira cross-coupling reaction with 4-[18F]fluoroiodobenzene ([18F]FIB) as novel and efficient method for rapid labelling of peptides with the short-lived positron emitter fluorine-18.