A novel FRET-based dendritic hybridization chain reaction for tumour-related mRNA imaging

A novel FRET-based dendritic hybridization chain reaction (D-HCR) for TK1 mRNA imaging was developed in living cells. Compared to the traditional complex D-HCR methods, it has the following advantages, including...

Imaging of Receptor Dimers in Zebrafish and Living Cells via Aptamer Recognition and Proximity-Induced Hybridization Chain Reaction

Analytical Chemistry ◽

10.1021/acs.analchem.8b04015 ◽

2018 ◽

Vol 90 (24) ◽

pp. 14433-14438 ◽

Cited By ~ 14

Author(s):

Liping Wang ◽

Wei Li ◽

Jin Sun ◽

Su-Yun Zhang ◽

Sheng Yang ◽

...

Keyword(s):

Living Cells ◽

Chain Reaction ◽

Receptor Dimers

Branched Hybridization Chain Reaction Circuit for Ultrasensitive Localizable Imaging of mRNA in Living Cells

Analytical Chemistry ◽

10.1021/acs.analchem.7b04848 ◽

2018 ◽

Vol 90 (3) ◽

pp. 1502-1505 ◽

Cited By ~ 45

Author(s):

Lan Liu ◽

Jin-Wen Liu ◽

Han Wu ◽

Xiang-Nan Wang ◽

Ru-Qin Yu ◽

...

Keyword(s):

Living Cells ◽

A hybridization chain reaction amplification strategy for fluorescence imaging of human telomerase activity in living cells

Methods and Applications in Fluorescence ◽

10.1088/2050-6120/aacded ◽

2018 ◽

Vol 6 (4) ◽

pp. 045003 ◽

Cited By ~ 3

Author(s):

Zhiqian Zhang ◽

Changli Zhong ◽

Taixian Yuan ◽

Xiaoyan Zhou ◽

Min Zhao ◽

...

Keyword(s):

Fluorescence Imaging ◽

Telomerase Activity ◽

Living Cells ◽

Chain Reaction ◽

Reaction Amplification ◽

Human Telomerase ◽

Amplification Strategy

A proximity-exponential hybridization chain reaction (PEHCR) and its application for nondestructive analysis of membrane protein-protein interactions on living cells

Analytica Chimica Acta ◽

10.1016/j.aca.2020.05.024 ◽

2020 ◽

Vol 1125 ◽

pp. 8-18

Author(s):

Dongsheng Mao ◽

Tianshu Chen ◽

Xiaohao Liu ◽

Lingjie Ren ◽

Chang Feng ◽

...

Keyword(s):

Membrane Protein ◽

Protein Interactions ◽

Living Cells ◽

Nondestructive Analysis ◽

Protein Protein Interactions ◽

Multiple amplified MicroRNAs monitoring in living cells based on fluorescence quenching of Mo2B and hybridization chain reaction

Biosensors and Bioelectronics ◽

10.1016/j.bios.2021.113815 ◽

2021 ◽

pp. 113815

Author(s):

Shah Zada ◽

Huiting Lu ◽

Wenhao Dai ◽

Songsong Tang ◽

Sikandar Khan ◽

...

Keyword(s):

Fluorescence Quenching ◽

Living Cells ◽

A proteinase-free DNA replication machinery for in vitro and in vivo amplified MicroRNA imaging

Nucleic Acids Research ◽

10.1093/nar/gkaa250 ◽

2020 ◽

Vol 48 (10) ◽

pp. e60-e60 ◽

Cited By ~ 6

Author(s):

Jie Wei ◽

Huimin Wang ◽

Xue Gong ◽

Qing Wang ◽

Hong Wang ◽

...

Keyword(s):

Dna Replication ◽

Living Cells ◽

Replication Machinery ◽

Chain Reaction ◽

Free Dna ◽

Sensing Platform ◽

Dna Machine

Abstract The construction of robust, modular and compact DNA machinery facilitates us to build more intelligent and ingenious sensing strategies in complex biological systems. However, the performance of conventional DNA amplifiers is always impeded by their limited in-depth amplifications and miscellaneously enzymatic requirements. Here, a proteinase-free reciprocal DNA replication machinery is developed by exploiting the synergistic cross-activation between hybridization chain reaction (HCR) and DNAzyme. The DNAzyme provides an efficient way to simplify the sophisticated design of HCR machinery and simultaneously to promote the amplification capacity. And the HCR-assembled tandem DNAzyme nanowires produce numerous new triggers for reversely stimulating HCR amplifier as systematically explored by experiments and computer-aided simulations. The reciprocal amplifier can be executed as a versatile and powerful sensing platform for analyzing miRNA in living cells and even in mice, originating from the inherent reaction accelerations and multiple-guaranteed recognitions. The reciprocal catalytic DNA machine holds great potential in clinical diagnosis and assessment.

Graphene Oxide Biosensors Based on Hybridization Chain Reaction Signal Amplification for Detecting Biomarkers of Radiation-Resistant Nasopharyngeal Carcinoma and Imaging in Living Cells

Langmuir ◽

10.1021/acs.langmuir.1c00406 ◽

2021 ◽

Author(s):

Lan Qin ◽

Dutao Yang ◽

Shaoxian Yin ◽

Yue Qian ◽

Yanfei Cai ◽

...

Keyword(s):

Graphene Oxide ◽

Nasopharyngeal Carcinoma ◽

Signal Amplification ◽

Living Cells ◽

Chain Reaction ◽

Radiation Resistant

Three-dimensional DNA nanostructures for dual-color microRNA imaging in living cells via hybridization chain reaction

Chemical Communications ◽

10.1039/d0cc01626h ◽

2020 ◽

Vol 56 (49) ◽

pp. 6668-6671

Author(s):

Meng-Mei Lv ◽

Zhan Wu ◽

Ru-Qin Yu ◽

Jian-Hui Jiang

Keyword(s):

Three Dimensional ◽

Living Cells ◽

Fluorescent Imaging ◽

Dna Nanostructures ◽

Chain Reaction ◽

Dna Nanostructure ◽

Dual Color ◽

Dna Tetrahedron

A well-defined 3D DNA nanostructure was developed by combination of DNA tetrahedron and Y-shaped DNA, which allowed multiplexed, signal amplified fluorescent imaging of miRNAs in living cells via hybridization chain reaction.