Biodegradable MnO2 nanosheet mediated hybridization chain reaction for imaging of human apurinic/apyrimidinic endonuclease 1 activity in living cells

Nanoscale ◽  
2019 ◽  
Vol 11 (43) ◽  
pp. 20456-20460 ◽  
Author(s):  
Guangli Li ◽  
Junjie Li ◽  
Qing Li
Keyword(s):  
Living Cells ◽  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Highly Sensitive ◽  
Amplification Assay ◽  
Mno2 Nanosheet

A highly sensitive enzyme-free amplification assay for the detection of apurinic/apyrimidinic endonuclease 1 activity was developed.

scholarly journals Two-color imaging of microRNA with enzyme-free signal amplification via hybridization chain reactions in living cells

2016 ◽  
Vol 7 (3) ◽  
pp. 1940-1945 ◽  
Author(s):  
Lu Li ◽  
Jie Feng ◽  
Haiyun Liu ◽  
Qingling Li ◽  
Lili Tong ◽  
...  
Keyword(s):  
Disease Diagnosis ◽  
Living Cells ◽  
Hybridization Chain Reaction ◽  
Early Disease ◽  
Chain Reaction ◽  
Chain Reactions ◽  
Simultaneous Imaging ◽  
Highly Sensitive ◽  
Amplification Strategy ◽  
Non Destructive

Here, a non-destructive amplification strategy is developed to image miRNAs in living cells, utilizing the enzyme-free hybridization chain reaction (HCR) with graphene oxide (GO) as a carrier. This provides a new tool for highly sensitive and simultaneous imaging of multiple low-level biomarkers, improving the accuracy of early disease diagnosis.

Lab in a tube: a fast-assembled colorimetric sensor for highly sensitive detection of oligonucleotides based on a hybridization chain reaction

RSC Advances ◽  
2015 ◽  
Vol 5 (55) ◽  
pp. 44714-44721 ◽  
Author(s):  
Siqi Zhang ◽  
Kun Wang ◽  
Zhenyu Li ◽  
Zhongmin Feng ◽  
Ting Sun
Keyword(s):  
Complex Formation ◽  
Dna Sequence ◽  
Self Assembly ◽  
The Self ◽  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Highly Sensitive ◽  
G Quadruplex ◽  
Colored Product ◽  
Highly Sensitive Detection

Upon adding THBV, the self-assembly of THBV with H1 allows the rest of the DNA sequence of H1 to accelerate H1–H2 complex formation. The G-quadruplex at the end of the H1–H2 complex could catalyze TMB into a colored product.

Imaging of Receptor Dimers in Zebrafish and Living Cells via Aptamer Recognition and Proximity-Induced Hybridization Chain Reaction

2018 ◽  
Vol 90 (24) ◽  
pp. 14433-14438 ◽  
Author(s):  
Liping Wang ◽  
Wei Li ◽  
Jin Sun ◽  
Su-Yun Zhang ◽  
Sheng Yang ◽  
...  
Keyword(s):  
Living Cells ◽  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Receptor Dimers

A novel FRET-based dendritic hybridization chain reaction for tumour-related mRNA imaging

2022 ◽  
Author(s):  
Shiyuan Liu ◽  
Zhenxiang Liu ◽  
Huimin Wang ◽  
Jiaoli Wang ◽  
Ruiting Liu ◽  
...  
Keyword(s):  
Living Cells ◽  
Hybridization Chain Reaction ◽  
Chain Reaction

A novel FRET-based dendritic hybridization chain reaction (D-HCR) for TK1 mRNA imaging was developed in living cells. Compared to the traditional complex D-HCR methods, it has the following advantages, including...

scholarly journals Branched Hybridization Chain Reaction Circuit for Ultrasensitive Localizable Imaging of mRNA in Living Cells

2018 ◽  
Vol 90 (3) ◽  
pp. 1502-1505 ◽  
Author(s):  
Lan Liu ◽  
Jin-Wen Liu ◽  
Han Wu ◽  
Xiang-Nan Wang ◽  
Ru-Qin Yu ◽  
...  
Keyword(s):  
Living Cells ◽  
Hybridization Chain Reaction ◽  
Chain Reaction

scholarly journals Highly sensitive detection of lipopolysaccharides using an aptasensor based on hybridization chain reaction

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Peiyan Xie ◽  
Longjiao Zhu ◽  
Xiangli Shao ◽  
Kunlun Huang ◽  
Jingjing Tian ◽  
...  
Keyword(s):  
Sensitive Detection ◽  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Highly Sensitive ◽  
Highly Sensitive Detection
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