Synthesis and Biological Evaluation of Ruthenium Polypyridine Complexes with 18β-Glycyrrhetinic Acid as Antibacterial Agents against Staphylococcus aureus

2021 ◽  
Author(s):  
Qin Zhang ◽  
Yan-Shi Xiong ◽  
Jianxin Chen ◽  
Yanhui Tan ◽  
Xiangwen Liao ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Agents ◽  
Biological Evaluation ◽  
Glycyrrhetinic Acid ◽  
Tert Butyl ◽  
Polypyridine Complexes ◽  
Ruthenium Polypyridine ◽  
Synthesis And Biological Evaluation

Abstract Four new ruthenium (II) polypyridine complexes bearing 18β-glycyrtinic acid derivatives, [Ru(bpy)2L](PF6)2 (Ru1), [Ru(dmb)2L](PF6)2 (Ru2), [Ru(dtb)2L](PF6)2 (Ru3) and [Ru(phen)2L](PF6)2 (Ru4) (bpy = 2,2-bipyridine, dmb = 4,4'-dimethyl-2,2'-bipyridine, dtb = 4,4'-di-tert-butyl-2,2'-bipyridine, phen...

scholarly journals Synthesis and biological evaluation of truncated derivatives of abyssomicin C as antibacterial agents

2019 ◽  
Vol 15 ◽  
pp. 1468-1474
Author(s):  
Leticia Monjas ◽  
Peter Fodran ◽  
Johanna Kollback ◽  
Carlo Cassani ◽  
Thomas Olsson ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Natural Product ◽  
Antibacterial Agents ◽  
Biological Evaluation ◽  
Methicillin Resistant ◽  
Structure Activity ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of ◽  
Novel Antibiotics

The synthesis and antibacterial activity of two new highly truncated derivatives of the natural product abyssomicin C are reported. This work outlines the limits of structural truncation of the natural product and consequently provides insights for further structure–activity relationship studies towards novel antibiotics targeting 4-amino-4-deoxychorismate (ADC) synthase. Specifically, it is demonstrated that the synthetically challenging bicyclic motif is essential for activity towards methicillin-resistant Staphylococcus aureus (MRSA).

Synthesis and Biological Evaluation of a New Series of Benzothiazole-Quinolone Hybrids as Antibacterial Agents

2008 ◽  
Vol 5 (5) ◽  
pp. 353-357 ◽  
Author(s):  
Ahmed Kamal ◽  
S. Ahmed ◽  
M. A. Khan ◽  
Rajesh Shetty ◽  
B. Siddhardha ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and Biological Evaluation of Fingolimod Derivatives as Antibacterial Agents

ACS Omega ◽  
2021 ◽  
Author(s):  
Matej Zore ◽  
Shella Gilbert-Girard ◽  
Inés Reigada ◽  
Jayendra Z. Patel ◽  
Kirsi Savijoki ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Synthesis and Biological Evaluation of 8-Aminomethyltetracycline Derivatives as Novel Antibacterial Agents

2013 ◽  
Vol 56 (20) ◽  
pp. 8112-8138 ◽  
Author(s):  
Roger B. Clark ◽  
Minsheng He ◽  
Yonghong Deng ◽  
Cuixiang Sun ◽  
Chi-Li Chen ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and Hydrazones

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Vu Van Vu ◽  
Trinh Thi Nhung ◽  
Nguyen Thi Thanh ◽  
Luu Van Chinh ◽  
Vu Dinh Tien ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Schiff Bases ◽  
Cell Lines ◽  
Human Cancer ◽  
Structural Data ◽  
Biological Evaluation ◽  
Human Cancer Cell Lines ◽  
High Yields ◽  
Synthesis And Biological Evaluation

A series of 14 new (-)-gossypol Schiff bases and hydrazones have been synthesized via an in situ procedure in high yields. Structural data showed that all target compounds exist as the enamine tautomer. Bioassays showed that several compounds exhibited cytotoxic effects against three human cancer cell lines. Compound 8a showed the greatest cytotoxic effect against hepatocellular carcinoma (HepG2), lung carcinoma (LU-1), and breast cancer (MCF-7) cell lines with IC50 values of 20.93, 13.58, and 9.40 μM, respectively. However, in an antibacterial test, compounds 8a and 8b inhibited Staphylococcus aureus and Bacillus cereus and compound 8e inhibited only Staphylococcus aureus at the same MIC values of 1024 μg/ml.

scholarly journals Eco-sustainable synthesis and biological evaluation of 2-phenyl 1,3-benzodioxole derivatives as anticancer, DNA binding and antibacterial agents

2016 ◽  
Vol 9 ◽  
pp. S1875-S1883 ◽  
Author(s):  
Sayan Dutta Gupta ◽  
Ganga Balaji Rao ◽  
Manish Kumar Bommaka ◽  
Nulgumnalli Manjunathaiah Raghavendra ◽  
Swapna Aleti
Keyword(s):  
Dna Binding ◽  
Antibacterial Agents ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Design, Synthesis, and Biological Evaluation of Hexacyclic Tetracyclines as Potent, Broad Spectrum Antibacterial Agents

2015 ◽  
Vol 58 (11) ◽  
pp. 4703-4712 ◽  
Author(s):  
Cuixiang Sun ◽  
Diana K. Hunt ◽  
Chi-Li Chen ◽  
Yonghong Deng ◽  
Minsheng He ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation
Sign in / Sign up

Export Citation Format

Share Document