scholarly journals The garlic-derived organosulfur compound diallyl trisulphide suppresses tissue factor function

2022 ◽  
Author(s):  
Sachiko Okue ◽  
Manami Yaguchi ◽  
Atsushi Miura ◽  
Yori Ozaki-Masuzawa ◽  
Takashi Hosono ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Secondary Metabolite ◽  
Organosulfur Compound ◽  
Diallyl Trisulfide ◽  
Factor Function

Tissue factor (TF) is a critical initiator of extrinsic coagulation that sometimes causes thromboembolism. Diallyl trisulfide (DATS) is a secondary metabolite of allicin generated in crushed garlic, with various pharmacological...

scholarly journals A monoclonal antibody that inhibits mouse tissue factor function

2005 ◽  
Vol 3 (5) ◽  
pp. 1098-1099 ◽  
Author(s):  
D. KIRCHHOFER ◽  
P. MORAN ◽  
S. BULLENS ◽  
F. PEALE ◽  
S. BUNTING
Keyword(s):  
Monoclonal Antibody ◽  
Tissue Factor ◽  
Mouse Tissue ◽  
Factor Function

Can diallyl trisulfide, a dietary garlic-derived compound, activate ferroptosis to overcome therapy resistance in prostate cancer?

2021 ◽  
pp. 026010602110183
Author(s):  
Angela Lincy Prem Antony Samy ◽  
Dhruvi Shah ◽  
Preksha Shahagadkar ◽  
Hillary Shah ◽  
Gnanasekar Munirathinam
Keyword(s):  
Prostate Cancer ◽  
Cell Death ◽  
Organosulfur Compound ◽  
Underlying Mechanism ◽  
Therapy Resistance ◽  
In Vivo Studies ◽  
Diallyl Trisulfide ◽  
Apoptosis Resistance

Background: Therapy resistance is the underlying reason for poor outcome in prostate cancer (PCa) patients. Diallyl trisulfide (DATS) is an organosulfur compound present in garlic. DATS has been shown to target PCa cells by induction of apoptosis, increase in the production of reactive oxygen species, degradation of ferritin protein and increase in the labile iron (Fe) pool. Aim: We hypothesize that DATS could induce ferroptosis, an Fe-dependent, unique non-apoptotic form of regulated cell death to eliminate therapy resistance encountered by PCa patients. Methods: In vitro and in vivo studies should be performed to test the hypothesis. Results: As per the hypothesis, DATS would eliminate apoptotic resistance via inducing ferroptosis. Conclusion: Since apoptosis resistance has been reported to be the underlying mechanism of therapy resistance in PCa, DATS could be used to effectively target PCa cells by overcoming apoptosis resistance and inducing ferroptosis-mediated cell death of PCa cells.

Targeting secondary metabolite biosynthetic genes from the metagenome of the sponge Mycale sp

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
SA Van der Sar ◽  
KM Fisch ◽  
C Gurgui ◽  
TA Nguyen ◽  
J Piel ◽  
...  
Keyword(s):  
Secondary Metabolite ◽  
Biosynthetic Genes
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