Effects of type II collagen hydrolysates on osteoarthritis through NF-ĸB, Wnt/β-catenin and MAPK pathways

2022 ◽  
Author(s):  
Li Hao ◽  
Chengcheng Ma ◽  
Zhaoxia Li ◽  
Yanchao Wang ◽  
Xue Zhao ◽  
...  
Keyword(s):  
Medial Collateral Ligament ◽  
Rat Model ◽  
Medial Meniscus ◽  
Type Ii Collagen ◽  
Degenerative Disease ◽  
Type Ii ◽  
Collateral Ligament ◽  
Mapk Pathways ◽  
The World ◽  
Collagen Hydrolysates

Osteoarthritis (OA), a degenerative disease, has attracted extensive attention all over the world. In the study, medial meniscus resection (MMx) and anterior to medial collateral ligament (ACL) operation rat model...

Healing of Circular Defects in the Rabbit Medial Meniscus Can Occur Spontaneously and Is not Improved by Intra-Articular Hyaluronic Acid

1996 ◽  
Vol 09 (02) ◽  
pp. 60-5 ◽  
Author(s):  
N. Hope ◽  
P. Ghosh ◽  
S. Collier
Keyword(s):  
Hyaluronic Acid ◽  
Medial Meniscus ◽  
Chondroitin Sulphate ◽  
Rabbit Model ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Keratan Sulphate ◽  
Meniscal Healing ◽  
Meniscus Healing ◽  
Made In

SummaryThe aim of this study was to determine the effects of intra-articular hyaluronic acid on meniscal healing. Circular defects, 1.0 mm in diameter, were made in the anterior third of the medial meniscus in rabbits. In one joint, 0.4 ml hyaluronic acid (Healon®) was instilled, and in the contralateral (control) joint, 0.4 ml Ringer’s saline. Four rabbits were killed after four, eight and 12 weeks and the menisci examined histologically. By eight weeks most of the lesions had healed by filling with hyaline-like cartilage. Healing was not improved by hyaluronic acid treatment. The repair tissue stained strongly with alcian blue, and the presence of type II collagen, keratan sulphate, and chondroitin sulphate was demonstrated by immunohistochemical localisation. In contrast to the circular defects, longitudinal incisions made in the medial menisci of a further six rabbits did not show any healing after 12 weeks, indicating that the shape of the lesion largely determined the potential for healing.The effect of hyaluronic acid on meniscal healing was tested in a rabbit model. With one millimeter circular lesions in the medial meniscus, healing by filling with hyalinelike cartilage was not significantly affected by the application of hyaluronic acid intra-articularly at the time of surgery, compared to saline controls, as assessed histologically four, eight and 12 weeks after the operation.

Compressive compared with tensile loading of medial collateral ligament scarin vitro uniquely influences mRNA levels for aggrecan, collagen type II, and collagenase

2000 ◽  
Vol 18 (4) ◽  
pp. 524-531 ◽  
Author(s):  
Tokifumi Majima ◽  
Linda L. Marchuk ◽  
Paul Sciore ◽  
Nigel G. Shrive ◽  
Cyril B. Frank ◽  
...  
Keyword(s):  
Medial Collateral Ligament ◽  
Collagen Type ◽  
Tensile Loading ◽  
Mrna Levels ◽  
Type Ii ◽  
Collagen Type Ii ◽  
Collateral Ligament

scholarly journals 17β-Estradiol inhibits intervertebral disc degeneration by down-regulating MMP-3 and MMP-13 and up-regulating type II collagen in a rat model

2018 ◽  
Vol 46 (sup2) ◽  
pp. 182-191 ◽  
Author(s):  
Sen Liu ◽  
Si-Dong Yang ◽  
Xi-Wei Huo ◽  
Da-Long Yang ◽  
Lei Ma ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Rat Model ◽  
Intervertebral Disc Degeneration ◽  
Type Ii Collagen ◽  
Type Ii ◽  
17Β Estradiol

scholarly journals Acceleration of healing of the medial collateral ligament of the knee by local administration of synthetic microRNA-210 in a rat model

2015 ◽  
Vol 2 (4) ◽  
pp. 129-136
Author(s):  
Muhammad Sakti ◽  
Tomoyuki Nakasa ◽  
Takeshi Shoji ◽  
Muhammad Andry Usman ◽  
Yoshitaka Kawanishi ◽  
...  
Keyword(s):  
Medial Collateral Ligament ◽  
Rat Model ◽  
Local Administration ◽  
Collateral Ligament

scholarly journals Outside-In Deep Medial Collateral Ligament Release During Arthroscopic Medial Meniscus Surgery

2016 ◽  
Vol 5 (4) ◽  
pp. e781-e785 ◽  
Author(s):  
Adrian Todor ◽  
Sergiu Caterev ◽  
Dan Viorel Nistor
Keyword(s):  
Medial Collateral Ligament ◽  
Medial Meniscus ◽  
Collateral Ligament ◽  
Meniscus Surgery

scholarly journals Tibial Avulsion with Intra-Articular Entrapment of Medial Collateral Ligament with Posterior Cruciate Ligament Tear with Posterior Root Medial Meniscus Tear: A Case Report of an Unusual Injury Triad

2021 ◽  
Vol 11 (8) ◽  
Author(s):  
Ishan Shevate ◽  
Girish Nathani ◽  
Ashwin Deshmukh ◽  
Anirudh Kandari
Keyword(s):  
Case Report ◽  
Medial Collateral Ligament ◽  
Medial Meniscus ◽  
Cruciate Ligament ◽  
Stress Test ◽  
Joint Line ◽  
Posterior Root ◽  
Collateral Ligament ◽  
Valgus Stress ◽  
Medial Knee

Introduction: The medial collateral ligament (MCL) is the most commonly injured ligament of the knee joint; however, its displacement into the medial knee compartment is rare. Traumatic posterior root of medial meniscus (PRMM) tears are commonly found in high-grade injuries involving anterior cruciate ligament (ACL) or posterior cruciate ligament (PCL) tears along with MCL tears. Diagnosis of these injuries can be made by a preoperative magnetic resonance imaging (MRI), but they can be missed at times due to severe soft-tissue swelling in the acute phase. Case Report: A 25-year-old gentleman presented with injury to the front of his left knee 5 days back. On examination, he had a Grade 3 effusion with valgus stress test and posterior drawer test being positive and medial joint line tenderness was present. A firm localized swelling was palpable on the medial joint line. MRI scan revealed a mid-substance PCL tear, ACL sprain, PRMM tear, and tibial side rupture of superficial MCL with proximally migrated wavy MCL fibers lying below the medial meniscus confirmed on arthroscopy. Medial meniscus root repair by pull through technique and PCL reconstruction with a 3-strand peroneus longus graft followed by open MCL repair with augmentation using a semitendinosus graft was performed. Postoperatively, the knee was kept in a straight knee brace for 4 weeks, followed by a hinged knee brace and appropriate physiotherapy were started. At 2 years follow-up, the patient had attained full range of knee motion with good quadriceps strength, tibial step off maintained, and negative posterior drawer test and valgus stress test. Displacement of torn MCL into the medial knee compartment is an extremely rare injury. Proximal or distal avulsion of MCL with intra-articular incarceration has been reported in isolation or associated with ACL tear. Such an injury triad as reported here has not been reported in the literature to the best of our review. Conclusion: In our case, we report a ver

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