Efficient O-phthalaldehyde-amine Coupling Reaction for the Synthesis of Bottlebrush Polymer under Physiological Conditions

2021 ◽  
Author(s):  
Jianbing Huang ◽  
Mao Shi ◽  
Hui Liang ◽  
Lu Jiang
Keyword(s):  
Coupling Reaction ◽  
New Method ◽  
Physiological Conditions ◽  
Catalyst Free ◽  
Grafting Onto ◽  
Amine Coupling

A new method to prepare bottlebrush polymer poly(2-aminoethyl methacrylate hydrochloride)-graft-poly(N,N-dimethylacrylamide) (PAMA-g-PDMA) by the combination of “grafting onto” and catalyst-free o-phthalaldehyde (OPA)-amine coupling reaction was proposed. The PAMA backbone with primary...

Phosphonodithioformate-amine coupling reaction: from basic discovery to application for the functionalization of liposomes

2021 ◽  
pp. 1-6
Author(s):  
Montassar Khalil ◽  
Dany Jeanne Dit Fouque ◽  
Mathieu Berchel ◽  
Aurore Fraix ◽  
Salvatore Sortino ◽  
...  
Keyword(s):  
Coupling Reaction ◽  
Amine Coupling

scholarly journals High Yielding, Base Catalyzed C6 Regioselective Amination and N9 Alkylation in Purine Nucleotide

2019 ◽  
Vol 31 (12) ◽  
pp. 2871-2874
Author(s):  
Gautamkumar Dhuda ◽  
Khushal Kapadiya ◽  
Paresh Ladwa ◽  
Bhavna Godhaniya ◽  
Jayesh Modha
Keyword(s):  
Coupling Reaction ◽  
Purine Nucleoside ◽  
Regioselective Synthesis ◽  
Secondary Amines ◽  
Purine Nucleotide ◽  
Reaction Conditions ◽  
Simple Reaction ◽  
Amine Coupling

2,6-Dichloropurine is an interesting new nucleoside which gave regioselectively various 2-derivatized or 6-derivatized purines by using a secondary amines. An efficient, simple and regioselective synthesis of C6 morpholine, N9 alkylated purine nucleoside derivatives were attained via chloro-amine coupling reaction between 2,6-dichloropurine with morpholine followed by commercial alkylation method using DMF and K2CO3. Over the traditionally used protocols and procedure, it have been exhibited advance benefits such as admirable yield, simple reaction conditions and modest influence.

A New Method for Measurement of Biliary Pharmacokinetics under Physiological Conditions in Man

1986 ◽  
Vol 70 (s13) ◽  
pp. 72P-72P
Author(s):  
A. Lanzini ◽  
G. Pigozzi ◽  
D. Facchinetti ◽  
M. Castellano ◽  
U. Guerra ◽  
...  
Keyword(s):  
New Method ◽  
Physiological Conditions

scholarly journals Grafting onto Carboxymethylcellulose by the Ion Coupling Reaction with Telechelic Polymers Having Cyclic Onium Salt Groups.

1992 ◽  
Vol 49 (10) ◽  
pp. 809-816 ◽  
Author(s):  
Yasuyuki TEZUKA ◽  
Kaoru YAEGASHI ◽  
Mami YOSHINO ◽  
Kiyokazu IMAI
Keyword(s):  
Coupling Reaction ◽  
Telechelic Polymers ◽  
Onium Salt ◽  
Grafting Onto

scholarly journals Microwave-Accelerated N-Acylation of Sulfoximines with Aldehydes under Catalyst-Free Conditions

Synthesis ◽  
2020 ◽  
Vol 52 (08) ◽  
pp. 1279-1286
Author(s):  
Kamal K. Rajbongshi ◽  
Srinivas Ambala ◽  
Thavendran Govender ◽  
Hendrik G. Kruger ◽  
Per I. Arvidsson ◽  
...  
Keyword(s):  
Free Radical ◽  
Microwave Irradiation ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Aromatic Aldehydes ◽  
Efficient Catalyst ◽  
Radical Initiator ◽  
Catalyst Free ◽  
Broad Scope ◽  
Cross Coupling Reaction

An efficient catalyst-free radical cross-coupling reaction between aromatic aldehydes and sulfoximines was developed. The reaction took place in the presence of N-bromosuccinimide as the radical initiator under microwave irradiation to afford the corresponding acylated sulfoximines in moderate to excellent yields (27 examples). This protocol proved to be rapid, easy to handle, and applicable to a broad scope of substrates.

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