Iron-Catalyzed decarboxylative and oxidative decarbonylative cross-coupling: A new strategy for the synthesis of monofluoroalkenes

2022 ◽  
Author(s):  
Xiao-Yu Lu ◽  
Meng-Yuan Ge ◽  
Ting-Hua Tao ◽  
Xiao-Mei Sun ◽  
Meng-Ting Gao ◽  
...  
Keyword(s):  
Cross Coupling ◽  
Aliphatic Aldehydes ◽  
Practical Strategy ◽  
New Strategy

Herein, an iron(II)-catalyzed decarboxylative and oxidative decarbonylative cross-coupling of α-fluoroacrylic acids with aliphatic aldehydes is presented. This methodology provided a novel and practical strategy for the construction of the monofluoroalkenes...

Copper-catalyzed decarboxylative and oxidative decarbonylative cross-coupling between cinnamic acids and aliphatic aldehydes

2018 ◽  
Vol 5 (22) ◽  
pp. 3299-3305 ◽  
Author(s):  
Zaigang Luo ◽  
Xinxin Han ◽  
Yuyu Fang ◽  
Peng Liu ◽  
Chengtao Feng ◽  
...  
Keyword(s):  
Cross Coupling ◽  
Cinnamic Acids ◽  
Aliphatic Aldehydes

A convenient copper-catalyzed decarboxylative and oxidative decarbonylative cross-coupling of cinnamic acids with aliphatic aldehydes was achieved, which provides a useful strategy of C(sp3)–C(sp2) bonds construction for the synthesis of alkyl-substituted E-alkenes.

ChemInform Abstract: Transition-Metal-Assisted Radical/Radical Cross-Coupling: A New Strategy to the Oxidative C(sp3)-H/N-H Cross-Coupling.

ChemInform ◽  
2014 ◽  
Vol 45 (50) ◽  
pp. no-no
Author(s):  
Liangliang Zhou ◽  
Shan Tang ◽  
Xiaotian Qi ◽  
Caitao Lin ◽  
Kun Liu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Cross Coupling ◽  
New Strategy

scholarly journals Nickel-Catalyzed Reductive Coupling of Unactivated Alkyl Bromides and Aliphatic Aldehydes

2021 ◽  
Author(s):  
Cole Cruz ◽  
John Montgomery
Keyword(s):  
Functional Groups ◽  
Catalytic System ◽  
Cross Coupling ◽  
Secondary Alcohols ◽  
Reductive Coupling ◽  
Aliphatic Aldehydes ◽  
Alkyl Bromide ◽  
Alkyl Bromides ◽  
Wide Range ◽  
Ni Species

We report the development of a mild, convenient coupling of aliphatic aldehydes and unactivated alkyl bromides. The catalytic system features the use of a common Ni(II) precatalyst and a readily available bisoxazoline ligand and affords silyl-protected secondary alcohols. The reaction is operationally simple, utilizing Mn as a stoichiometric reductant, and tolerates a wide range of functional groups. Initial mechanistic experiments support a mechanism featuring an alpha-silyloxy Ni species which undergoes formal oxidative addition of the alkyl bromide species via a reductive cross-coupling pathway.

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