scholarly journals Spatially heterogeneous epidermal growth factor release from microporous annealed particle (MAP) hydrogel for improved wound closure

2021 ◽  
Author(s):  
Lauren Pruett ◽  
Regan Ellis ◽  
Meghan McDermott ◽  
Colleen Roosa ◽  
Donald Griffin
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Wound Closure ◽  
Dermal Wound Healing ◽  
Epidermal Growth ◽  
Growth Factor Release ◽  
Dermal Wound ◽  
Factor Release

We present lyophilized heparin microgels which can be directly rehydrated with epidermal growth factor and mixed with PEG microgels to form heterogenous MAP scaffolds. These EGF-releasing MAP scaffolds promote accelerated dermal wound healing.

Lysozyme-Triggered Epidermal Growth Factor Release from Bacterial Cellulose Membranes Controlled by Smart Nanostructured Films

2014 ◽  
Vol 103 (12) ◽  
pp. 3958-3965 ◽  
Author(s):  
Guilherme Fadel Picheth ◽  
Maria Rita Sierakowski ◽  
Marco Aurelio Woehl ◽  
Lucy Ono ◽  
Axel Rulf Cofré ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Bacterial Cellulose ◽  
Nanostructured Films ◽  
Epidermal Growth ◽  
Growth Factor Release ◽  
Cellulose Membranes ◽  
Factor Release

scholarly journals Film-Forming Spray of Water-Soluble Chitosan Containing Liposome-Coated Human Epidermal Growth Factor for Wound Healing

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5326
Author(s):  
Abd. Kakhar Umar ◽  
Sriwidodo Sriwidodo ◽  
Iman Permana Maksum ◽  
Nasrul Wathoni
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Wound Dressing ◽  
Wound Closure ◽  
Water Soluble ◽  
Film Forming ◽  
Epidermal Growth ◽  
Film Method ◽  
Wound Healing Activity

Human epidermal growth factor (hEGF) has been known to have excellent wound-healing activity. However, direct application to the wound area can lead to low hEGF bioavailability due to protease enzymes or endocytosis. The use of liposomes as coatings and carriers can protect hEGF from degradation by enzymes, chemical reactions, and immune reactions. Sustained release using a matrix polymer can also keep the levels of hEGF in line with the treatment. Therefore, this study aimed to develop a film-forming spray of water-soluble chitosan (FFSWSC) containing hEGF-liposomes as a potential wound dressing. The hEGF-liposomes were prepared using the hydration film method, and the preparation of the FFSWSC was achieved by the ionic gelation method. The hydration film method produced hEGF-liposomes that were round and spread with a Z-average of 219.3 nm and encapsulation efficiency of 99.87%, whereas the film-forming solution, which provided good sprayability, had a formula containing 2% WSC and 3% propylene glycol with a viscosity, spray angle, droplet size, spray weight, and occlusion factor of 21.94 ± 0.05 mPa.s, 73.03 ± 1.28°, 54.25 ± 13.33 µm, 0.14 ± 0.00 g, and 14.57 ± 3.41%, respectively. The pH, viscosity, and particle size of the FFSWSC containing hEGF-liposomes were stable during storage for a month in a climatic chamber (40 ± 2 °C, RH 75 ± 5%). A wound healing activity test on mice revealed that hEGF-liposomes in FFSWSC accelerated wound closure significantly, with a complete wound closure on day 6. Based on the findings, we concluded that FFSWSC containing hEGF-liposomes has the potential to be used as a wound dressing.

Modulation of Epidermal Growth Factor Release by Biopolymer-Coated Liposomes

2020 ◽  
Vol 109 (7) ◽  
pp. 2294-2301
Author(s):  
Gabriela Pereira Parchen ◽  
Joslaine Jacumazo ◽  
Heidegrid Siebert Koop ◽  
Stellee Marcela Petris Biscaia ◽  
Edvaldo S. Trindade ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Epidermal Growth ◽  
Growth Factor Release ◽  
Factor Release

scholarly journals Epidermal growth factor-containing wound closure enhances wound healing in non-diabetic and diabetic rats

2009 ◽  
Vol 6 (2) ◽  
pp. 107-115 ◽  
Author(s):  
S Dogan ◽  
S Demirer ◽  
I Kepenekci ◽  
B Erkek ◽  
A Kiziltay ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Wound Closure ◽  
Diabetic Rats ◽  
Epidermal Growth
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