scholarly journals Sticky swinging arm dynamics: studies of an acyl carrier protein domain from the mycolactone polyketide synthase

2016 ◽  
Vol 473 (8) ◽  
pp. 1097-1110 ◽  
Author(s):  
Steven Vance ◽  
Olga Tkachenko ◽  
Ben Thomas ◽  
Mona Bassuni ◽  
Hui Hong ◽  
...  
Keyword(s):  
Polyketide Synthase ◽  
Acyl Carrier Protein ◽  
Protein Domain ◽  
Carrier Protein ◽  
Protein Surface ◽  
Prosthetic Group ◽  
Polyketide Biosynthesis ◽  
Covalently Linked

When covalently linked to an acyl carrier protein (ACP) and loaded with acyl substrate-mimics, some 4′-phosphopantetheine prosthetic group arms swing freely, whereas others stick to the protein surface, suggesting a possible mode of interaction with enzyme domains during polyketide biosynthesis.

Solution Structure of an Acyl Carrier Protein Domain from a Fungal Type I Polyketide Synthase,

Biochemistry ◽  
2010 ◽  
Vol 49 (10) ◽  
pp. 2186-2193 ◽  
Author(s):  
Pakorn Wattana-amorn ◽  
Christopher Williams ◽  
Eliza Płoskoń ◽  
Russell J. Cox ◽  
Thomas J. Simpson ◽  
...  
Keyword(s):  
Solution Structure ◽  
Polyketide Synthase ◽  
Acyl Carrier Protein ◽  
Protein Domain ◽  
Carrier Protein ◽  
Type I

scholarly journals Solution Structures of the Acyl Carrier Protein Domain from the Highly Reducing Type I Iterative Polyketide Synthase CalE8

PLoS ONE ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. e20549 ◽  
Author(s):  
Jackwee Lim ◽  
Rong Kong ◽  
Elavazhagan Murugan ◽  
Chun Loong Ho ◽  
Zhao-Xun Liang ◽  
...  
Keyword(s):  
Polyketide Synthase ◽  
Acyl Carrier Protein ◽  
Protein Domain ◽  
Carrier Protein ◽  
Type I ◽  
Solution Structures ◽  
Iterative Polyketide Synthase

scholarly journals Dissecting how modular polyketide synthase ketoreductases interact with acyl carrier protein-attached substrates

2017 ◽  
Vol 53 (83) ◽  
pp. 11457-11460 ◽  
Author(s):  
Luisa Moretto ◽  
Steven Vance ◽  
Brennan Heames ◽  
R. William Broadhurst
Keyword(s):  
Binding Site ◽  
Active Site ◽  
Polyketide Synthase ◽  
Acyl Carrier Protein ◽  
Carrier Protein ◽  
Prosthetic Group ◽  
Correct Orientation ◽  
Interaction Studies ◽  
Modular Polyketide Synthase

Interaction studies show that KR domains possess a generic binding site for ACP domains and provide evidence that the 5′-phosphopantetheine prosthetic group plays a key role in delivering acyl substrates to the active site in the correct orientation.

scholarly journals Solution structure and proposed domain-domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase

2007 ◽  
Vol 16 (10) ◽  
pp. 2093-2107 ◽  
Author(s):  
Viktor Y. Alekseyev ◽  
Corey W. Liu ◽  
David E. Cane ◽  
Joseph D. Puglisi ◽  
Chaitan Khosla
Keyword(s):  
Solution Structure ◽  
Polyketide Synthase ◽  
Acyl Carrier Protein ◽  
Protein Domain ◽  
Carrier Protein ◽  
Modular Polyketide Synthase

scholarly journals De Novo Design and Implementation of a Tandem Acyl Carrier Protein Domain in a Type I Modular Polyketide Synthase

2018 ◽  
Vol 13 (11) ◽  
pp. 3072-3077 ◽  
Author(s):  
Zilong Wang ◽  
Saket R. Bagde ◽  
Gerardo Zavala ◽  
Tsutomu Matsui ◽  
Xi Chen ◽  
...  
Keyword(s):  
Polyketide Synthase ◽  
De Novo ◽  
Acyl Carrier Protein ◽  
De Novo Design ◽  
Protein Domain ◽  
Carrier Protein ◽  
Type I ◽  
Design And Implementation ◽  
Modular Polyketide Synthase

Structural Basis of Acyl-Carrier Protein Interactions in Fatty Acid and Polyketide Biosynthesis

2020 ◽  
pp. 61-122 ◽  
Author(s):  
Jeffrey T. Mindrebo ◽  
Ashay Patel ◽  
Laëtitia E. Misson ◽  
Woojoo E. Kim ◽  
Tony D. Davis ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Protein Interactions ◽  
Acyl Carrier Protein ◽  
Structural Basis ◽  
Carrier Protein ◽  
Polyketide Biosynthesis
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