Effects of glucosamine hydrochloride and chondroitin sulphate, alone and in combination, on normal and interleukin-1 conditioned equine articular cartilage explant metabolism

2010 ◽  
Vol 37 (3) ◽  
pp. 227-231 ◽  
Author(s):  
J. E. DECHANT ◽  
G. M. BAXTER ◽  
D. D. FRISBIE ◽  
G. W. TROTTER ◽  
C. W. McILWRAITH
Keyword(s):  
Articular Cartilage ◽  
Chondroitin Sulphate ◽  
Interleukin 1 ◽  
Glucosamine Hydrochloride ◽  
Cartilage Explant

Effects of Interleukin-1 and Anti-Inflammatory Drugs on the Degradation of Human Articular Cartilage

Drugs ◽  
1988 ◽  
Vol 35 (Supplement 1) ◽  
pp. 33-41 ◽  
Author(s):  
M. Shinmei ◽  
T. Kikuchi ◽  
K. Masuda ◽  
Y. Shimomura
Keyword(s):  
Articular Cartilage ◽  
Interleukin 1 ◽  
Human Articular Cartilage ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

MODULATION OF ENDOGENOUS OSTEOGENIC PROTEIN-1 (OP-1) BY INTERLEUKIN-1 IN ADULT HUMAN ARTICULAR CARTILAGE

2003 ◽  
Vol 85 ◽  
pp. 67-74 ◽  
Author(s):  
CHARIS MERRIHEW ◽  
STEPHAN SOEDER ◽  
DAVID C. RUEGER ◽  
KLAUS E. KUETTNER ◽  
SUSAN CHUBINSKAYA
Keyword(s):  
Articular Cartilage ◽  
Interleukin 1 ◽  
Human Articular Cartilage ◽  
Adult Human ◽  
Osteogenic Protein

scholarly journals Interaction of strain and interleukin-1 in articular cartilage: effects on proteoglycan synthesis in chondrocytes

2000 ◽  
Vol 29 (5) ◽  
pp. 389-394 ◽  
Author(s):  
Robert J. Gassner ◽  
Michael J. Buckley ◽  
Rebecca K. Studer ◽  
Chris H. Evans ◽  
Sudha Agarwal
Keyword(s):  
Articular Cartilage ◽  
Interleukin 1 ◽  
Proteoglycan Synthesis

scholarly journals Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein

1984 ◽  
Vol 224 (2) ◽  
pp. 461-466 ◽  
Author(s):  
J Saklatvala ◽  
L M C Pilsworth ◽  
S J Sarsfield ◽  
J Gavrilovic ◽  
J K Heath
Keyword(s):  
Articular Cartilage ◽  
Prostaglandin E2 ◽  
Interleukin 1 ◽  
Thymocyte Proliferation

Homogeneous catabolin from pig leucocytes induced proteoglycan breakdown, but not collagen breakdown, in explants of articular cartilage. It augmented lectin-induced proliferation of mouse thymocytes, stimulated production of prostaglandin E2 and collagenase by fibroblasts and chondrocytes, and increased Ca2+ release from mouse calvarial explants, all at concentrations down to 50 pM. In view of these effects it was concluded that pig catabolin is a form of interleukin 1.

scholarly journals Influence of Intra-Articular Administration of Trichostatin A on Autologous Osteochondral Transplantation in a Rabbit Model

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Huacheng Hou ◽  
Ke Zheng ◽  
Guanghu Wang ◽  
Shiro Ikegawa ◽  
Minghao Zheng ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Cartilage Repair ◽  
Trichostatin A ◽  
Interleukin 1 ◽  
Rabbit Model ◽  
Treated Group ◽  
Control Group ◽  
Osteochondral Transplantation ◽  
Autologous Osteochondral Transplantation ◽  
Significant Difference

Autologous osteochondral transplantation (AOT) is a method for articular cartilage repair. However, several disadvantages of this method have been reported, such as transplanted cartilage degeneration and the lack of a connection between the grafted and adjacent cartilage tissues. To evaluate the effect of intra-articular administration of trichostatin A (TSA) on AOT, we conducted a case control study in a rabbit model. International Cartilage Repair Society (ICRS) macroscopic scores, the modified O’Driscoll histology scores, and real-time PCR were utilized to evaluate the results. At 4 weeks, both macroscopic and histological assessments showed that there was no significant difference between the TSA and control groups. However, the mean macroscopic and histological scores for the TSA-treated group were significantly higher than the scores for the control group at 12 weeks. TSA was shown to directly reduce collagen type II (COL2), aggrecan, matrix metalloproteinase (MMP), and a disintegrin and metalloproteinase domain with thrombospondin motifs 5 (ADAMTS-5) expression and to simultaneously repress the upregulation of MMP-3, MMP-9, and MMP-13 levels induced by interleukin 1β(IL-1β) in chondrocytes. In conclusion, TSA protects AOT grafts from degeneration, which may provide a benefit in the repair of articular cartilage injury.

scholarly journals Activation of Interleukin-1 Signaling Cascades in Normal and Osteoarthritic Articular Cartilage

2007 ◽  
Vol 171 (3) ◽  
pp. 938-946 ◽  
Author(s):  
Zhiyong Fan ◽  
Stephan Söder ◽  
Stephan Oehler ◽  
Katrin Fundel ◽  
Thomas Aigner
Keyword(s):  
Articular Cartilage ◽  
Interleukin 1 ◽  
Signaling Cascades
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