scholarly journals Identification of miR-200a as a novel suppressor of connexin 43 in breast cancer cells

2015 ◽  
Vol 35 (5) ◽  
Author(s):  
Jia Ming ◽  
Yan Zhou ◽  
Junze Du ◽  
Shenghao Fan ◽  
Beibei Pan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Connexin 43 ◽  
Breast Cancer Cells ◽  
Metastatic Breast ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Cx43 Expression

We demonstrated that miRNA (miR)-200a inhibited connexin 43 (Cx43) expression by directly targeting at the 3’-UTR of Cx43 gene in human breast cancer cells. The miR-200a/Cx43 axis might be a useful diagnostic and therapeutic target of metastatic breast cancer.

scholarly journals miR-381 suppresses C/EBPα-dependent Cx43 expression in breast cancer cells

2015 ◽  
Vol 35 (6) ◽  
Author(s):  
Jia Ming ◽  
Yan Zhou ◽  
Junze Du ◽  
Shenghao Fan ◽  
Beibei Pan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Metastatic Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Metastatic Breast ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Cx43 Expression

miR-381 suppressed CX43 expression by directly targeting the 3′-UTR of C/EBPα, a novel transcription factor of Cx43 in human breast cancer cells. The miR-381–Cx43 axis might be a useful diagnostic and therapeutic target of metastatic breast cancer.

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