Regulation by Insulin and Free Fatty Acids of Pyruvate Dehydrogenase Activity in Perfused Rat Liver

1977 ◽  
Vol 5 (4) ◽  
pp. 1000-1001 ◽  
Author(s):  
DAVID L. TOPPING ◽  
M. ANWAR GOHEER ◽  
HALDANE G. COORE ◽  
PETER A. MAYES
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Dehydrogenase Activity ◽  
Rat Liver ◽  
Pyruvate Dehydrogenase ◽  
Perfused Rat Liver

Effects of free fatty acids on carbohydrate metabolism and insulin signalling in perfused rat liver

2007 ◽  
Vol 37 (10) ◽  
pp. 774-782 ◽  
Author(s):  
C. Anderwald ◽  
B. Brunmair ◽  
K. Stadlbauer ◽  
M. Krebs ◽  
C. Fürnsinn ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Carbohydrate Metabolism ◽  
Rat Liver ◽  
Insulin Signalling ◽  
Perfused Rat Liver

Effect of thyroxine treatment on exogenous myocardial lactate oxidation

1982 ◽  
Vol 243 (5) ◽  
pp. H722-H728
Author(s):  
M. Fintel ◽  
A. H. Burns
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Dehydrogenase Activity ◽  
Pyruvate Dehydrogenase ◽  
Acid Oxidation ◽  
Lactate Oxidation ◽  
Thyroxine Treatment ◽  
Heart Preparation ◽  
Mitochondrial Oxidation ◽  
Working Rat Heart

The effect of thyroxine treatment on myocardial lactate oxidation was examined by use of an isolated, working rat heart preparation. Thyroxine treatment, both acute and chronic, was associated with a decrease in lactate oxidation, when the heart was perfused with a physiological blend of substrates (free fatty acids, lactate, and glucose). This decrease in lactate oxidation was not caused by a generalized impairment in mitochondrial oxidation of acetyl coenzyme A (CoA), as oxygen consumption was normal and fatty acid oxidation was elevated in the treated animals. The block in lactate oxidation was localized to the conversion of pyruvate to acetyl CoA, as indicated by the depressed oxidation of pyruvate and lactate. Thyroxine treatment was associated with a decrease in pyruvate dehydrogenase activity. The decrease in pyruvate dehydrogenase activity was reversible and was attributed to the enhanced myocardial oxidation of free fatty acids.

The Effect of Fatty Acids on the Regulation of Pyruvate Dehydrogenase in Perfused Rat Liver

1978 ◽  
Vol 86 (2) ◽  
pp. 519-530 ◽  
Author(s):  
Roland SCHOLZ ◽  
Merle S. OLSON ◽  
Andreas J. SCHWAB ◽  
Ursula SCHWABE ◽  
Christiane NOELL ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Rat Liver ◽  
Pyruvate Dehydrogenase ◽  
Perfused Rat Liver
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