Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination

2007 ◽  
Vol 35 (6) ◽  
pp. 1501-1503 ◽  
Author(s):  
J. Wales ◽  
E. Andreakos ◽  
M. Feldmann ◽  
B. Foxwell
Keyword(s):  
Immune Response ◽  
Pattern Recognition ◽  
Systemic Toxicity ◽  
Pattern Recognition Receptor ◽  
Intracellular Signalling ◽  
Present Review ◽  
Signalling Molecules ◽  
Receptor Signalling ◽  
Intracellular Mediators ◽  
Recognition Receptor

PRR (pattern-recognition receptor) signalling is involved early in the immune response and therefore would be attractive to target during vaccination. The use of PRR ligands has shown some success; however, toxicity and non-specificity are issues with this strategy. The targeting of PRR intracellular signalling networks would allow for greater specificity and reduced systemic toxicity. The present review examines the successes seen with overexpression or repression of PRR signalling molecules.

scholarly journals Peptidomimetic 1-Benzyl-5-methyl-4-(n-octylamino)pyrimidin-2(1H)-one Showed Cardioprotection Effect in a Myocardial Ischemia (MI) Mouse Model

Proceedings ◽  
2019 ◽  
Vol 22 (1) ◽  
pp. 72
Author(s):  
Lena Trifonov ◽  
Vadim Nudelman ◽  
Michael Zhenin ◽  
Guy Cohen ◽  
Krzysztof Jozwiak ◽  
...  
Keyword(s):  
Immune Response ◽  
Pattern Recognition ◽  
Myocardial Ischemia ◽  
Mouse Model ◽  
Innate Immune Response ◽  
Pattern Recognition Receptor ◽  
Innate Immune ◽  
Microbial Pathogens ◽  
Toll Like Receptors ◽  
Recognition Receptor

TLR4, a member of the toll-like receptors (TLRs) family, serves as a pattern recognition receptor in the innate immune response to different microbial pathogens. [...]

scholarly journals Immunobiotic Bifidobacteria Strains Modulate Rotavirus Immune Response in Porcine Intestinal Epitheliocytes via Pattern Recognition Receptor Signaling

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0152416 ◽  
Author(s):  
Takamasa Ishizuka ◽  
Paulraj Kanmani ◽  
Hisakazu Kobayashi ◽  
Ayako Miyazaki ◽  
Junichi Soma ◽  
...  
Keyword(s):  
Immune Response ◽  
Pattern Recognition ◽  
Pattern Recognition Receptor ◽  
Receptor Signaling ◽  
Recognition Receptor

CfLGBP, a pattern recognition receptor in Chlamys farreri involved in the immune response against various bacteria

2010 ◽  
Vol 29 (5) ◽  
pp. 825-831 ◽  
Author(s):  
Jialong Yang ◽  
Limei Qiu ◽  
Lingling Wang ◽  
Xiumei Wei ◽  
Huan Zhang ◽  
...  
Keyword(s):  
Immune Response ◽  
Pattern Recognition ◽  
Chlamys Farreri ◽  
Pattern Recognition Receptor ◽  
Recognition Receptor
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