Regulation of SNAP-25 trafficking and function by palmitoylation
2010 ◽
Vol 38
(1)
◽
pp. 163-166
◽
Keyword(s):
The SNARE (soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptor) protein SNAP-25 (25 kDa synaptosome-associated protein) is essential for regulated exocytosis in neuronal and neuroendocrine cells. Whereas the majority of SNARE proteins contain transmembrane domains, SNAP-25 is instead anchored to membranes by the palmitoylation of a central cysteine-rich region. In this review, we discuss the mechanisms of SNAP-25 palmitoylation and how this modification regulates the intracellular trafficking and exocytotic function of this essential protein.
2013 ◽
Vol 36
(9)
◽
pp. 1500-1502
◽
Keyword(s):
2016 ◽
Vol 11
(1)
◽
pp. 74-93
◽
Keyword(s):
2001 ◽
Vol 276
(31)
◽
pp. 29456-29465
◽
Keyword(s):
1997 ◽
Vol 272
(44)
◽
pp. 28036-28041
◽
Keyword(s):
2010 ◽
Vol 188
(4)
◽
pp. 537-546
◽
Keyword(s):
2012 ◽
Vol 92
(4)
◽
pp. 1915-1964
◽