Viruses and the human DEAD-box helicase DDX3: inhibition or exploitation?

2011 ◽  
Vol 39 (2) ◽  
pp. 679-683 ◽  
Author(s):  
Martina Schröder
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Global Health ◽  
Antiviral Immunity ◽  
Rna Helicase ◽  
Dead Box ◽  
Health Threats ◽  
Prime Target

Human DDX3 is a DEAD (Asp-Glu-Ala-Asp)-box RNA helicase that appears to be a prime target for viral manipulation. While two viruses that manifest major global health threats, HIV and HCV (hepatitis C virus), utilize DDX3 for their replication, other viruses inhibit DDX3's newly identified function in innate antiviral signalling. This review discusses the role of DDX3 in antiviral immunity and its inhibition or exploitation by different viruses.

scholarly journals Cellular DEAD-box RNA helicase DDX6 modulates interaction of miR-122 with the 5′ untranslated region of hepatitis C virus RNA

Virology ◽  
2017 ◽  
Vol 507 ◽  
pp. 231-241 ◽  
Author(s):  
Jason M. Biegel ◽  
Eric Henderson ◽  
Erica M. Cox ◽  
Gaston Bonenfant ◽  
Rachel Netzband ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Untranslated Region ◽  
Rna Helicase ◽  
Hepatitis C Virus Rna ◽  
Dead Box ◽  
Virus Rna

scholarly journals Role of the DExH Motif of the Japanese Encephalitis Virus and Hepatitis C Virus NS3 Proteins in the ATPase and RNA Helicase Activities

Virology ◽  
2000 ◽  
Vol 273 (2) ◽  
pp. 316-324 ◽  
Author(s):  
Andi Utama ◽  
Hiroyuki Shimizu ◽  
Futoshi Hasebe ◽  
Kouichi Morita ◽  
Akira Igarashi ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Rna Helicase ◽  
Encephalitis Virus

scholarly journals DDX3 DEAD-Box RNA Helicase Is Required for Hepatitis C Virus RNA Replication

2007 ◽  
Vol 81 (24) ◽  
pp. 13922-13926 ◽  
Author(s):  
Yasuo Ariumi ◽  
Misao Kuroki ◽  
Ken-ichi Abe ◽  
Hiromichi Dansako ◽  
Masanori Ikeda ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Rna Replication ◽  
Rna Helicase ◽  
Hcv Rna ◽  
Dead Box ◽  
Hcv Core Protein ◽  
Virus Rna ◽  
Culture Supernatants

ABSTRACT DDX3, a DEAD-box RNA helicase, binds to the hepatitis C virus (HCV) core protein. However, the role(s) of DDX3 in HCV replication is still not understood. Here we demonstrate that the accumulation of both genome-length HCV RNA (HCV-O, genotype 1b) and its replicon RNA were significantly suppressed in HuH-7-derived cells expressing short hairpin RNA targeted to DDX3 by lentivirus vector transduction. As well, RNA replication of JFH1 (genotype 2a) and release of the core into the culture supernatants were suppressed in DDX3 knockdown cells after inoculation of the cell culture-generated HCVcc. Thus, DDX3 is required for HCV RNA replication.

scholarly journals Hepatitis C Virus Core Protein Binds to a DEAD Box RNA Helicase

1999 ◽  
Vol 274 (22) ◽  
pp. 15751-15756 ◽  
Author(s):  
Naoto Mamiya ◽  
Howard J. Worman
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Rna Helicase ◽  
Dead Box ◽  
Virus Core

Role of autophagy in hepatitis C virus replication

2019 ◽  
Author(s):  
WI Twu ◽  
K Tabata ◽  
D Paul ◽  
R Bartenschlager
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Replication

Role of Hepatitis C Virus Core Antigen Assay in Blood Donors Screening at Zagazig University Hospitals

2018 ◽  
Vol 8 (1) ◽  
pp. 48-54
Author(s):  
Rashed Hassan ◽  
Abdelmonem Elshamy ◽  
Sameh Abdel Monem ◽  
Emad Moustafa ◽  
Essam Wahab
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Blood Donors ◽  
Core Antigen ◽  
University Hospitals ◽  
Virus Core ◽  
Antigen Assay
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