The Molecular Biology of Inflammatory Bowel Diseases

2011 ◽  
Vol 39 (4) ◽  
pp. 1057-1060 ◽  
Author(s):  
Anthony P. Corfield ◽  
Heather M. Wallace ◽  
Chris S.J. Probert
Keyword(s):  
Gastrointestinal Tract ◽  
Animal Models ◽  
Molecular Biology ◽  
Inflammatory Bowel Diseases ◽  
Susceptibility Genes ◽  
Adaptive Responses ◽  
Molecular Features ◽  
Disease Mechanisms ◽  
Bowel Diseases ◽  
Inflammatory Bowel

IBDs (inflammatory bowel diseases) are a group of diseases affecting the gastrointestinal tract. The diseases are multifactorial and cover genetic aspects: susceptibility genes, innate and adaptive responses to inflammation, and structure and efficacy of the mucosal protective barrier. Animal models of IBD have been developed to gain further knowledge of the disease mechanisms. These topics form an overlapping background to enable an improved understanding of the molecular features of these diseases. A series of articles is presented based on the topics covered at the Biochemical Society Focused Meeting The Molecular Biology of Inflammatory Bowel Diseases.

Vitamin A and inflammatory bowel diseases: from cellular studies and animal models to human disease

2018 ◽  
Vol 13 (1) ◽  
pp. 25-35 ◽  
Author(s):  
Sandra Maria Barbalho ◽  
Ricardo de Alvares Goulart ◽  
Gabriela Lombardi dos Santos Almeid Batista
Keyword(s):  
Animal Models ◽  
Vitamin A ◽  
Inflammatory Bowel Diseases ◽  
Human Disease ◽  
Bowel Diseases ◽  
Inflammatory Bowel

scholarly journals Glucocorticosteroid therapy in inflammatory bowel diseases: From clinical practice to molecular biology

2017 ◽  
Vol 23 (36) ◽  
pp. 6628-6638 ◽  
Author(s):  
Karen Dubois-Camacho ◽  
Payton A Ottum ◽  
Daniel Franco-Muñoz ◽  
Marjorie De la Fuente ◽  
Alejandro Torres-Riquelme ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Molecular Biology ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel

scholarly journals Animal models for inducing inflammatory bowel diseases: integrative review

2021 ◽  
Vol 11 (1) ◽  
pp. 80-87
Author(s):  
Nadja Maria da Costa Melo ◽  
Marília Virgo Silva Almeida ◽  
Daniel Melo de Oliveira Campos ◽  
Claudio Bruno Silva de Oliveira ◽  
Jonas Ivan Nobre Oliveira
Keyword(s):  
Acetic Acid ◽  
Animal Models ◽  
Inflammatory Bowel Diseases ◽  
Intestinal Inflammation ◽  
Integrative Review ◽  
Chemical Models ◽  
Experimental Induction ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Colitis Model

Objective: To identify and describe comparatively the chemical models of the induction of inflammatory bowel diseases (IBD) in rodents most used and that best mimic the pathogenesis in humans. Methods: Based on an integrative review in the MEDLINE and LILACS databases, it was investigated which experimental induction models were most cited in articles published from 2004 to 2020, with the descriptors "Colitis/CI", "Colitis model ulcerative" and "Intestinal inflammation model." All empirical articles that addressed one or more inflammation models in rats or mice were included. Results: 239 articles were identified; of these, only ten empirical articles were selected. The most used models were colitis induced by TNBS acid, DSS, and colitis induced by acetic acid (AA). Conclusion: It was possible to identify the most used models to promote the induction of intestinal inflammation in rats, and both models proved to be effective according to the limitations observed in the models described, suggesting the need for new works that use more well-defined protocols and that more fully represent the pathophysiological complexity of the disease.

scholarly journals Going Viral: a Novel Role for Bacteriophage in Colorectal Cancer

mBio ◽  
2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Scott A. Handley ◽  
Suzanne Devkota
Keyword(s):  
Colorectal Cancer ◽  
Dark Matter ◽  
Gastrointestinal Tract ◽  
Sample Preparation ◽  
Cross Section ◽  
Inflammatory Bowel Diseases ◽  
Healthy Controls ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Disease Signatures

ABSTRACT Microbiome-based signatures of disease have focused primarily on the bacterial component of the microbiome for numerous reasons, including ease of sample preparation and depth of the curated bacterial database. However, even more numerous than bacteria are the bacteriophages of the viral portion of the microbiome, which have emerged with identifiable disease signatures in other diseases, such as inflammatory bowel diseases. Here, G. D. Hannigan, M. B. Duhaime, M. T. Ruffin, IV, C. C. Koumpouras, and P. D. Schloss (mBio 9:e02248-18, https://doi.org/10.1128/mBio.02248-18) present a study that explores the potential bacteriophage signatures in patients with colorectal cancer (CRC) and the associated changes in bacterial signatures. Sampling from a cross section of 60 patients at different stages of CRC in addition to 30 healthy controls, this study highlights the need for greater exploration into the virome, including the “dark matter” of diverse forms that viruses assume in the gastrointestinal tract.

Accurate and rapid microfluidic ELISA to monitor Infliximab titers in patients with inflammatory bowel diseases

The Analyst ◽  
2022 ◽  
Author(s):  
Inês Iria ◽  
Ruben R.G. Soares ◽  
Eduardo Brás ◽  
Virginia Chu ◽  
João Gonçalves ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Gastrointestinal Tract ◽  
Chronic Inflammation ◽  
Inflammatory Bowel Diseases ◽  
Bowel Disease ◽  
Biological Therapy ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Inflammatory bowel disease (IBD) is a term used to describe disorders that involve chronic inflammation in the gastrointestinal tract, affecting more than 6.8 million people worldwide.1 Biological therapy is used...

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