scholarly journals Going Viral: a Novel Role for Bacteriophage in Colorectal Cancer

mBio ◽  
2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Scott A. Handley ◽  
Suzanne Devkota
Keyword(s):  
Colorectal Cancer ◽  
Dark Matter ◽  
Gastrointestinal Tract ◽  
Sample Preparation ◽  
Cross Section ◽  
Inflammatory Bowel Diseases ◽  
Healthy Controls ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Disease Signatures

ABSTRACT Microbiome-based signatures of disease have focused primarily on the bacterial component of the microbiome for numerous reasons, including ease of sample preparation and depth of the curated bacterial database. However, even more numerous than bacteria are the bacteriophages of the viral portion of the microbiome, which have emerged with identifiable disease signatures in other diseases, such as inflammatory bowel diseases. Here, G. D. Hannigan, M. B. Duhaime, M. T. Ruffin, IV, C. C. Koumpouras, and P. D. Schloss (mBio 9:e02248-18, https://doi.org/10.1128/mBio.02248-18) present a study that explores the potential bacteriophage signatures in patients with colorectal cancer (CRC) and the associated changes in bacterial signatures. Sampling from a cross section of 60 patients at different stages of CRC in addition to 30 healthy controls, this study highlights the need for greater exploration into the virome, including the “dark matter” of diverse forms that viruses assume in the gastrointestinal tract.

scholarly journals Are Volatile Organic Compounds Accurate Markers in the Assessment of Colorectal Cancer and Inflammatory Bowel Diseases? A Review

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2361
Author(s):  
Filippo Vernia ◽  
Marco Valvano ◽  
Stefano Fabiani ◽  
Gianpiero Stefanelli ◽  
Salvatore Longo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Inflammatory Bowel Diseases ◽  
Screening Programs ◽  
Inflammatory Status ◽  
Incidence And Mortality ◽  
Volatile Organic ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the Western world. Early detection decreases incidence and mortality. Screening programs based on fecal occult blood testing help identify patients requiring endoscopic examination, but accuracy is far from optimal. Among the alternative strategies, volatile organic compounds (VOCs) represent novel potentially useful biomarkers of colorectal cancer. They also represent a promising tool for the screening of both intestinal inflammation and related CRC. The review is focused on the diagnostic potential of VOCs in sporadic CRC and in inflammatory bowel diseases (IBD), which increase the risk of CRC, analyzing future clinical applications. Despite limitations related to inadequate strength of evidence, differing analytical platforms identify different VOCs, and this unconventional approach for diagnosing colorectal cancer is promising. Some VOC profiles, besides identifying inflammation, seem disease-specific in inflammatory bowel diseases. Thus, breath, urine, and fecal VOCs provide a new and promising clinical approach to differential diagnosis, evaluation of the inflammatory status, and possibly the assessment of treatment efficacy in IBD. Conversely, specific VOC patterns correlating inflammatory bowel disease and cancer risk are still lacking, and studies focused on this issue are strongly encouraged. No prospective studies have assessed the risk of CRC development by using VOCs in samples collected before the onset of disease, both in the general population and in patients with IBD.

Risk of colorectal cancer in inflammatory bowel diseases

2020 ◽  
Vol 64 ◽  
pp. 51-60 ◽  
Author(s):  
Muhammad Shahid Nadeem ◽  
Vikas Kumar ◽  
Fahad A. Al-Abbasi ◽  
Mohammad Amjad Kamal ◽  
Firoz Anwar
Keyword(s):  
Colorectal Cancer ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Endoscopic surveillance of colorectal cancer in inflammatory bowel diseases: a review of the literature

2020 ◽  
Vol 20 (10) ◽  
pp. 851-863
Author(s):  
Alessandro Vitello ◽  
Endrit Shahini ◽  
Fabio S. Macaluso ◽  
Gaetano C. Morreale ◽  
Emanuele Sinagra ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Inflammatory Bowel Diseases ◽  
Endoscopic Surveillance ◽  
Review Of The Literature ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Accurate and rapid microfluidic ELISA to monitor Infliximab titers in patients with inflammatory bowel diseases

The Analyst ◽  
2022 ◽  
Author(s):  
Inês Iria ◽  
Ruben R.G. Soares ◽  
Eduardo Brás ◽  
Virginia Chu ◽  
João Gonçalves ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Gastrointestinal Tract ◽  
Chronic Inflammation ◽  
Inflammatory Bowel Diseases ◽  
Bowel Disease ◽  
Biological Therapy ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Inflammatory bowel disease (IBD) is a term used to describe disorders that involve chronic inflammation in the gastrointestinal tract, affecting more than 6.8 million people worldwide.1 Biological therapy is used...

The risk of colorectal cancer in patients with inflammatory bowel diseases in Finland: A follow-up of 20years

2013 ◽  
Vol 7 (11) ◽  
pp. e551-e557 ◽  
Author(s):  
Pia Manninen ◽  
Anna-Liisa Karvonen ◽  
Heini Huhtala ◽  
Petri Aitola ◽  
Marja Hyöty ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel
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