Animal Models for Human Inflammatory Bowel Diseases

1982 ◽  
pp. 126-134 ◽  
Author(s):  
Andrew B. Onderdonk
Keyword(s):  
Animal Models ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Vitamin A and inflammatory bowel diseases: from cellular studies and animal models to human disease

2018 ◽  
Vol 13 (1) ◽  
pp. 25-35 ◽  
Author(s):  
Sandra Maria Barbalho ◽  
Ricardo de Alvares Goulart ◽  
Gabriela Lombardi dos Santos Almeid Batista
Keyword(s):  
Animal Models ◽  
Vitamin A ◽  
Inflammatory Bowel Diseases ◽  
Human Disease ◽  
Bowel Diseases ◽  
Inflammatory Bowel

scholarly journals Animal models for inducing inflammatory bowel diseases: integrative review

2021 ◽  
Vol 11 (1) ◽  
pp. 80-87
Author(s):  
Nadja Maria da Costa Melo ◽  
Marília Virgo Silva Almeida ◽  
Daniel Melo de Oliveira Campos ◽  
Claudio Bruno Silva de Oliveira ◽  
Jonas Ivan Nobre Oliveira
Keyword(s):  
Acetic Acid ◽  
Animal Models ◽  
Inflammatory Bowel Diseases ◽  
Intestinal Inflammation ◽  
Integrative Review ◽  
Chemical Models ◽  
Experimental Induction ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Colitis Model

Objective: To identify and describe comparatively the chemical models of the induction of inflammatory bowel diseases (IBD) in rodents most used and that best mimic the pathogenesis in humans. Methods: Based on an integrative review in the MEDLINE and LILACS databases, it was investigated which experimental induction models were most cited in articles published from 2004 to 2020, with the descriptors "Colitis/CI", "Colitis model ulcerative" and "Intestinal inflammation model." All empirical articles that addressed one or more inflammation models in rats or mice were included. Results: 239 articles were identified; of these, only ten empirical articles were selected. The most used models were colitis induced by TNBS acid, DSS, and colitis induced by acetic acid (AA). Conclusion: It was possible to identify the most used models to promote the induction of intestinal inflammation in rats, and both models proved to be effective according to the limitations observed in the models described, suggesting the need for new works that use more well-defined protocols and that more fully represent the pathophysiological complexity of the disease.

The Molecular Biology of Inflammatory Bowel Diseases

2011 ◽  
Vol 39 (4) ◽  
pp. 1057-1060 ◽  
Author(s):  
Anthony P. Corfield ◽  
Heather M. Wallace ◽  
Chris S.J. Probert
Keyword(s):  
Gastrointestinal Tract ◽  
Animal Models ◽  
Molecular Biology ◽  
Inflammatory Bowel Diseases ◽  
Susceptibility Genes ◽  
Adaptive Responses ◽  
Molecular Features ◽  
Disease Mechanisms ◽  
Bowel Diseases ◽  
Inflammatory Bowel

IBDs (inflammatory bowel diseases) are a group of diseases affecting the gastrointestinal tract. The diseases are multifactorial and cover genetic aspects: susceptibility genes, innate and adaptive responses to inflammation, and structure and efficacy of the mucosal protective barrier. Animal models of IBD have been developed to gain further knowledge of the disease mechanisms. These topics form an overlapping background to enable an improved understanding of the molecular features of these diseases. A series of articles is presented based on the topics covered at the Biochemical Society Focused Meeting The Molecular Biology of Inflammatory Bowel Diseases.

The value of experimental models of colitis in predicting efficacy of biological therapies for inflammatory bowel diseases

2013 ◽  
Vol 305 (11) ◽  
pp. G763-G785 ◽  
Author(s):  
Vassilis Valatas ◽  
Michael Vakas ◽  
George Kolios
Keyword(s):  
Animal Models ◽  
Inflammatory Bowel Diseases ◽  
Inflammatory Diseases ◽  
Experimental Models ◽  
Biological Therapies ◽  
Disease Pathogenesis ◽  
Preclinical Data ◽  
Bowel Diseases ◽  
Inflammatory Bowel

During the last decade, biological therapies have an increasing share in the modern therapeutics of various diseases including inflammatory bowel diseases (IBD). Animal models of IBD have often been used to identify the targets of biological therapies, to test their relevance to disease pathogenesis, to assess their therapeutic efficacy in vivo, and to check for drug toxicity. In the field of inflammatory diseases the majority of biologics under development have failed to reach the clinic. This review examines the ability of preclinical data from animal models of IBD to predict success or failure of biologics in human IBD. Specifically, it describes the murine models of IBD, the mechanism of disease induction, the phenotype of the disease, its relevance to human IBD, and the specific immunological features of disease pathogenesis in each model and mainly compares the results of the phase II and III trials of biologics in IBD with preclinical data obtained from studies in animal models. Finally, it examines the possible reasons for low success in translation from bench to bedside and offers some suggestions to improve translation rates.

scholarly journals Host–microbe interactions in the gut: lessons learned from models of inflammatory bowel diseases

2014 ◽  
Vol 1 (2) ◽  
pp. 61-76
Author(s):  
Eytan Wine
Keyword(s):  
Immune System ◽  
Animal Models ◽  
Patient Care ◽  
Inflammatory Bowel Diseases ◽  
Gut Microbes ◽  
Bowel Diseases ◽  
Microbe Interactions ◽  
Inflammatory Bowel ◽  
Host Microbe Interactions

The mammalian gut is the richest immune organ in the body and serves as a central location for immune system development, processing, and education. Inflammatory bowel diseases (IBD) provide excellent models for studying both innate and adaptive responses to gut microbes and the host-immune system – microbe interactions in the gut. Microbes are linked to almost all of the known disease-associated genetic polymorphisms in IBD and are critical mediators of environmental effects (through food, hygiene, and infection). Human and animal-based research supports the central role of microbes in IBD pathogenesis at multiple levels. Animal models of IBD only develop in the presence of microbes, and co-housing mice that are genetically susceptible to gut inflammation with normal mice can lead to the development of bowel injury. Recent advances in research technologies, such as deep-sequencing that enables detailed compositional analyses, have revolutionized the study of host–microbe interactions in the gut; however, knowing which bacteria are present in the bowel is likely not sufficient. The function of the microbiota as a community is recognized as a critical factor for gut homeostasis. Animal models of IBD have provided critical insight into basic biology and disease pathogenesis, especially regarding the role of microbes in IBD pathogenesis. Although many of these recent discoveries on host–microbe interactions are not yet applied to patient care, these basic observations will certainly revolutionize patient care in the future. Using such data, we may be able to predict risk of disease, define biological subtypes, establish tools for prevention, and even cure IBD using microbes or their products. A broad spectrum of therapeutic tools spanning from fecal transplantation, probiotics, prebiotics, and microbial products to microbe-tailored diets may supplement current IBD treatments.

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