Role of family D ATP-binding cassette transporters (ABCD) in cancer

2015 ◽  
Vol 43 (5) ◽  
pp. 937-942 ◽  
Author(s):  
Viktor Hlaváč ◽  
Pavel Souček
Keyword(s):  
Atp Binding ◽  
Long Chain Fatty Acids ◽  
Peroxisomal Disorders ◽  
Differentiated Cells ◽  
The Family ◽  
Abcd1 Gene ◽  
Available Information ◽  
Coenzyme A Esters ◽  
Atp Binding Cassette

ATP-binding cassette (ABC) transporters, belonging to the family D, are expressed in peroxisomes, endoplasmic reticulum or lysosomes. ABCD transporters play a role in transport of lipids, bile acids and vitamin B12 and associate with peroxisomal disorders. ABCD1 performs transport of coenzyme A esters of very-long-chain fatty acids (VLCFA) in peroxisomes and a number of mutations in ABCD1 gene were linked to an X-linked adrenoleucodystrophy (X-ALD). The role of ABCD transporters in tumour growth has not been studied in detail, but there is some evidence that ABCDs levels differ between undifferentiated stem or tumour cells and differentiated cells suggesting a possible link to tumorigenesis. In this mini-review, we discuss the available information about the role of ABCD transporters in cancer.

Immunolocalization and funtional role of scavenger receptor BI (SR-BI) and ATP-binding cassette A1 (ABC1)

2001 ◽  
Vol 120 (5) ◽  
pp. A678-A678
Author(s):  
I SUC ◽  
M BENDAYAN ◽  
E DELVIN ◽  
L BRISSETTE ◽  
C GAROFALO ◽  
...  
Keyword(s):  
Scavenger Receptor ◽  
Atp Binding ◽  
Scavenger Receptor Bi ◽  
Atp Binding Cassette

scholarly journals The Role of Apolipoprotein A-I Helix 10 in Apolipoprotein-mediated Cholesterol Efflux via the ATP-binding Cassette Transporter ABCA1

2002 ◽  
Vol 277 (42) ◽  
pp. 39477-39484 ◽  
Author(s):  
Stacey E. Panagotopulos ◽  
Scott R. Witting ◽  
Erica M. Horace ◽  
David Y. Hui ◽  
J. Nicholas Maiorano ◽  
...  
Keyword(s):  
Cholesterol Efflux ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Apolipoprotein A ◽  
Atp Binding Cassette

scholarly journals Role of the ATP-Binding Cassette TransporterAbcg2in the Phenotype and Function of Cardiac Side Population Cells

2008 ◽  
Vol 103 (8) ◽  
pp. 825-835 ◽  
Author(s):  
Otmar Pfister ◽  
Angelos Oikonomopoulos ◽  
Konstantina-Ioanna Sereti ◽  
Regina L. Sohn ◽  
Darragh Cullen ◽  
...  
Keyword(s):  
Side Population ◽  
Atp Binding ◽  
Side Population Cells ◽  
And Function ◽  
Atp Binding Cassette

ATP-binding cassette transporters and neurodegenerative diseases

2021 ◽  
Author(s):  
Jared S. Katzeff ◽  
Woojin Scott Kim
Keyword(s):  
Neurodegenerative Diseases ◽  
Abc Transporters ◽  
Brain Diseases ◽  
Atp Binding ◽  
Future Directions ◽  
Diverse Range ◽  
The Brain ◽  
Lateral Sclerosis ◽  
Atp Binding Cassette

Abstract ATP-binding cassette (ABC) transporters are one of the largest groups of transporter families in humans. ABC transporters mediate the translocation of a diverse range of substrates across cellular membranes, including amino acids, nucleosides, lipids, sugars and xenobiotics. Neurodegenerative diseases are a group of brain diseases that detrimentally affect neurons and other brain cells and are usually associated with deposits of pathogenic proteins in the brain. Major neurodegenerative diseases include Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis. ABC transporters are highly expressed in the brain and have been implicated in a number of pathological processes underlying neurodegenerative diseases. This review outlines the current understanding of the role of ABC transporters in neurodegenerative diseases, focusing on some of the most important pathways, and also suggests future directions for research in this field.

scholarly journals Role of ATP-binding cassette transporter A1 in suppressing lipid accumulation by glucagon-like peptide-1 agonist in hepatocytes

2020 ◽  
Vol 34 ◽  
pp. 16-26
Author(s):  
Jingya Lyu ◽  
Hitomi Imachi ◽  
Kensaku Fukunaga ◽  
Seisuke Sato ◽  
Toshihiro Kobayashi ◽  
...  
Keyword(s):  
Lipid Accumulation ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Atp Binding Cassette

scholarly journals Role of ATP-Binding Cassette and Solute Carrier Transporters in Erlotinib CNS Penetration and Intracellular Accumulation

2010 ◽  
Vol 17 (1) ◽  
pp. 89-99 ◽  
Author(s):  
Mohamed A. Elmeliegy ◽  
Angel M. Carcaboso ◽  
Michael Tagen ◽  
Feng Bai ◽  
Clinton F. Stewart
Keyword(s):  
Atp Binding ◽  
Intracellular Accumulation ◽  
Solute Carrier Transporters ◽  
Solute Carrier ◽  
Cns Penetration ◽  
Atp Binding Cassette

scholarly journals Cardioprotective Role of the Mitochondrial ATP-Binding Cassette Protein 1

2005 ◽  
Vol 97 (8) ◽  
pp. 740-742 ◽  
Author(s):  
Hossein Ardehali ◽  
Brian O’Rourke ◽  
Eduardo Marbán
Keyword(s):  
Atp Binding ◽  
Atp Binding Cassette
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