Plasma 25-Hydroxy-Vitamin D in Normal Subjects and Patients with Terminal Renal Failure, on Maintenance Haemodialysis and after Transplantation

1. Plasma 25-hydroxy-vitamin D concentration was measured in 40 normal subjects, 19 patients with terminal renal failure, 137 patients who had been on dialysis up to 11 years and in 17 renal transplant patients. 2. The mean plasma concentration of 25-hydroxy-vitamin D was below normal in patients with terminal renal failure and in patients who had been on maintenance haemodialysis for less than 1 year. The mean concentration in patients who had been on dialysis for more than 1 year and in renal transplant patients was normal. 3. The seasonal variation of plasma 25-hydroxy-vitamin D concentration found in the 58 patients on maintenance haemodialysis for more than 2 years is similar to that reported in normal subjects.

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Distinct impact of vitamin D insufficiency on calcitriol levels in chronic renal failure and renal transplant patients: a role for FGF23

Journal of Nephrology ◽

10.5301/jn.5000102 ◽

2012 ◽

Vol 25 (6) ◽

pp. 1108-1118 ◽

Cited By ~ 12

Author(s):

Sandro Mazzaferro ◽

Marzia Pasquali ◽

Francesco Pugliese ◽

Franco Citterio ◽

Antonio Gargiulo ◽

...

Keyword(s):

Vitamin D ◽

Renal Failure ◽

Chronic Renal Failure ◽

Renal Transplant ◽

Vitamin D Insufficiency ◽

Transplant Patients ◽

Renal Transplant Patients

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Abnormal erythrocyte choline transport in patients with chronic renal failure

Clinical Science ◽

10.1042/cs0800137 ◽

1991 ◽

Vol 80 (2) ◽

pp. 137-141 ◽

Cited By ~ 10

Author(s):

F. C. Fervenza ◽

D. Meredith ◽

J. C. Ellory ◽

B. M. Hendry

Keyword(s):

Renal Failure ◽

Peritoneal Dialysis ◽

Chronic Renal Failure ◽

Continuous Ambulatory Peritoneal Dialysis ◽

Normal Subjects ◽

Choline Transport ◽

Maintenance Haemodialysis ◽

Control Subjects ◽

Transplant Patients ◽

The Mean

1. Erythrocyte choline transport has been studied in nine patients on maintenance haemodialysis for chronic renal failure, six patients on continuous ambulatory peritoneal dialysis, 31 patients with renal transplants and in nine normal control subjects. 2. The mean maximum rate of choline influx (Vmax., measured at an extracellular choline concentration of 250 μmol/l) was 66.7 (sd 14.1) μmol h−1 l−1 cells in patients on haemodialysis, 87.8 (sd 18.5) μmol h−1 l−1 cells in patients on continuous ambulatory peritoneal dialysis and 30.5 (sd 4.9) μmol h−1 l−1 cells in control subjects. The increase in choline flux in patients on haemodialysis and patients on continuous ambulatory peritoneal dialysis compared with control subjects was highly significant (P < 0.001). 3. Renal transplant patients showed variable values for the Vmax. of choline influx (range 17.7-71.7 μmol h−1 l−1 cells). The values showed a signifcant negative correlation with creatinine clearance and this correlation correctly extrapolated to the maximum choline flux in normal subjects and in patients on dialysis. 4. The kinetics of choline transport have been studied in erythrocytes of patients on haemodialysis and control subjects in ‘zero-trans’ conditions after depletion of intracellular choline. The mean Vmax. in these conditions was 38.4 (sd 4.6) μmol h−1 l−1 cells in patients on haemodialysis compared with 14.2 (sd 3.7) μmol h−1 l−1 cells in control subjects. The mean Km under ‘zero-trans’ conditions was 19.4 (sd 2.4) μmol/l in patients on haemodialysis and 7.4 (sd 1.4) μmol/l in control subjects. These differences were significant (P < 0.001).

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