Studies on the Hypotensive Effect of High Potassium Intake in Patients with Essential Hypertension

1981 ◽  
Vol 61 (s7) ◽  
pp. 77s-80s ◽  
Author(s):  
Osamu Iimura ◽  
Toshiaki Kijima ◽  
Kenjiro Kikuchi ◽  
Akiyoshi Miyama ◽  
Toshiaki Ando ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Control Period ◽  
Extracellular Fluid ◽  
Hypotensive Effect ◽  
Fluid Volume ◽  
Electrolyte Balance ◽  
High Potassium ◽  
Plasma Aldosterone Concentration ◽  
Potassium Intake ◽  
Potassium Loading

1. In order to confirm and investigate the hypotensive effect of a high potassium intake we compared mean arterial pressure (MAP), water and electrolyte balance, plasma and urinary noradrenaline (NA), plasma renin activity (PRA) and plasma aldosterone concentration (PAC) in 20 inpatients with mild or moderate essential hypertension on a control diet (Na: 260, K: 75 mmol/day), and after high (K: 175 mmol/day) and low potassium diets (K: 25 mmol/day). 2. After potassium loading, urinary volume (UV) and urinary excretion of sodium (UNaV) and of potassium (UKV) were elevated, and MAP, body weight, plasma volume (PV), extracellular fluid volume (ECFV) and total exchangeable sodium (Nae) were reduced significantly. 3. After potassium loading, PRA, PAC, plasma and urinary NA increased and the pressor response to infused noradrenaline and angiotensin II decreased significantly. 4. The reduction of MAP after potassium loading correlated positively with PV and ECFV during the control period. In addition, significant correlations were found between ΔUV and ΔUNaV, —ΔPV and ΔU/NaV, —ΔPV and Δ plasma NA, and Δ plasma NA and Δ PRA. 5. Patients with low PRA had high PV, ECFV and Nae during the control period, and showed greater reductions of MAP, PV, ECFV and Nae after potassium loading. 6. After potassium restriction, UNaV, PRA and urinary NA decreased and PV increased, and MAP did not change significantly. 7. These results suggest that the hypotensive effect of high potassium intake may be caused by reduction of body fluid volume via augmentation of Na excretion.

48 High Potassium Intake Lowers Blood Pressure in Essential Hypertension

1984 ◽  
Vol 2 (1) ◽  
pp. 114 ◽  
Author(s):  
A Overlack ◽  
K O Stumpe ◽  
H M M??ller ◽  
R Kolloch ◽  
F Kr??ck
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
High Potassium ◽  
Potassium Intake

Diurnal potassium excretory cycles in the rat

1986 ◽  
Vol 250 (5) ◽  
pp. F930-F941 ◽  
Author(s):  
L. Rabinowitz ◽  
C. J. Wydner ◽  
K. M. Smith ◽  
H. Yamauchi
Keyword(s):  
Extracellular Fluid ◽  
Potassium Content ◽  
Extracellular Potassium ◽  
Dark Phase ◽  
Adrenal Steroids ◽  
Light Phase ◽  
High Potassium ◽  
Potassium Intake ◽  
Low Levels ◽  
Adrenalectomized Rats

Diurnal potassium cycles (DPC) were measured in unanesthetized undisturbed rats fed a liquid diet and maintained in a 12-h light-dark environment. A fourfold step increase in diet potassium content increased DPC amplitude without altering phase. After presentation of the high-potassium diet, the initial adaptive increase in excretion occurred within 1.5 h (diet given during dark phase) and within 6 h (diet given during light phase). On a day when food was withheld (no potassium intake), DPC were present but with a lowered amplitude. The amount of potassium excreted on a fasting day exceeded gut and extracellular fluid potassium content and was only modestly increased when rats were previously fed a high-potassium diet. In adrenalectomized rats that received no steroid replacement or received constant infusions of low levels of aldosterone, dexamethasone, or aldosterone plus dexamethasone, potassium balance and DPC were normal. It is concluded that the amplitude of DPC in the rat is determined in part by the availability of potassium from both intracellular and extracellular potassium pools; mechanisms independent of potassium intake can generate the DPC; and the presence or the cyclic secretion of adrenal steroids is not necessary for the generation of DPC in the rat.

Restraint vs. hindlimb suspension on fluid and electrolyte balance in rats

1996 ◽  
Vol 80 (6) ◽  
pp. 1993-2001 ◽  
Author(s):  
F. Bouzeghrane ◽  
S. Fagette ◽  
L. Somody ◽  
A. M. Allevard ◽  
C. Gharib ◽  
...  
Keyword(s):  
Plasma Volume ◽  
Extracellular Fluid ◽  
Fluid Volume ◽  
Extracellular Fluid Volume ◽  
Hindlimb Suspension ◽  
Sodium Thiocyanate ◽  
Electrolyte Balance ◽  
Experimental Protocol ◽  
Osmotic Load ◽  
Atrial Natriuretic

To determine the effect of hindlimb suspension on body fluid volume, salt and water balance, and relevant hormones, two series of experiments were performed in an experimental protocol including periods of isolation (7 days), horizontal attachment (7 days), and suspension (14 days). 1) During the first experiment, water and electrolyte balance, arginine vasopressin (AVP), and guanosine 3',5'- cyclic monophosphate (cGMP) were determined in urine, atrial natriuretic peptide in plasma and atria, and renin concentration and AVP in plasma in 30 rats. 2) During the second experiment, blood volume and extracellular fluid volume were measured by a dilution technique (Evans blue and sodium thiocyanate) in another 30 rats. We observed a pronounced and early effect of horizontal attachment on the renal variables. After 48 h, diuresis (49%), natriuresis (44%), kaliuresis (36%), osmotic load (39%), creatinine (28%), and AVP excretion (155%) were significantly increased in attached rats (P < 0.05). There was no short-term (24-h) effect of suspension on urine flow and Na+, K+, creatinine, and AVP excretion, but the urine cGMP decreased significantly (45%; P < 0.05). Significant decreases in natriuresis, kaliuresis, urine creatinine, and osmotic load occurred in the suspension group 7 days after suspension. After the 14-day tail suspension, plasma volume and extracellular fluid volume measured in suspended rats were not different from isolated rat values, whereas plasma volume increased by 15% (P < 0.05) in the attached rats. Plasma immunoreactive plasma atrial natriuretic levels of suspended rats were significantly reduced by 35% vs. isolated rats (P < 0.001) and by 18% vs. attached rats (P < 0.05). By using this experimental protocol, the physiological alterations revealed that suspension produced some acute and long-term effects, but the fixation to the suspension device, restraint, and confinement have their own influence on fluid distribution and renal function.

Plasma Volume and Extracellular Fluid Volume during Long-Term Treatment with Propranolol in Essential Hypertension

1972 ◽  
Vol 43 (2) ◽  
pp. 165-170 ◽  
Author(s):  
P. Sederberg-Olsen ◽  
H. Ibsen
Keyword(s):  
Essential Hypertension ◽  
Plasma Volume ◽  
Extracellular Fluid ◽  
Term Treatment ◽  
Fluid Volume ◽  
Extracellular Fluid Volume ◽  
Long Term Treatment ◽  
Significant Change

1. In ten patients with essential hypertension treated with propranolol (320 mg daily for 4 months) plasma volume and extracellular fluid volume were determined. 2. A significant increase in extracellular fluid volume (ECFV) was found, but there was no significant change in plasma volume. 3. The genesis of the increase found in ECFV is briefly discussed.

Extracellular Fluid Volume and Renal Indices in Essential Hypertension

1979 ◽  
Vol 1 (5) ◽  
pp. 557-576 ◽  
Author(s):  
A. Ch. Simon ◽  
M. E. Safar ◽  
J. A. Levenson ◽  
N. E. Aboras ◽  
J. M. Alexandre ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Extracellular Fluid ◽  
Fluid Volume ◽  
Extracellular Fluid Volume

SERIAL DETERMINATIONS OF EXTRACELLULAR FLUID VOLUME USING THE RADIOSULPHATE SPACE METHOD

1963 ◽  
Vol 41 (2) ◽  
pp. 497-510 ◽  
Author(s):  
Beverley Murphy ◽  
J. B. Dossetor ◽  
J. C. Beck
Keyword(s):  
Body Weight ◽  
Diurnal Variation ◽  
Extracellular Fluid ◽  
Time Of Day ◽  
Fluid Volume ◽  
Extracellular Fluid Volume ◽  
Blood Levels ◽  
Electrolyte Balance ◽  
Serum Samples ◽  
Space Method

The fate of injected and ingested radiosulphate was investigated. The appearance of radiosulphate in bile was shown to be very rapid. Ingested radiosulphate was rapidly and completely absorbed, peak blood levels occurring at 1 to 2 hours.The sulphate space method of measuring extracellular fluid volume was studied and a method adopted requiring two serum samples taken at 1/2 and 6 hours following injection. This procedure provided a convenient means of making independent observations of extracellular fluid volume as often as four times a day in individual subjects. When values for the sulphate space were compared in the same individuals under conditions similar with respect to diet, activity, and time of day, the coefficient of variation was calculated to be ± 5.7% or about ± 1% of body weight. Values among well-nourished subjects with no known abnormalities of water or electrolyte balance gave a mean of 17.5% body weight with a range of 13.5 to 22% body weight. Values among obese subjects averaged 12.8% body weight.Studies of the diurnal variation of the sulphate space made every 6 hours throughout the day suggested that in man, under conditions of uniform intake and normal activity, there is a diurnal variation of extracellular fluid volume, higher values occurring at night.

The Antihypertensive Effect of Dietary Potassium Chloride Loading in Rats with Adrenal Regeneration Hypertension

1984 ◽  
Vol 66 (2) ◽  
pp. 129-140 ◽  
Author(s):  
K. E. Milmer ◽  
T. Bennett ◽  
S. M. Gardiner
Keyword(s):  
Antihypertensive Effect ◽  
Sodium Intake ◽  
Extracellular Fluid ◽  
Plasma Potassium ◽  
Nacl Solution ◽  
Potassium Intake ◽  
Dietary Potassium ◽  
Peripheral Vasodilatation ◽  
Male Wistar Rats ◽  
Potassium Loading

1. Adrenal regeneration hypertension was induced in male Wistar rats by unilateral adrenal enucleation, contralateral adrenalectomy and the provision of a 1% (w/v) NaCl solution for drinking. 2. A fivefold increase in dietary KCl content caused a significant reduction in the systolic blood pressure of hypertensive rats but not of control rats. 3. During the increase in potassium intake there was a marked polydipsia. When 1% NaCl solution was the drinking fluid, the resultant increase in sodium intake was associated with an abolition of the antihypertensive effect of potassium loading, but when the sodium intake was held constant, the antihypertensive effect was maintained. 4. In rats with adrenal regeneration hypertension, plasma volume was significantly higher, and packed cell volume and plasma protein concentrations were significantly lower than in control rats. These differences were abolished after 4 days of dietary KCl supplementation. 5. Increased dietary potassium intake was associated with significantly lower serum aldosterone concentrations and significantly higher plasma potassium concentrations in adrenal enucleated rats compared with controls. 6. The possibility that a reduction in extracellular fluid volume (due to a natriuresis) and/or a peripheral vasodilatation contributed to the antihypertensive effect of KCl loading is discussed.

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