Altered Behaviour of Erythrocytes in Scleroderma

1983 ◽  
Vol 65 (5) ◽  
pp. 515-519 ◽  
Author(s):  
I. B. Kovacs ◽  
S. O. Sowemimo-Coker ◽  
J. D. T. Kirby ◽  
P. Turner
Keyword(s):  
Endothelial Cells ◽  
Systemic Sclerosis ◽  
Sialic Acid ◽  
Raynaud’S Phenomenon ◽  
Progressive Systemic Sclerosis ◽  
Normal Subjects ◽  
Vascular Abnormalities ◽  
Cultured Endothelial Cells ◽  
Deformability Of Erythrocytes ◽  
Electrophoretic Velocity

1. Filterability (deformability) of erythrocytes of patients with Raynaud's phenomenon together with progressive systemic sclerosis (PSS) was decreased compared with the filtration of erythrocytes from normal subjects. 2. PSS erythrocytes showed lower electrophoretic velocity and about 23% less neuraminidase-removable sialic acid density on their surface than the normal erythrocytes. 3. PSS erythrocytes showed more adherence to cultured endothelial cells than the control normal erythrocytes. 4. It is concluded that the increased rigidity and adherence of PSS erythrocytes-5-have pathological significance in the mechanism of vascular abnormalities in PSS.

Role of membrane sialic acid content in the adhesiveness of aged erythrocytes to human cultured endothelial cells

1987 ◽  
Vol 904 (2) ◽  
pp. 201-206 ◽  
Author(s):  
Didier Dhermy ◽  
Jacqueline Simeon ◽  
Marie-Paule Wautier ◽  
Pierre Boivin ◽  
Jean-Luc Wautier
Keyword(s):  
Endothelial Cells ◽  
Sialic Acid ◽  
Acid Content ◽  
Sialic Acid Content ◽  
Cultured Endothelial Cells

The Presence in Normal Plasma, Serum and Platelets of Factors That Stimulate the Production of Prostacyclin (PGI2) by Cultured Endothelial Cells

1983 ◽  
Vol 64 (4) ◽  
pp. 387-394 ◽  
Author(s):  
J. M. Seid ◽  
P. B. B. Jones ◽  
R. G. G. Russell
Keyword(s):  
Endothelial Cells ◽  
Vascular Endothelium ◽  
Normal Subjects ◽  
Disease States ◽  
Normal Plasma ◽  
Cultured Endothelial Cells ◽  
Porcine Endothelial Cells ◽  
Dose Dependent ◽  
Prostacyclin Production

1. The effect of plasma and serum from normal subjects on the production of prostacyclin by cultured porcine endothelial cells was investigated. 2. Both plasma and serum from all subjects studied significantly stimulated the production of prostacyclin by cultured endothelial cells, measured by the radioimmunoassay of its stable metabolite 6-oxoprostaglandin F1α. 3. Serum caused a consistently greater stimulation than plasma from the same individual. The stimulation was dose-dependent and inhibited by indomethacin. Heparin added to serum also inhibited this response. 4. Extracts from isolated washed platelets were tested for their ability to increase prostacyclin production. Extracts from platelets which had been induced to aggregate and release their granule contents in response to thrombin, caused stimulation. 5. These results indicated the invariable presence in plasma and serum of factors that stimulate the production of prostacyclin by endothelial cells in vitro. At least one of these factors is derived from platelets. These factors may be involved in the regulation of prostacyclin production by the vascular endothelium under normal conditions and in disease states.

Endothelin-1 and Cold Provocation in Health, Primary Raynaud's Phenomenon, and Progressive Systemic Sclerosis

1996 ◽  
Vol 52 (2) ◽  
pp. 193-197 ◽  
Author(s):  
Janine Dörffler-Melly ◽  
Thomas F. Lüscher ◽  
Martin Wenk ◽  
Shenghua Wen ◽  
Alfred Bollinger ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Raynaud’S Phenomenon ◽  
Progressive Systemic Sclerosis ◽  
Raynaud's Phenomenon ◽  
Endothelin 1 ◽  
Primary Raynaud’S Phenomenon ◽  
Cold Provocation
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