Effect of a meal containing protein on lithium clearance and plasma immunoreactive atrial natriuretic peptide in man

1988 ◽  
Vol 75 (2) ◽  
pp. 151-157 ◽  
Author(s):  
L. R. Solomon ◽  
J. C. Atherton ◽  
H. Bobinski ◽  
S. L. Cottam ◽  
C. Gray ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Protein Content ◽  
Natriuretic Peptide ◽  
Proximal Tubules ◽  
High Protein ◽  
Lithium Clearance ◽  
Protein Meal ◽  
Low Protein ◽  
High Protein Meal ◽  
Atrial Natriuretic

1. The effect of meals with a high and low protein content and of the fasting state on renal function and plasma atrial natriuretic peptide was studied in water-loaded normal volunteers. 2. Creatinine clearance increased after the high protein meal, but did not change after the low protein meal or while fasting. Observations of similar increases in urine sodium and potassium excretion and a transient decrease in urine flow after both meals suggest that the protein content of the meal is not an important contributory factor in these responses to feeding. 3. Absolute delivery of sodium and water out of the proximal tubules (assessed by the lithium clearance method) was higher after both meals than while fasting; fractional lithium clearance was higher after the low protein meal than the high protein meal and while fasting. Absolute reabsorption from proximal tubules was increased after only the high protein meal. 4. A transient decrease in the fraction of water delivered to distal nephron segments that appeared in the urine (fractional distal water excretion) was observed after both meals. Fractional distal sodium excretion and absolute distal sodium and water reabsorption increased after both meals. 5. Since plasma atrial natriuretic peptide either decreased (high protein meal) or remained unchanged (low protein meal and fasting), it is unlikely that this hormone is involved in the hyperfiltration after the high protein meal and the natriuresis after both high and low protein meals.

Role of atrial natriuretic peptide in the increase in glomerular filtration rate induced by a protein meal

1990 ◽  
Vol 78 (5) ◽  
pp. 481-485 ◽  
Author(s):  
S. C. Tam ◽  
L. S. Tang ◽  
C. K. Lai ◽  
M. G. Nicholls ◽  
R. Swaminathan
Keyword(s):  
Glomerular Filtration Rate ◽  
Atrial Natriuretic Peptide ◽  
Creatinine Clearance ◽  
Glomerular Filtration ◽  
Natriuretic Peptide ◽  
Filtration Rate ◽  
Protein Meal ◽  
Plasma Atrial Natriuretic Peptide ◽  
High Protein Meal ◽  
Atrial Natriuretic

1. The increase in glomerular filtration rate after a protein meal is believed to be mediated by hormonal factors. Since natriuresis is often observed after a protein meal, it was postulated that the increase in glomerular filtration rate after a protein meal might be mediated by atrial natriuretic peptide. 2. Subjects were given a low, medium or high protein meal. Fluid intake was controlled so as to avoid significant extracellular fluid volume expansion. It was found that the creatinine clearance, the urea excretion, the fractional sodium excretion and the potassium excretion were elevated in all subjects after protein meals (P <0.05). These effects were not observed in subjects given a carbohydrate control meal. 3. The plasma atrial natriuretic peptide concentrations remained unchanged in all subjects except those given a high protein meal (P <0.05). There was no significant relationship between plasma atrial natriuretic peptide concentrations and creatinine clearance before or after a protein meal. 4. The data suggest that a high protein meal induces a minor increase in plasma atrial natriuretic peptide concentration, whereas a low or medium protein meal does not. It is unlikely that the change in creatinine clearance after a protein meal can be explained by a change in plasma atrial natriuretic peptide levels.

Effect of low dose infusion of atrial natriuretic peptide on renal function in man

1988 ◽  
Vol 75 (4) ◽  
pp. 403-410 ◽  
Author(s):  
L. R. Solomon ◽  
J. C. Atherton ◽  
H. Bobinski ◽  
V. Hillier ◽  
R. Green
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Low Dose ◽  
Plasma Renin ◽  
Lithium Clearance ◽  
Plasma Aldosterone Concentration ◽  
Proximal Tubular Function ◽  
Small Change ◽  
Magnesium Excretion ◽  
Atrial Natriuretic

1. The effects of the infusion of a low dose (2 pmol min−1 kg−1 for 3 h) of human atrial natriuretic peptide (hANP) were studied in seven healthy volunteers undergoing a water diuresis. Lithium clearance was used to monitor proximal tubular function. 2. hANP increased urine flow rate, sodium, calcium and magnesium excretion without significant changes in potassium and phosphate excretion, heart rate or blood pressure. 3. hANP caused a small change in fractional lithium clearance, and larger changes in distal nephron handling of sodium and water. 4. Plasma renin activity tended to decrease during the infusion of hANP, while plasma aldosterone concentration decreased during and increased after stopping the infusion of hANP. 5. The data suggest that hANP inhibits the reabsorption of sodium and water by an action on distal segments of the nephron and perhaps the proximal tubule. Inhibition of renin and aldosterone secretion may contribute to the natriuresis.

Increased serum sulfate after protein loading in adult humans

1991 ◽  
Vol 69 (1) ◽  
pp. 25-27 ◽  
Author(s):  
David E. C. Cole ◽  
Anne M. Thurgood ◽  
Susan J. Whiting
Keyword(s):  
Sulfur Metabolism ◽  
High Protein ◽  
Protein Meal ◽  
Protein Loading ◽  
Low Protein ◽  
High Protein Meal ◽  
Protein Feeding ◽  
Sulfate Metabolism ◽  
Adult Volunteers ◽  
Serum Sulfate

To determine the effects of a protein loading on sulfate metabolism in humans, we monitored serum sulfate concentrations in 12 fasting adult volunteers fed a high-protein meal of egg white and an isocaloric low-protein meal. With each subject serving as his or her own control, we found that mean serum sulfate rose only slightly with the low-protein meal but was significantly higher with high-protein loading at 3 and 3.5 h. The median of the peak sulfate concentration was 57% greater than baseline with the high-protein meal versus 11% with no loading. Since changes in serum sulfate have been shown to influence the rate of sulfation for a variety of different acceptor molecules, these observations indicate a means by which protein feeding may simultaneously influence diverse metabolic pathways.Key words: serum sulfate, protein intake, sulfur metabolism, human dietary studies.

Systemic Factors and Renal Hemodynamic Effects of High-Protein Meal versus Low-Protein Meal in Conscious Dogs

Nephron ◽  
1994 ◽  
Vol 68 (1) ◽  
pp. 112-117 ◽  
Author(s):  
Edward T. Zawada ◽  
David A. Saelens ◽  
Fereidon K. Alavi ◽  
Jeanie M. Lembke
Keyword(s):  
High Protein ◽  
Conscious Dogs ◽  
Hemodynamic Effects ◽  
Protein Meal ◽  
Low Protein ◽  
Renal Hemodynamic ◽  
High Protein Meal ◽  
Systemic Factors

scholarly journals Ouabain-insensitive Na+-ATPase of proximal tubules is an effector for urodilatin and atrial natriuretic peptide

2004 ◽  
Vol 1660 (1-2) ◽  
pp. 93-98 ◽  
Author(s):  
C. Caruso-Neves ◽  
D. Vives ◽  
C. Dantas ◽  
C.M. Albino ◽  
L.M. Fonseca ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Proximal Tubules ◽  
Atrial Natriuretic

How important are suppression of aldosterone and stimulation of atrial natriuretic peptide secretion in the natriuretic response to an acute sodium load in man?

1991 ◽  
Vol 80 (4) ◽  
pp. 293-299 ◽  
Author(s):  
D. R. J. Singer ◽  
D. G. Shirley ◽  
N. D. Markandu ◽  
M. A. Miller ◽  
M. G. Buckley ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Sodium Excretion ◽  
Plasma Aldosterone ◽  
Urinary Sodium ◽  
Saline Infusion ◽  
Lithium Clearance ◽  
Saline Loading ◽  
Sodium Load ◽  
Atrial Natriuretic

1. Aldosterone is suppressed by sodium loading. We studied the contribution of this decrease in plasma aldosterone to the natriuresis after acute sodium loading in healthy volunteers. 2. Two litres of saline [0.9% (w/v) NaCl] were infused during the second hour of a 6 h infusion of aldosterone (3 pmol min−1 kg−1) or placebo in eight healthy young men. On the placebo day, plasma aldosterone decreased by 30 min after the start of saline infusion and remained suppressed. During aldosterone infusion, plasma aldosterone was maintained at around 400 pmol/l. 3. Urinary sodium excretion, lithium clearance and plasma atrial natriuretic peptide increased and plasma renin activity decreased after saline infusion, whether or not aldosterone was infused. However, from 60 to 240 min after saline infusion, natriuresis was significantly less during aldosterone infusion than on the placebo day. In addition, saline loading led to a progressive increase in the ratio of sodium clearance to lithium clearance, used as an index of the fractional distal tubular rejection of sodium, and in the ratio of urinary sodium to potassium. These increases were prevented by the infusion of aldosterone. 4. This study suggests that there are differences in the mechanisms determining the early and the later responses to an acute sodium load. Suppression of aldosterone may explain much of the later increase in natriuresis after saline infusion. In addition, the results are consistent with a role for atrial natriuretic peptide in the immediate increase in sodium excretion after saline loading.

Synthesis and secretion of atrial natriuretic peptide by BON cells: Stimulation by PMA and cGMP

2001 ◽  
Vol 120 (5) ◽  
pp. A682-A682
Author(s):  
W GOWERJR ◽  
G CARTER ◽  
C LANDON ◽  
W GOWERIII ◽  
J DIETZ ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Bon Cells ◽  
Atrial Natriuretic
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