Interleukin-1 potentiates the development of collagen-induced arthritis in mice

1989 ◽  
Vol 76 (5) ◽  
pp. 535-538 ◽  
Author(s):  
L. M. Killar ◽  
C. J. Dunn
Keyword(s):  
Immune Response ◽  
Interleukin 1 ◽  
Subcutaneous Administration ◽  
Type Ii Collagen ◽  
Interleukin 1Β ◽  
Type Ii ◽  
Collagen Induced Arthritis

1. The subcutaneous administration of recombinant human interleukin-1β (rhIL-1β) was found to induce an increased incidence and earlier onset of collagen-induced arthritis in mice. 2. The rhIL-1β had different effects, depending on when it was administered after collagen-immunization. 3. The effect of rhIL-1β may be due, in part, to augmentation of the immune response to type II collagen. 4. Interleukin-1-accelerated, collagen-induced arthritis will provide a useful model for investigating the role of interleukin-1 in the regulation of arthritic diseases, and the development of anti-arthritic therapeutics.

Interleukin 1 mediated acceleration of type II collagen-induced arthritis: Effects of anti-inflammatory or anti-arthritic drugs

1991 ◽  
Vol 33 (3-4) ◽  
pp. 300-309 ◽  
Author(s):  
J. T. Hom ◽  
V. L. Gliszczynski ◽  
H. W. Cole ◽  
A. M. Bendele
Keyword(s):  
Interleukin 1 ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Collagen Induced Arthritis ◽  
Anti Inflammatory

The Influence of HLA-DR4 (0401) on the Immune Response to Type II Collagen and the Development of Collagen Induced Arthritis in Mice

2002 ◽  
Vol 18 (2) ◽  
pp. 95-103 ◽  
Author(s):  
Dequn Wang ◽  
Jonathan A Hill ◽  
Ewa Cairns ◽  
David A Bell
Keyword(s):  
Immune Response ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Collagen Induced Arthritis

Involvement of interleukin-1-like factor(s) in type II collagen-induced arthritis in mice

1990 ◽  
Vol 26 (2) ◽  
pp. 171-175 ◽  
Author(s):  
T. Kasama ◽  
K. Kobayashi ◽  
H. Kanemitsu ◽  
K. Nakatani ◽  
S. Kaga ◽  
...  
Keyword(s):  
Interleukin 1 ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Collagen Induced Arthritis

scholarly journals The effect of an interleukin-1 receptor antagonist protein on type ii collagen–induced arthritis and antigen-induced arthritis in mice

1993 ◽  
Vol 36 (9) ◽  
pp. 1305-1314 ◽  
Author(s):  
Paul H. Wooley ◽  
Janey D. Whalen ◽  
Darryl L. Chapman ◽  
Ann E. Berger ◽  
Karen A. Richard ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Collagen Induced Arthritis ◽  
Interleukin 1 Receptor Antagonist

Role of cyclooxygenase-2, but not cyclooxygenase-1, on type II collagen-induced arthritis in DBA/1J mice

2003 ◽  
Vol 66 (6) ◽  
pp. 1055-1060 ◽  
Author(s):  
Takehiro Ochi ◽  
Yoshitaka Ohkubo ◽  
Seitaro Mutoh
Keyword(s):  
Type Ii Collagen ◽  
Cyclooxygenase 2 ◽  
Type Ii ◽  
Collagen Induced Arthritis ◽  
Cyclooxygenase 1

Oral administration of type-II collagen peptide 250–270 suppresses specific cellular and humoral immune response in collagen-induced arthritis

2007 ◽  
Vol 122 (1) ◽  
pp. 75-84 ◽  
Author(s):  
Ping Zhu ◽  
Xiao-Yan Li ◽  
Hong-Kun Wang ◽  
Jun-Feng Jia ◽  
Zhao-Hui Zheng ◽  
...  
Keyword(s):  
Immune Response ◽  
Oral Administration ◽  
Humoral Immune Response ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Collagen Induced Arthritis ◽  
Humoral Immune ◽  
Collagen Peptide

Interleukin-1 enhances the development of type II collagen-induced arthritis only in susceptible and not in resistant mice

1992 ◽  
Vol 62 (1) ◽  
pp. 56-65 ◽  
Author(s):  
Joanne T. Hom ◽  
Harlan Cole ◽  
Thomas Estridge ◽  
Virginia L. Gliszczynski
Keyword(s):  
Interleukin 1 ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Collagen Induced Arthritis

scholarly journals The impact of Clonorchis sinensis infection on immune response in mice with type II collagen-induced arthritis

2020 ◽  
Author(s):  
xiangyang li ◽  
Ying Yang ◽  
Su-Ping Qin ◽  
Fan-Yun Kong ◽  
Chao Yan ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Respiratory Exchange Ratio ◽  
Clonorchis Sinensis ◽  
Joint Inflammation ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Oral Gavage ◽  
Collagen Induced Arthritis ◽  
The Impact

Abstract Background: Clonorchis sinensis infection could trigger strong immune responses in mice and humans. However, whether the C.sinensis infection has an impact on arthritis is unknown. Here we investigated the effect of C.sinensis infection on type II collagen-induced arthritis in BALB/c mice. Results: The mice were firstly infected with 45 C.sinensis metacercariae by oral gavage. Four weeks later, arthritis in mice was induced by type II collagen. Joint inflammation with severe redness and swelling in hind paws was observed in type II collagen-induced arthritis (CIA) mice. Besides, the physical activity was significantly reduced, but the respiratory exchange ratio was increased in CIA mice. Compared with CIA mice, C.sinensis infection could increase the severity of arthritis in CIA mice, based on the results of disease score and pathological changes. Compared to CIA mice, increased neutrophils and Ly6C hi monocytes, decreased B cells and CD4 + T cells, were found in C.sinensis infected CIA mice. Besides these, C.sinensis infected mice also displayed significantly higher levels of serum IL-4 and IL-17 than those in CIA mice. Conclusions: Taken together, our data suggest that C.sinensis infection have a bad effect on arthritis, and could induce the abnormality of the immune response in mice with CIA.

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