Effect of Human Growth Hormone on Whole Body Protein Turnover in Patients Treated Long-Term with Glucocorticoids

1991 ◽  
Vol 80 (s24) ◽  
pp. 12P-12P
Author(s):  
WM Bennet ◽  
MW Haymond
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Protein Turnover ◽  
Human Growth ◽  
Whole Body ◽  
Body Protein

Monoclonal antibody enhancement of the effects of human growth hormone on growth and body composition in mice

1988 ◽  
Vol 117 (1) ◽  
pp. 85-90 ◽  
Author(s):  
A. T. Holder ◽  
J. A. Blows ◽  
R. Aston ◽  
P. C. Bates
Keyword(s):  
Monoclonal Antibody ◽  
Growth Hormone ◽  
Body Composition ◽  
Body Weight ◽  
Weight Gain ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Whole Body ◽  
Body Protein ◽  
Dwarf Mice

ABSTRACT Dwarf mice were treated for 10 days with phosphate-buffered saline (PBS), human growth hormone (hGH) or hGH with monoclonal antibody EB1 (hGH/MAB-EB1); for each treatment there were three groups which received 50, 75 or 100% of the amount of food eaten when available ad libitum. The PBS control groups lost more or gained less weight than equivalent groups receiving hGH alone, and mice given hGH/MAB-EB1 showed a greater weight gain than those in comparable groups receiving hGH alone. When weight gain or loss was expressed as g/g food eaten, groups treated with hGH gained more or lost less than the PBS groups. Similarly, weight gain/g food was significantly greater in hGH/MAB-EB1 animals than in the comparable groups given hGH alone. A similar pattern of response was observed for increases in tail length and uptake of 35SO42− into costal cartilage in vivo. For mice given hGH alone, fat content was decreased compared with that in the equivalent group given PBS, and mice treated with hGH/MAB-EB1 had less fat than the equivalent group given hGH alone. Administration of hGH alone caused a concomitant increase in protein content and body weight such that, compared with mice given PBS, there was no significant increase in protein as a proportion of body weight. However, hGH/MAB-EB1 caused an increase in whole body protein which was significantly greater than that for the equivalent group given hGH alone, when expressed as per cent body weight. Monoclonal antibody EB1 has been shown to enhance the actions of hGH on growth and body composition in Snell dwarf mice and to increase food conversion efficiency. J. Endocr. (1988) 117,85–90

scholarly journals RARE ACQUIRED NEUROLOGICAL DISORDERS IN TWO PATIENTS ON LONG-TERM HUMAN GROWTH HORMONE (hGH) THERAPY

1981 ◽  
Vol 15 (12) ◽  
pp. 1562-1562
Author(s):  
Abdollah Sadeghi-Nejad ◽  
Joseph I Wolfsdorf ◽  
Boris Senior
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Neurological Disorders ◽  
Human Growth

Effects of growth hormone and/or sex steroid administration on whole-body protein turnover in healthy aged women and men

Metabolism ◽  
2005 ◽  
Vol 54 (9) ◽  
pp. 1162-1167 ◽  
Author(s):  
Xin Huang ◽  
Marc R. Blackman ◽  
Karen Herreman ◽  
Katharine M. Pabst ◽  
S. Mitchell Harman ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Protein Turnover ◽  
Whole Body ◽  
Sex Steroid ◽  
Body Protein ◽  
Steroid Administration

scholarly journals One-Year Data from a Long-Term Phase IV Study of Recombinant Human Growth Hormone in Short Children Born Small for Gestational Age

2014 ◽  
Vol 4 (1-2) ◽  
pp. 1-13 ◽  
Author(s):  
Hans-Peter Schwarz ◽  
Dorota Birkholz-Walerzak ◽  
Mieczyslaw Szalecki ◽  
Mieczyslaw Walczak ◽  
Corina Galesanu ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Recombinant Human Growth Hormone ◽  
Human Growth ◽  
Short Children ◽  
One Year ◽  
Phase Iv

Altered lipid kinetics in adjuvant recombinant human growth hormone-treated multiple-trauma patients

1994 ◽  
Vol 267 (4) ◽  
pp. E560-E565 ◽  
Author(s):  
M. Jeevanandam ◽  
S. R. Petersen
Keyword(s):  
Growth Hormone ◽  
Multiple Trauma ◽  
Human Growth Hormone ◽  
Recombinant Human Growth Hormone ◽  
Human Growth ◽  
Whole Body ◽  
Constant Infusion ◽  
Control Group ◽  
Trauma Patients ◽  
Oxidation Rates

Adjuvant recombinant human growth hormone therapy during the postinjury period may improve the efficiency of utilization of body energy stores. In a group of 20 severely injured highly catabolic hypermetabolic adult multiple-trauma victims, we have investigated the basic lipid kinetics of trauma (study I) and its modification after 7 days of intravenous feeding (total parenteral nutrition) with (group H, n = 10) or without (group C, n = 10) daily rhGH (0.15 mg somatotropin.kg-1.day-1) intramuscular injections (study II). Whole body lipolysis rate (2-stage primed constant infusion of 10% glycerol), substrate net oxidation rates (indirect calorimetry), and plasma levels of hormones were determined. Compared with the control group (group C) the treatment group (group H) showed significantly (P = 0.006) enhanced rates of lipolysis and free fatty acid reesterification (10 +/- 2 to 18 +/- 2 kcal.kg-1.day-1, P = 0.05). As a function of resting energy expenditure (REE), a trend of increased net glucose oxidation [32 +/- 10 vs. 56 +/- 7% REE, not significant (NS)] and decreased fat (40 +/- 8 vs. 25 +/- 5% REE, NS) and protein oxidation rates (28 +/- 2 vs. 19 +/- 2% REE, P = 0.007) were also indicated. The simultaneous operation of increased lipolytic and reesterification processes may allow the adipocyte to respond rapidly to changes in peripheral metabolic fuel requirements in injury.

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