scholarly journals Recombinant human growth hormone improves muscle amino acid uptake and whole-body protein metabolism in chronic hemodialysis patients

2005 ◽  
Vol 82 (6) ◽  
pp. 1235-1243 ◽  
Author(s):  
Lara B Pupim ◽  
Paul J Flakoll ◽  
Chang Yu ◽  
T Alp Ikizler
Keyword(s):  
Growth Hormone ◽  
Protein Metabolism ◽  
Recombinant Human Growth Hormone ◽  
Human Growth ◽  
Amino Acid Uptake ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis ◽  
Whole Body ◽  
Acid Uptake ◽  
Body Protein

Leucine and glucose kinetics during growth hormone treatment in intrauterine growth-retarded preterm infants

1996 ◽  
Vol 270 (3) ◽  
pp. E451-E455
Author(s):  
L. Van Toledo-Eppinga ◽  
M. C. Houdijk ◽  
H. A. Delemarre-Van De Waal ◽  
C. Jakobs ◽  
H. N. Lafeber
Keyword(s):  
Growth Hormone ◽  
Preterm Infants ◽  
Recombinant Human Growth Hormone ◽  
Human Growth ◽  
Treated Group ◽  
Oral Feeding ◽  
Whole Body ◽  
Glucose Kinetics ◽  
Body Protein ◽  
Intrauterine Growth

The present study was performed with the objective to investigate the possible effects of recombinant human growth hormone (rhGH) supplementation on protein and glucose metabolism during the early postnatal period in seven intrauterine growth-retarded (IUGR) preterm infants. Eight infants were studied as controls. The metabolic rate was measured by indirect calorimetry, and whole body protein and glucose kinetics were measured using constant-rate infusions of [1-13C] leucine and [U-13C]glucose during continuous adequate oral feeding. Energy expenditure was similar in both groups. In the rhGH-treated group of infants, leucine turnover (470 +/- 76 vs. 409 +/- micromol/ kg/day), leucine used for protein synthesis (402 +/- 72 vs. 337 +/- 36 micromol /kg/day), and leucine derived from protein breakdown (365 +/- 71 vs. 304 +/- 41 micromol/kg/day) were increased. However, net leucine balance was not increased (37 +/- 17 vs. 34 +/- 13 micromol/kg/day). The total rate of appearance of glucose was 10.1 +/- 1.2 vs. 10.0 +/- 1.3 mg/kg/min. We suggest that immediate postnatal treatment with rhGH is not effective in stimulating protein gain and has no effect on glucose kinetics in IUGR preterm infants.

Altered lipid kinetics in adjuvant recombinant human growth hormone-treated multiple-trauma patients

1994 ◽  
Vol 267 (4) ◽  
pp. E560-E565 ◽  
Author(s):  
M. Jeevanandam ◽  
S. R. Petersen
Keyword(s):  
Growth Hormone ◽  
Multiple Trauma ◽  
Human Growth Hormone ◽  
Recombinant Human Growth Hormone ◽  
Human Growth ◽  
Whole Body ◽  
Constant Infusion ◽  
Control Group ◽  
Trauma Patients ◽  
Oxidation Rates

Adjuvant recombinant human growth hormone therapy during the postinjury period may improve the efficiency of utilization of body energy stores. In a group of 20 severely injured highly catabolic hypermetabolic adult multiple-trauma victims, we have investigated the basic lipid kinetics of trauma (study I) and its modification after 7 days of intravenous feeding (total parenteral nutrition) with (group H, n = 10) or without (group C, n = 10) daily rhGH (0.15 mg somatotropin.kg-1.day-1) intramuscular injections (study II). Whole body lipolysis rate (2-stage primed constant infusion of 10% glycerol), substrate net oxidation rates (indirect calorimetry), and plasma levels of hormones were determined. Compared with the control group (group C) the treatment group (group H) showed significantly (P = 0.006) enhanced rates of lipolysis and free fatty acid reesterification (10 +/- 2 to 18 +/- 2 kcal.kg-1.day-1, P = 0.05). As a function of resting energy expenditure (REE), a trend of increased net glucose oxidation [32 +/- 10 vs. 56 +/- 7% REE, not significant (NS)] and decreased fat (40 +/- 8 vs. 25 +/- 5% REE, NS) and protein oxidation rates (28 +/- 2 vs. 19 +/- 2% REE, P = 0.007) were also indicated. The simultaneous operation of increased lipolytic and reesterification processes may allow the adipocyte to respond rapidly to changes in peripheral metabolic fuel requirements in injury.

Effect of Human Growth Hormone and Insulin-Like Growth Factor I on Whole-Body Leucine and Estimates of Protein Metabolism

1993 ◽  
Vol 40 (1-3) ◽  
pp. 92-94 ◽  
Author(s):  
Morey W. Haymond ◽  
Fritz Horber ◽  
Pierpaolo De Feo ◽  
Steven E. Kahn ◽  
Nelly Mauras
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Human Growth Hormone ◽  
Protein Metabolism ◽  
Human Growth ◽  
Whole Body ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

Growth hormone and testosterone interact positively to enhance protein and energy metabolism in hypopituitary men

2005 ◽  
Vol 289 (2) ◽  
pp. E266-E271 ◽  
Author(s):  
James Gibney ◽  
Troels Wolthers ◽  
Gudmundur Johannsson ◽  
A. Margot Umpleby ◽  
Ken K. Y. Ho
Keyword(s):  
Growth Hormone ◽  
Protein Metabolism ◽  
Resting Energy Expenditure ◽  
Whole Body ◽  
Combined Treatments ◽  
Gh Treatment ◽  
Additional Increase ◽  
Body Protein ◽  
Igf I ◽  
The Impact

We investigated the impact of growth hormone (GH) alone, testosterone (T) alone, and combined GH and T on whole body protein metabolism. Twelve hypopituitary men participated in two studies. Study 1 compared the effects of GH alone with GH plus T, and study 2 compared the effects of T alone with GH plus T. IGF-I, resting energy expenditure (REE), and fat oxidation (Fox) and rates of whole body leucine appearance (Ra), oxidation (Lox), and nonoxidative leucine disposal (NOLD) were measured. In study 1, GH treatment increased mean plasma IGF-I ( P < 0.001). GH did not change leucine Ra but reduced Lox ( P < 0.02) and increased NOLD ( P < 0.02). Addition of T resulted in an additional increase in IGF-I ( P < 0.05), reduction in Lox ( P < 0.002), and increase in NOLD ( P < 0.002). In study 2, T alone did not alter IGF-I levels. T alone did not change leucine Ra but reduced Lox ( P < 0.01) and increased NOLD ( P < 0.01). Addition of GH further reduced Lox ( P < 0.05) and increased NOLD ( P < 0.05). In both studies, combined treatments on REE and Fox were greater than either alone. In summary, GH-induced increase of circulating IGF-I is augmented by T, which does not increase IGF-I in the absence of GH. T and GH exerted independent and additive effects on protein metabolism, Fox and REE. The anabolic effects of T are independent of circulating IGF-I.

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