Impaired cardiovascular responses to baroreflex stimulation in open-angle and normal-pressure glaucoma

2002 ◽  
Vol 102 (6) ◽  
pp. 623-630 ◽  
Author(s):  
Clive M. BROWN ◽  
Matthias DÜTSCH ◽  
Georg MICHELSON ◽  
Bernhard NEUNDÖRFER ◽  
Max J. HILZ
Keyword(s):  
Blood Vessels ◽  
Open Angle Glaucoma ◽  
Cardiovascular Responses ◽  
Normal Pressure ◽  
Control Group ◽  
Open Angle ◽  
Baroreflex Control ◽  
Rr Interval ◽  
Normal Pressure Glaucoma ◽  
Interval Response

Autonomic neuropathy may contribute to the pathophysiology of both open-angle and normal-pressure glaucoma. However, autonomic function has not been studied extensively in these diseases. We evaluated baroreflex control of the heart and blood vessels in open-angle and normal-pressure glaucoma. We studied 14 patients with open-angle glaucoma, 15 with normal-pressure glaucoma and 17 controls. Sinusoidal neck suction (0 to -30mmHg) was applied at 0.1Hz to assess the sympathetic modulation of the heart and blood vessels, and at 0.2Hz to assess the effect of parasympathetic stimulation on the heart. Baseline recordings showed no significant differences between the groups. The RR-interval response of the controls to neck suction at 0.1Hz (3.88±0.32 to 6.65±0.44lnms2) was significantly greater than that of the open-angle glaucoma patients (4.22±0.28 to 5.56±0.26lnms2) and the normal-pressure glaucoma patients (4.53±0.27 to 5.53±0.37lnms2) (P<0.05). The low-frequency power of diastolic blood pressure increased significantly in the controls (0.48±0.08 to 2.76±0.72mmHg2; P<0.01) during 0.1Hz neck suction, but did not change significantly in patients with either open-angle glaucoma or normal-pressure glaucoma. The RR-interval response in the control group (3.45±0.52lnms2) to neck suction at 0.2Hz was significantly greater than that of the normal-pressure glaucoma patients (1.84±0.32lnms2) and the open-angle glaucoma patients (1.58±0.35lnms2) (P<0.05). The decreased sympathetic and parasympathetic modulation during baroreceptor stimulation in patients with open-angle glaucoma and normal-pressure glaucoma suggests that autonomic dysfunction may contribute to the pathogenesis of both diseases.

Impaired cardiovascular responses to baroreflex stimulation in open-angle and normal-pressure glaucoma

2002 ◽  
Vol 102 (6) ◽  
pp. 623 ◽  
Author(s):  
Clive M. BROWN ◽  
Matthias DÜTSCH ◽  
Georg MICHELSON ◽  
Bernhard NEUNDRFER ◽  
Max J. HILZ
Keyword(s):  
Cardiovascular Responses ◽  
Normal Pressure ◽  
Open Angle ◽  
Normal Pressure Glaucoma ◽  
Baroreflex Stimulation

scholarly journals Hypothesis-independent pathway analysis implicates GABA and Acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma

2014 ◽  
Vol 133 (10) ◽  
pp. 1319-1330 ◽  
Author(s):  
Jessica N. Cooke Bailey ◽  
Brian L. Yaspan ◽  
Louis R. Pasquale ◽  
Michael A. Hauser ◽  
Jae H. Kang ◽  
...  
Keyword(s):  
Pathway Analysis ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Normal Pressure ◽  
Open Angle ◽  
Acetyl Coa ◽  
Normal Pressure Glaucoma

scholarly journals Comparison of T Helper Cell Patterns in Primary Open-Angle Glaucoma and Normal-Pressure Glaucoma

2018 ◽  
Vol 24 ◽  
pp. 1988-1996 ◽  
Author(s):  
Chunyu Guo ◽  
Ningbo Wu ◽  
Xiaoyin Niu ◽  
Yue Wu ◽  
Dongfeng Chen ◽  
...  
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Normal Pressure ◽  
T Helper Cell ◽  
Helper Cell ◽  
Open Angle ◽  
T Helper ◽  
Cell Patterns ◽  
Normal Pressure Glaucoma

Clinical efficacy of osteopathic correction in the complex treatment of patients with unoperated open-angle glaucoma

2020 ◽  
pp. 97-105
Author(s):  
E. N. Simakova ◽  
O. V. Stenkova
Keyword(s):  
Intraocular Pressure ◽  
Drug Therapy ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Randomized Study ◽  
Main Group ◽  
Control Group ◽  
Open Angle ◽  
Complex Treatment ◽  
Hypotensive Drug

Introduction. Glaucoma is one of the most significant eye diseases. It is often diagnosed, not always amenable to therapy, and can lead to a complete loss of visual functions. In recent years, the method of osteopathic correction has become widespread as one of the effective methods of treatment and rehabilitation of patients with pathologies of various body systems. In the pathogenesis of glaucoma, it is customary to distinguish a dystrophic concept, which considers primary open-angle glaucoma as a result of dystrophic changes in the connective tissue, as well as in the endothelial lining of the trabeculae and Schlemm′s canal, especially destructive changes in mitochondria and the alteration of their functional activity. A vascular concept is also distinguished. According to this concept, the central link in the pathogenesis of glaucoma is circulatory disorder in the ciliary vessels, ocular artery, and major vessels of the head and neck, it can be assumed that osteopathic correction in the treatment of patients with open-angle glaucoma will be pathogenetically substantiated and will have a positive effect on intraocular pressure and trophicity of the optic nerve. The goal of research — to study the influence of in osteopathic correction on the nature of unoperated glaucoma (stage IIA) and to substantiate the possibility of using osteopathic correction in the complex treatment of patients with this pathology.Materials and methods. A prospective controlled randomized study was conducted at 52 city polyclinics, branch 3, Moscow, from January 2018 to January 2019. 40 patients (70 eyes) aged 50 to 75 years with primary open-angle glaucoma IIA stage were examined. At this stage of the disease, patients most often seek medical care and the issue of conservative management is primarily considered. All patients were divided into two groups of 20 people: the main group and the control group. The treatment in the main group included hypotensive drug therapy and osteopathic correction. Patients of the control group received only drug therapy. All patients underwent ophthalmic (visometry, tonometry, perimetry) and osteopathic examination twice: before the treatment and after 3 months.Results. For patients with primary open-angle IIA non-operated glaucoma, regional (most often regions of the head, neck, dura mater) and local (abdominal diaphragm, iliac bones, hip and knee joints) somatic dysfunctions were the most typical. In the main group a statistically significant decrease in the frequency and severity of dysfunctions at all levels was stated. Also, in patients receiving osteopathic correction, a significant decrease in the level of intraocular pressure and perimetric indices was noted. In patients of the control group, no reliable changes in these indicators were obtained.Conclusion. The results obtained indicate that osteopathic correction is clinically effective in the complex treatment of patients with primary open-angle II A glaucoma.

scholarly journals Effects of Ripasudil on Open-Angle Glaucoma after Circumferential Suture Trabeculotomy Ab Interno

2021 ◽  
Vol 10 (3) ◽  
pp. 401
Author(s):  
Tomoki Sato ◽  
Takahiro Kawaji
Keyword(s):  
Propensity Score Analysis ◽  
Open Angle Glaucoma ◽  
Outflow Tract ◽  
Control Group ◽  
Open Angle ◽  
Schlemm’S Canal ◽  
Schlemm's Canal ◽  
Score Analysis ◽  
The Mean ◽  
Ab Interno

We evaluated the effects of ripasudil on the distal aqueous outflow tract in patients with open-angle glaucoma (OAG) who underwent a 360° suture trabeculotomy ab interno followed by ripasudil treatment beginning 1 month postoperatively. We compared 27 of these patients, by using propensity score analysis, with 27 patients in a matched control group who had no ripasudil treatment. We assessed the changes in the mean intraocular pressure (IOP) and the relationship between the IOP changes and background factors. All eyes had a complete 360° Schlemm’s canal incision and phacoemulsification. The mean IOP at 1 and 3 months after ripasudil administration were significantly reduced by −1.7 ± 1.9 mmHg (p < 0.0001) and −1.3 ± 2.3 mmHg (p = 0.0081) in the ripasudil group, respectively, but IOP in the control group was not significantly reduced. The IOP reduction was significantly associated with the IOP before ripasudil treatment (p < 0.001). In conclusion, the use of ripasudil for patients with OAG after circumferential incision of the Schlemm’s canal produced significant IOP reductions. Ripasudil may affect the distal outflow tract, thereby leading to the IOP reduction.

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