Hypothesis-independent pathway analysis implicates GABA and Acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma

The review assesses physical exercises as an additional non-pharmacological mean of combating the progression of primary open-angle glaucoma. The ophthalmic hypotensive effect is determined by the type of exercise, its duration and intensity. Moderate aerobic activity is preferred. Among dynamic exercises, jogging has the greatest hypotensive effect. Upper body isometric resistance training provides a more lasting decrease in ophthalmotonus. The decrease in intraocular pressure (IOP) in patients with glaucoma is several times more pronounced in comparison with healthy people and occurs regardless of the nature of the local drug antihypertensive therapy. After the termination of classes IOP returns to the previous level on average within a month. An increase in ocular perfusion pressure associated with physical activity dictates the appropriateness of physical exercise for patients with pseudo-normal pressure glaucoma. The combination of hypotensive, vascular, neuroprotective effects of physical activity with a high level of physical fi tness does not exclude a decrease in the risk of development and progression of primary open-angle glaucoma. The development of indications for the use of physical activity by patients with advanced glaucoma, including those who have undergone hypotensive surgery, remains relevant. The type, intensity, dosage and mode of performing the recommended physical exercises require an individual choice.

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Normal pressure glaucoma. Open angle glaucoma

Laser Scanning: Update 1 ◽

10.1007/978-94-010-0322-3_8 ◽

2001 ◽

pp. 47-50

Author(s):

Jorge Vasco

Keyword(s):

Open Angle Glaucoma ◽

Normal Pressure ◽

Open Angle ◽

Normal Pressure Glaucoma

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The occurrence of optic disc haemorrhage in primary open‐angle glaucoma eyes with lower normal pressure and its relating factors

Acta Ophthalmologica ◽

10.1111/aos.14506 ◽

2020 ◽

Cited By ~ 1

Author(s):

Rei Sakata ◽

Takeshi Yoshitomi ◽

Makoto Araie ◽

Makoto Ishikawa ◽

Haruki Abe ◽

...

Keyword(s):

Optic Disc ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Normal Pressure ◽

Open Angle ◽

Disc Haemorrhage

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Impaired cardiovascular responses to baroreflex stimulation in open-angle and normal-pressure glaucoma

Clinical Science ◽

10.1042/cs1020623 ◽

2002 ◽

Vol 102 (6) ◽

pp. 623-630 ◽

Cited By ~ 24

Author(s):

Clive M. BROWN ◽

Matthias DÜTSCH ◽

Georg MICHELSON ◽

Bernhard NEUNDÖRFER ◽

Max J. HILZ

Keyword(s):

Blood Vessels ◽

Open Angle Glaucoma ◽

Cardiovascular Responses ◽

Normal Pressure ◽

Control Group ◽

Open Angle ◽

Baroreflex Control ◽

Rr Interval ◽

Normal Pressure Glaucoma ◽

Interval Response

Autonomic neuropathy may contribute to the pathophysiology of both open-angle and normal-pressure glaucoma. However, autonomic function has not been studied extensively in these diseases. We evaluated baroreflex control of the heart and blood vessels in open-angle and normal-pressure glaucoma. We studied 14 patients with open-angle glaucoma, 15 with normal-pressure glaucoma and 17 controls. Sinusoidal neck suction (0 to -30mmHg) was applied at 0.1Hz to assess the sympathetic modulation of the heart and blood vessels, and at 0.2Hz to assess the effect of parasympathetic stimulation on the heart. Baseline recordings showed no significant differences between the groups. The RR-interval response of the controls to neck suction at 0.1Hz (3.88±0.32 to 6.65±0.44lnms2) was significantly greater than that of the open-angle glaucoma patients (4.22±0.28 to 5.56±0.26lnms2) and the normal-pressure glaucoma patients (4.53±0.27 to 5.53±0.37lnms2) (P<0.05). The low-frequency power of diastolic blood pressure increased significantly in the controls (0.48±0.08 to 2.76±0.72mmHg2; P<0.01) during 0.1Hz neck suction, but did not change significantly in patients with either open-angle glaucoma or normal-pressure glaucoma. The RR-interval response in the control group (3.45±0.52lnms2) to neck suction at 0.2Hz was significantly greater than that of the normal-pressure glaucoma patients (1.84±0.32lnms2) and the open-angle glaucoma patients (1.58±0.35lnms2) (P<0.05). The decreased sympathetic and parasympathetic modulation during baroreceptor stimulation in patients with open-angle glaucoma and normal-pressure glaucoma suggests that autonomic dysfunction may contribute to the pathogenesis of both diseases.

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Genome-wide CNV investigation suggests a role for cadherin, Wnt, and p53 pathways in primary open-angle glaucoma

BMC Genomics ◽

10.1186/s12864-021-07846-1 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Valeria Lo Faro ◽

Jacoline B. ten Brink ◽

Harold Snieder ◽

Nomdo M. Jansonius ◽

Arthur A. Bergen

Keyword(s):

Association Analysis ◽

Pathway Analysis ◽

Molecular Mechanisms ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Copy Number Variations ◽

Open Angle ◽

Case Control Studies ◽

Functional Studies ◽

Genome Wide

Abstract Background To investigate whether copy number variations (CNVs) are implicated in molecular mechanisms underlying primary open-angle glaucoma (POAG), we used genotype data of POAG individuals and healthy controls from two case-control studies, AGS (n = 278) and GLGS-UGLI (n = 1292). PennCNV, QuantiSNP, and cnvPartition programs were used to detect CNV. Stringent quality controls at both sample and marker levels were applied. The identified CNVs were intersected in CNV region (CNVR). After, we performed burden analysis, CNV-genome-wide association analysis, gene set overrepresentation and pathway analysis. In addition, in human eye tissues we assessed the expression of the genes lying within significant CNVRs. Results We reported a statistically significant greater burden of CNVs in POAG cases compared to controls (p-value = 0,007). In common between the two cohorts, CNV-association analysis identified statistically significant CNVRs associated with POAG that span 11 genes (APC, BRCA2, COL3A1, HLA-DRB1, HLA-DRB5, HLA-DRB6, MFSD8, NIPBL, SCN1A, SDHB, and ZDHHC11). Functional annotation and pathway analysis suggested the involvement of cadherin, Wnt signalling, and p53 pathways. Conclusions Our data suggest that CNVs may have a role in the susceptibility of POAG and they can reveal more information on the mechanism behind this disease. Additional genetic and functional studies are warranted to ascertain the contribution of CNVs in POAG.

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