scholarly journals BMP7 reduces inflammation and oxidative stress in diabetic tubulopathy

2014 ◽  
Vol 128 (4) ◽  
pp. 269-280 ◽  
Author(s):  
Rui Xi Li ◽  
Wai Han Yiu ◽  
Hao Jia Wu ◽  
Dickson W. L. Wong ◽  
Loretta Y. Y. Chan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Responses ◽  
Advanced Glycation ◽  
Tubular Cells ◽  
Renal Tubular Cells ◽  
Glycation End Products ◽  
Renal Tubular ◽  
Diabetic Tubulopathy ◽  
Oxidative Stress Responses ◽  
And Oxidative Stress

BMP7 ameliorates diabetic tubulopathy by suppressing inflammatory and oxidative stress responses both in cultured renal tubular cells exposed to advanced glycation end-products and in diabetic db/db mice.

Ochratoxin A induces karyomegaly and cell cycle aberrations in renal tubular cells without relation to induction of oxidative stress responses in rats

2014 ◽  
Vol 224 (1) ◽  
pp. 64-72 ◽  
Author(s):  
Eriko Taniai ◽  
Atsunori Yafune ◽  
Masahiro Nakajima ◽  
Shim-Mo Hayashi ◽  
Fumiyuki Nakane ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Ochratoxin A ◽  
Stress Responses ◽  
Tubular Cells ◽  
Renal Tubular Cells ◽  
Renal Tubular ◽  
Oxidative Stress Responses

Cinnamaldehyde and Nitric Oxide Attenuate Advanced Glycation End Products-Induced the JAK/STAT Signaling in Human Renal Tubular Cells

2015 ◽  
Vol 116 (6) ◽  
pp. 1028-1038 ◽  
Author(s):  
Jau-Shyang Huang ◽  
Ying-Ho Lee ◽  
Lea-Yea Chuang ◽  
Jinn-Yuh Guh ◽  
Jean-Yu Hwang
Keyword(s):  
Nitric Oxide ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Tubular Cells ◽  
Renal Tubular Cells ◽  
Glycation End Products ◽  
End Products ◽  
Stat Signaling ◽  
Renal Tubular

Advanced glycation end products-mediated hypertrophy is negatively regulated by tetrahydrobiopterin in renal tubular cells

2012 ◽  
Vol 355 (1) ◽  
pp. 71-77 ◽  
Author(s):  
Yi-Chen Liao ◽  
Ying-Ho Lee ◽  
Lea-Yea Chuang ◽  
Jinn-Yuh Guh ◽  
Ming-Der Shi ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Tubular Cells ◽  
Renal Tubular Cells ◽  
Glycation End Products ◽  
End Products ◽  
Renal Tubular

scholarly journals Effects of Nitric Oxide and Antioxidants on Advanced Glycation End Products-Induced Hypertrophic Growth in Human Renal Tubular Cells

2009 ◽  
Vol 111 (1) ◽  
pp. 109-119 ◽  
Author(s):  
Jau-Shyang Huang ◽  
Lea-Yea Chuang ◽  
Jinn-Yuh Guh ◽  
Yann-Jia Huang
Keyword(s):  
Nitric Oxide ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Hypertrophic Growth ◽  
Tubular Cells ◽  
Renal Tubular Cells ◽  
Glycation End Products ◽  
End Products ◽  
Renal Tubular

scholarly journals Losartan Ameliorates Calcium Oxalate-Induced Elevation of Stone-Related Proteins in Renal Tubular Cells by Inhibiting NADPH Oxidase and Oxidative Stress

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Baolong Qin ◽  
Qing Wang ◽  
Yuchao Lu ◽  
Cong Li ◽  
Henglong Hu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nadph Oxidase ◽  
Calcium Oxalate ◽  
Stone Formation ◽  
Ang Ii ◽  
Tubular Cells ◽  
Renal Tubular Cells ◽  
Renal Tubular ◽  
Related Proteins ◽  
And Oxidative Stress

Calcium oxalate (CaOx) is the most common type of urinary stone. Increase of ROS and NADPH oxidase gives rise to inflammation and injury of renal tubular cells, which promotes CaOx stone formation. Recent studies have revealed that the renin-angiotensin system might play a role in kidney crystallization and ROS production. Here, we investigated the involvement of Ang II/AT1R and losartan in CaOx stone formation. NRK-52E cells were incubated with CaOx crystals, and glyoxylic acid-induced hyperoxaluric rats were treated with losartan. Oxidative stress statuses were evaluated by detection of ROS, oxidative products (8-OHdG and MDA), and antioxidant enzymes (SOD and CAT). Expression of NADPH oxidase subunits (Nox2 and Nox4), NF-κB pathway subunits (p50 and p65), and stone-related proteins such as OPN, CD44, and MCP-1 was determined by Western blotting. The results revealed upregulation of Ang II/AT1R by CaOx treatment. CaOx-induced ROS and stone-related protein upregulation were mediated by the Ang II/AT1R signaling pathway. Losartan ameliorated renal tubular cell expression of stone-related proteins and renal crystallization by inhibiting NADPH oxidase and oxidative stress. We conclude that losartan might be a promising preventive and therapeutic candidate for hyperoxaluria nephrolithiasis.

Repressive effect of Rhus coriaria L. fruit extracts on microglial cells-mediated inflammatory and oxidative stress responses

2021 ◽  
Vol 269 ◽  
pp. 113748
Author(s):  
Mohamad Khalil ◽  
Ali Bazzi ◽  
Dana Zeineddine ◽  
Wissam Jomaa ◽  
Ahmad Daher ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Responses ◽  
Microglial Cells ◽  
Fruit Extracts ◽  
Repressive Effect ◽  
Rhus Coriaria ◽  
Oxidative Stress Responses ◽  
And Oxidative Stress

Hyperbaric oxygen treatment reverses radiation induced pro-fibrotic and oxidative stress responses in a rat model

2017 ◽  
Vol 103 ◽  
pp. 248-255 ◽  
Author(s):  
N. Oscarsson ◽  
L. Ny ◽  
J. Mölne ◽  
F. Lind ◽  
S.-E. Ricksten ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hyperbaric Oxygen ◽  
Rat Model ◽  
Stress Responses ◽  
Hyperbaric Oxygen Treatment ◽  
Oxygen Treatment ◽  
Radiation Induced ◽  
Oxidative Stress Responses ◽  
And Oxidative Stress
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