Voxel-Based Lesion Symptom Mapping of Coarse Coding and Suppression Deficits in Patients With Right Hemisphere Damage

ABSTRACTWe have compared the verbal comprehension abilities of 34 right hemisphere damaged patients to 16 hospitalized control subjects of comparable age and educational attainment. The right hemisphere damaged patients performed as well as the control subjects on a vocabulary test, but were impaired in their ability to interpret proverbs and comprehend logico-grammatical sentences. Impairment on the proverbs test was the result of a decrease in the number of abstract interpretations, whereas impairment on the logico-grammatical sentence comprehension test was related to difficultes in grasping spatial and passive relationships. These comprehension impairments tended to correlate with visuospatial deficits and hemianopia, but not with the degree of hemiparesis or the presence of sensory extinction. Patients with anterior right hemisphere damage performed better on the logico-grammatical sentence conprehension test than patients with posterior damage. A variety of factors probably contribute to these verbal deficits including impaired intellect, inattention, an inability to grasp spatial relationships, and difficulties in manipulating the inner schemata of language.

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Are visual working memory and episodic memory distinct processes? Insight from stroke patients by lesion-symptom mapping

Brain Structure and Function ◽

10.1007/s00429-021-02281-0 ◽

2021 ◽

Author(s):

Selma Lugtmeijer ◽

◽

Linda Geerligs ◽

Frank Erik de Leeuw ◽

Edward H. F. de Haan ◽

...

Keyword(s):

Working Memory ◽

Episodic Memory ◽

Visual Working Memory ◽

Visual Memory ◽

Right Hemisphere ◽

Memory Task ◽

Stroke Patients ◽

Lesion Symptom Mapping ◽

Criterion Setting ◽

The Right

AbstractWorking memory and episodic memory are two different processes, although the nature of their interrelationship is debated. As these processes are predominantly studied in isolation, it is unclear whether they crucially rely on different neural substrates. To obtain more insight in this, 81 adults with sub-acute ischemic stroke and 29 elderly controls were assessed on a visual working memory task, followed by a surprise subsequent memory test for the same stimuli. Multivariate, atlas- and track-based lesion-symptom mapping (LSM) analyses were performed to identify anatomical correlates of visual memory. Behavioral results gave moderate evidence for independence between discriminability in working memory and subsequent memory, and strong evidence for a correlation in response bias on the two tasks in stroke patients. LSM analyses suggested there might be independent regions associated with working memory and episodic memory. Lesions in the right arcuate fasciculus were more strongly associated with discriminability in working memory than in subsequent memory, while lesions in the frontal operculum in the right hemisphere were more strongly associated with criterion setting in subsequent memory. These findings support the view that some processes involved in working memory and episodic memory rely on separate mechanisms, while acknowledging that there might also be shared processes.

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Unwanted reflex-like saccades in visual extinction patients

Behavioral and Brain Sciences ◽

10.1017/s0140525x99312152 ◽

1999 ◽

Vol 22 (4) ◽

pp. 683-683 ◽

Cited By ~ 1

Author(s):

Alessandra Fanini ◽

Carlo Alberto Marzi

Keyword(s):

Reaction Time ◽

Right Hemisphere ◽

Visual Stimuli ◽

Reaction Time Task ◽

Time Task ◽

Right Hemisphere Damage ◽

Visual Extinction ◽

Manual Reaction Time

We studied patients with left visual extinction following right hemisphere damage in a simple manual reaction time task using brief visual stimuli. With unilateral lateralized stimuli the patients showed a high proportion of unwanted, reflex-like saccades to either side of stimulation. In contrast, with bilateral stimuli there was an overall decrease in the proportion of unwanted saccades, and the vast majority of them were directed toward the ipsilesional side. The implications of these results for the Findlay & Walker model are discussed.

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Disturbance of rhythm sense following right hemisphere damage

Neuropsychologia ◽

10.1016/0028-3932(90)90047-r ◽

1990 ◽

Vol 28 (12) ◽

pp. 1317-1323 ◽

Cited By ~ 45

Author(s):

Wolfgang Fries ◽

Andrew A. Swihart

Keyword(s):

Right Hemisphere ◽

Right Hemisphere Damage

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Interaction between spatial neglect and attention deficit in patients with right hemisphere damage

Cortex ◽

10.1016/j.cortex.2021.03.036 ◽

2021 ◽

Author(s):

Yusaku Takamura ◽

Shintaro Fujii ◽

Satoko Ohmatsu ◽

Koki Ikuno ◽

Kohei Tanaka ◽

...

Keyword(s):

Attention Deficit ◽

Right Hemisphere ◽

Spatial Neglect ◽

Right Hemisphere Damage

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Right hemisphere damage: Communication processing in adults evaluated by the Brazilian Protocole MEC - Bateria MAC

Dementia & Neuropsychologia ◽

10.1590/s1980-57642008dn10300008 ◽

2007 ◽

Vol 1 (3) ◽

pp. 266-275 ◽

Cited By ~ 4

Author(s):

Rochele Paz Fonseca ◽

Jandyra Maria Guimarães Fachel ◽

Márcia Lorena Fagundes Chaves ◽

Francéia Veiga Liedtke ◽

Maria Alice de Mattos Pimenta Parente

Keyword(s):

Right Hemisphere ◽

Damage Effect ◽

Control Group ◽

Clinical Group ◽

Conversational Discourse ◽

Lexical Semantic ◽

Right Hemisphere Damage ◽

Right Brain ◽

Communication Processes ◽

Brazilian Version

Abstract Right-brain-damaged individuals may present discursive, pragmatic, lexical-semantic and/or prosodic disorders. Objective: To verify the effect of right hemisphere damage on communication processing evaluated by the Brazilian version of the Protocole Montréal d'Évaluation de la Communication (Montreal Communication Evaluation Battery) - Bateria Montreal de Avaliação da Comunicação, Bateria MAC, in Portuguese. Methods: A clinical group of 29 right-brain-damaged participants and a control group of 58 non-brain-damaged adults formed the sample. A questionnaire on sociocultural and health aspects, together with the Brazilian MAC Battery was administered. Results: Significant differences between the clinical and control groups were observed in the following MAC Battery tasks: conversational discourse, unconstrained, semantic and orthographic verbal fluency, linguistic prosody repetition, emotional prosody comprehension, repetition and production. Moreover, the clinical group was less homogeneous than the control group. Conclusions: A right-brain-damage effect was identified directly, on three communication processes: discursive, lexical-semantic and prosodic processes, and indirectly, on pragmatic process.

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Sensory deficits in ipsilesional upper-extremity in chronic stroke patients

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20150128 ◽

2015 ◽

Vol 73 (10) ◽

pp. 834-839 ◽

Cited By ~ 9

Author(s):

Núbia Maria Freire Vieira Lima ◽

Karina Cândido Menegatti ◽

Érica Yu ◽

Natália Yumi Sacomoto ◽

Thais Botossi Scalha ◽

...

Keyword(s):

Right Hemisphere ◽

Thermal Sensation ◽

Chronic Stroke ◽

Sensory Loss ◽

Stroke Patients ◽

Sensory Assessment ◽

Sensory Deficits ◽

Left Handed ◽

Right Hemisphere Damage ◽

The Right

Objective To investigate somatosensory deficits in the ipsilesional wrist and hand in chronic stroke patients and correlate these deficits with contralesional sensorimotor dysfunctions, functional testing, laterality and handedness.Methods Fifty subjects (twenty-two healthy volunteers and twenty-eight stroke patients) underwent evaluation with Semmes-Weinstein monofilaments, the sensory and motor Fugl-Meyer Assessment, the Nottingham Sensory Assessment in both wrists and hands and functional tests.Results Twenty-five patients had sensory changes in the wrist and hand contralateral to the stroke, and eighteen patients (64%) had sensory deficits in the ipsilesional wrist and hand. The most significant ipsilesional sensory loss was observed in the left-handed patients. We found that the patients with brain damage in the right hemisphere had better scores for ipsilesional tactile sensation.Conclusions A reduction in ipsilesional conscious proprioception, tactile or thermal sensation was found in stroke subjects. Right hemisphere damage and right-handed subjects had better scores in ipsilesional tactile sensation.

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Understanding Others Requires Right Temporoparietal and Inferior Frontal Regions

10.1101/2021.03.31.437941 ◽

2021 ◽

Author(s):

Tatiana Schnur ◽

Junhua Ding ◽

Margaret Blake

Keyword(s):

Theory Of Mind ◽

Brain Damage ◽

Right Hemisphere ◽

Knowledge And Beliefs ◽

Human Ability ◽

Lesion Symptom Mapping ◽

Right Hemisphere Brain Damage ◽

Acute Patients ◽

Long Term Studies

The human ability to infer other people's knowledge and beliefs, known as 'theory of mind', is an essential component of social interactions. Theory of mind tasks activate frontal and temporoparietal regions of cortex in fMRI studies. However, it is unknown whether these regions are critical. We examined this question using multivariate voxel-based lesion symptom mapping in 22 patients with acute right hemisphere brain damage. Studies of acute patients eliminate questions of recovery and reorganization that plague long-term studies of lesioned patients. Damage to temporoparietal and inferior frontal regions impaired thinking about others' perspectives. This impairment held even after adjustment for overall extent of brain damage and language comprehension, memory, comprehension, and attention abilities. These results provide evidence that right temporoparietal and inferior frontal regions are necessary for the human ability to reason about the knowledge and beliefs of others.

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