Dysphagia Symptoms and Treatment in Huntington's Disease: Review

2012 ◽  
Vol 21 (4) ◽  
pp. 126-134 ◽  
Author(s):  
Celia Stewart
Keyword(s):  
Systematic Review ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Aspiration Pneumonia ◽  
Causes Of Death ◽  
Original Research ◽  
Inclusion Criteria ◽  
Review Articles ◽  
Common Causes ◽  
Random Control

The most common causes of death in individuals with Huntington's disease (HD) are aspiration pneumonia and choking on food. The goal of this systematic review is to describe the scope of dysphagia symptoms and current treatments for individuals with HD. This review includes studies that met the following criteria: original research, presentation of swallowing symptoms and/or treatment, and availability in print and in English. Nine research studies and two review articles met the inclusion criteria. No random control or nonrandom studies were found. Dysphagia symptoms were reported in all phases of the swallow.

scholarly journals The global prevalence of Huntington's disease: a systematic review and discussion

2016 ◽  
Vol 6 (4) ◽  
pp. 331-343 ◽  
Author(s):  
Sheharyar Sajjad Baig ◽  
Mark Strong ◽  
Oliver WJ Quarrell
Keyword(s):  
Systematic Review ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Global Prevalence

scholarly journals Understanding the ”Extra-Corporeal Membrane Oxygenation Gap" in Veno-Arterial Configuration for Adult Patients: Timing and Causes of Death. Defining the Veno-Arterial Extracorporeal Membrane Oxygenation Gap

2020 ◽  
Author(s):  
Maged Makhoul ◽  
Samuel Heuts ◽  
Abdulrahman Mansouri ◽  
Fabio Silvio Taccone ◽  
Amir Obeid ◽  
...  
Keyword(s):  
Systematic Review ◽  
Extracorporeal Membrane Oxygenation ◽  
Hospital Mortality ◽  
Causes Of Death ◽  
Neurological Complications ◽  
Multiple Organ ◽  
Adult Patients ◽  
Membrane Oxygenation ◽  
Common Causes ◽  
Overall Mortality

Abstract Background Timing and causes of hospital mortality in adult patients undergoing veno-arterial extracorporeal membrane oxygenation (V-A ECMO) have been poorly described. Aim of the current review was to investigate the timing and causes of death of adult patients treated with V-A ECMO, and subsequently define the “V-A ECMO gap”, which represents the patients who are successfully weaned of ECMO but eventually die during hospital stay.Methods A systematic search was performed using electronic MEDLINE and EMBASE databases through PubMed. Studies reporting on adult V-A ECMO patients from January 1993 to October 2018 were screened. Timing, rates and causes of in-hospital mortality were analyzed.Results Sixty studies with 9,181 patients were included in this systematic review. Overall mortality was 37.6% during V-A ECMO support (reported by 60 studies) and 28.9% (57 studies) after weaning. Finally, 32.6% were discharged from hospital (60 studies). Most common causes of death on ECMO were multiple organ failure (MOF, 49.8%), followed by cardiac failure (20.6%) and neurological causes (15.7%). Most common causes of death after weaning were MOF (55.3%), followed by neurological complications (12.6%), persistent heart failure (10.7%) and pulmonary infections (6.8%).Conclusions More than one-third of adult V-A ECMO patients die during ECMO therapy. Additionally, almost one half of successfully weaned patients still decease during hospital stay, defining the “V-A ECMO gap”. Underreporting and lack of uniformity in reporting of important parameters remains problematic in ECMO research. Future studies should uniformly define timing and causes of death in V-A ECMO patients to better understand the effectiveness and complications of this therapy. Systematic review registration PROSPERO 2019 number CRD42019130815

scholarly journals Sarcopenic is associated with hypertension in older adults: a systematic review and meta-analysis

2020 ◽  
Author(s):  
Tingting Bai ◽  
Fang Fang ◽  
Feika Li ◽  
Yan Ren ◽  
Jiaan Hu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Confidence Interval ◽  
Handgrip Strength ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Original Research ◽  
Inclusion Criteria ◽  
Asian Group ◽  
Research Studies

Abstract BackgroundBoth sarcopenia and handgrip strength have been observed association with hypertension. However, the results in different studies were inconsistent. In the current study, we conducted a systematic review and meta-analysis to reveal the association between sarcopenia, handgrip strength, and hypertension in older adults.MethodsPubMed, MEDLINE, Cochrane Library, and EMBASE databases were searched from inception to 15 November, 2019for original research studies. The studies that addressed the association between sarcopenia, handgrip strength, and hypertension were included and summarized.Results19 studies met the inclusion criteria and a total of 21301 were included in the meta-analysis. Eight eligible studiesreported the odd ratios (ORs) of hypertension and the ORs ranged from 0.41 to 4.38. When pooled the ORs together, the summarized ORs was 1.29 [95% confidence interval (CI) =1.00-1.67]. The summarized ORs for the Asian group 1.50 (95% CI=1.35-1.67) was significantly higher than that of Caucasian group 1.08 (95% CI=0.39-2.97). Eleven studies provided the data on association between handgrip strength and hypertension. The overall ORs and 95% CI was 0.99 (95% CI=0.80-1.23), showing no association.ConclusionSarcopenia was associated with hypertension but no correlation was found between handgrip strength and hypertension in older adults.

scholarly journals Physical Therapy and Exercise Interventions in Huntington’s Disease: A Mixed Methods Systematic Review

2017 ◽  
Vol 6 (3) ◽  
pp. 217-235 ◽  
Author(s):  
Nora E. Fritz ◽  
Ashwini K. Rao ◽  
Deb Kegelmeyer ◽  
Anne Kloos ◽  
Monica Busse ◽  
...  
Keyword(s):  
Systematic Review ◽  
Mixed Methods ◽  
Physical Therapy ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Exercise Interventions

The Efficacy and Safety of Pridopidine on Treatment of Huntington's Disease Patients: A Systematic Review and Meta‐Analysis

2021 ◽  
Author(s):  
Moamen Mostafa Asla ◽  
Asmaa Ahmed Nawar ◽  
Alaa Abdelsalam ◽  
Esraa Elsayed ◽  
Marwa Abdelazim Rizk ◽  
...  
Keyword(s):  
Systematic Review ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Meta Analysis ◽  
Efficacy And Safety
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