Surface immunoglobulin on B lymphocytes as a potential target for specific peptide ligands in chronic lymphocytic leukaemia

2002 ◽  
Vol 116 (3) ◽  
pp. 549-554 ◽  
Author(s):  
L. Buhl ◽  
P. B. Szecsi ◽  
G. G. Gisselø ◽  
C. Schafer-Nielsen
Keyword(s):  
Chronic Lymphocytic Leukaemia ◽  
B Lymphocytes ◽  
Lymphocytic Leukaemia ◽  
Peptide Ligands ◽  
Potential Target ◽  
Surface Immunoglobulin ◽  
Specific Peptide

Chromosome abnormalities of leukaemic B lymphocytes in chronic lymphocytic leukaemia

Nature ◽  
1980 ◽  
Vol 283 (5742) ◽  
pp. 76-78 ◽  
Author(s):  
John N. Hurley ◽  
Shu Man Fu ◽  
Henry G. Kunkel ◽  
R. S. K. Chaganti ◽  
James German
Keyword(s):  
Chronic Lymphocytic Leukaemia ◽  
B Lymphocytes ◽  
Lymphocytic Leukaemia ◽  
Chromosome Abnormalities

Chronic lymphocytic leukaemia

2010 ◽  
pp. 4240-4247
Author(s):  
Clive S. Zent ◽  
Aaron Polliack
Keyword(s):  
North America ◽  
Chronic Lymphocytic Leukaemia ◽  
B Lymphocyte ◽  
Lymphocytic Leukaemia ◽  
Immunoglobulin Gene ◽  
Cell Of Origin ◽  
Small Lymphocytic Lymphoma ◽  
Lymphoid Neoplasm ◽  
Surface Immunoglobulin

Chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL) is the most prevalent lymphoid neoplasm in Europe and North America. The ‘cell of origin’ is a mature B lymphocyte that has a rearranged immunoglobulin gene. CLL cells express modest amounts of surface immunoglobulin, and are characterized by defective apoptosis. The cause of CLL is unknown....

scholarly journals The Occurrence of Richter’s Syndrome during Treatment with Obinutuzumab and Chlorambucil

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Teng Fong Ng ◽  
Benedict Carnley ◽  
Celia Green ◽  
Dominic Spagnolo ◽  
Michael F. Leahy
Keyword(s):  
Chronic Lymphocytic Leukaemia ◽  
B Lymphocytes ◽  
Lymphocytic Leukaemia ◽  
Aggressive Lymphoma ◽  
Treatment Regimens ◽  
Slow Growing ◽  
Richter’S Syndrome

Chronic lymphocytic leukaemia is a slow-growing leukaemia of developing B-lymphocytes, which may transform to an aggressive lymphoma known as Richter’s syndrome. While Richter’s syndrome can present in untreated or relapsed-refractory cases, it may occur upon the commencement of less intensity treatment regimens. We present a case of Richter’s syndrome following treatment with chlorambucil and obinutuzumab and review of available literature on the topic.

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